XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)

Detalhes bibliográficos
Autor(a) principal: Falagan-Lotsch, Priscila
Data de Publicação: 2009
Outros Autores: Rodrigues, Marina S., Esteves, Viviane, Vieira, Roberto, Amendola, Luis C., Pagnoncelli, Dante, Paixão, Júlio C., Gallo, Claudia V. De Moura
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10042
Resumo: Universidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil.
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spelling Falagan-Lotsch, PriscilaRodrigues, Marina S.Esteves, VivianeVieira, RobertoAmendola, Luis C.Pagnoncelli, DantePaixão, Júlio C.Gallo, Claudia V. De Moura2015-04-17T13:23:30Z2015-04-17T13:23:30Z2009FALAGAN-LOTSCH, Priscila. et al. XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil). Genet. mol. biol., Ribeirao Preto, v. 32, n. 2, p. 255-259 , 20091415-4757https://www.arca.fiocruz.br/handle/icict/10042porSociedade Brasileira de GenéticaXRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Biologia Molecular. Rio de Janeiro, RJ, Brasil.The X-ray repair cross-complementing Group1 (XRCC1)gene has been defined as essential in the base excision re-pair (BER) and single-strand break repair processes. This gene is highly polymorphic, and the most extensively stud-ied genetic changes are in exon 6 (Arg194Trp) and in exon 10 (Arg399Gln). These changes, in conserved protein sites, may alter the base excision repair capacity, increasing the susceptibility to adverse health conditions, including cancer. In the present study, we estimated the frequencies of theXRCC1gene polymorphisms Arg194Trp and Arg399Gln in healthy individuals and also in women at risk of breast cancer due to family history from Rio de Janeiro. The common genotypes in both positions (194 and 399) were the most frequent in this Brazilian sample. Although the 194Trp variant was overrepresented in women reporting familial cases of breast cancer, no statistically signifi-cant differences concerning genotype distribution or intragenic interactions were found between this group and the controls. Thus, in the population analyzed by us, variants Arg194Trp and Arg399Gln did not appear to have any im-pact on breast cancer susceptibility.XRCC1Gene PolymorphismsBreast Cancer SusceptibilityBrazilian PopulationNeoplasias da MamaPopulaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10042/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALXRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janei.pdfXRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janei.pdfapplication/pdf67585https://www.arca.fiocruz.br/bitstream/icict/10042/2/XRCC1%20gene%20polymorphisms%20in%20a%20population%20sample%20and%20in%20women%20with%20a%20family%20history%20of%20breast%20cancer%20from%20Rio%20de%20Janei.pdfecfb467c511dc0b2e098df0edd1f8900MD52TEXTXRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janei.pdf.txtXRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janei.pdf.txtExtracted texttext/plain24045https://www.arca.fiocruz.br/bitstream/icict/10042/3/XRCC1%20gene%20polymorphisms%20in%20a%20population%20sample%20and%20in%20women%20with%20a%20family%20history%20of%20breast%20cancer%20from%20Rio%20de%20Janei.pdf.txt34d0acbb8b9a92edc554c61eb737f3f7MD53icict/100422018-04-04 08:26:31.373oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-04T11:26:31Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
title XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
spellingShingle XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
Falagan-Lotsch, Priscila
XRCC1Gene Polymorphisms
Breast Cancer Susceptibility
Brazilian Population
Neoplasias da Mama
População
title_short XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
title_full XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
title_fullStr XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
title_full_unstemmed XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
title_sort XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
author Falagan-Lotsch, Priscila
author_facet Falagan-Lotsch, Priscila
Rodrigues, Marina S.
Esteves, Viviane
Vieira, Roberto
Amendola, Luis C.
Pagnoncelli, Dante
Paixão, Júlio C.
Gallo, Claudia V. De Moura
author_role author
author2 Rodrigues, Marina S.
Esteves, Viviane
Vieira, Roberto
Amendola, Luis C.
Pagnoncelli, Dante
Paixão, Júlio C.
Gallo, Claudia V. De Moura
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Falagan-Lotsch, Priscila
Rodrigues, Marina S.
Esteves, Viviane
Vieira, Roberto
Amendola, Luis C.
Pagnoncelli, Dante
Paixão, Júlio C.
Gallo, Claudia V. De Moura
dc.subject.en.pt_BR.fl_str_mv XRCC1Gene Polymorphisms
Breast Cancer Susceptibility
Brazilian Population
topic XRCC1Gene Polymorphisms
Breast Cancer Susceptibility
Brazilian Population
Neoplasias da Mama
População
dc.subject.decs.pt_BR.fl_str_mv Neoplasias da Mama
População
description Universidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2015-04-17T13:23:30Z
dc.date.available.fl_str_mv 2015-04-17T13:23:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FALAGAN-LOTSCH, Priscila. et al. XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil). Genet. mol. biol., Ribeirao Preto, v. 32, n. 2, p. 255-259 , 2009
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10042
dc.identifier.issn.none.fl_str_mv 1415-4757
identifier_str_mv FALAGAN-LOTSCH, Priscila. et al. XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil). Genet. mol. biol., Ribeirao Preto, v. 32, n. 2, p. 255-259 , 2009
1415-4757
url https://www.arca.fiocruz.br/handle/icict/10042
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/10042/2/XRCC1%20gene%20polymorphisms%20in%20a%20population%20sample%20and%20in%20women%20with%20a%20family%20history%20of%20breast%20cancer%20from%20Rio%20de%20Janei.pdf
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