XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)
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Publication Date: | 2009 |
Other Authors: | , , , , , , |
Format: | Article |
Language: | por |
Source: | Repositório Institucional da FIOCRUZ (ARCA) |
Download full: | https://www.arca.fiocruz.br/handle/icict/10042 |
Summary: | Universidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil. |
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Falagan-Lotsch, PriscilaRodrigues, Marina S.Esteves, VivianeVieira, RobertoAmendola, Luis C.Pagnoncelli, DantePaixão, Júlio C.Gallo, Claudia V. De Moura2015-04-17T13:23:30Z2015-04-17T13:23:30Z2009FALAGAN-LOTSCH, Priscila. et al. XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil). Genet. mol. biol., Ribeirao Preto, v. 32, n. 2, p. 255-259 , 20091415-4757https://www.arca.fiocruz.br/handle/icict/10042porSociedade Brasileira de GenéticaXRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Biologia Molecular. Rio de Janeiro, RJ, Brasil.The X-ray repair cross-complementing Group1 (XRCC1)gene has been defined as essential in the base excision re-pair (BER) and single-strand break repair processes. This gene is highly polymorphic, and the most extensively stud-ied genetic changes are in exon 6 (Arg194Trp) and in exon 10 (Arg399Gln). These changes, in conserved protein sites, may alter the base excision repair capacity, increasing the susceptibility to adverse health conditions, including cancer. In the present study, we estimated the frequencies of theXRCC1gene polymorphisms Arg194Trp and Arg399Gln in healthy individuals and also in women at risk of breast cancer due to family history from Rio de Janeiro. The common genotypes in both positions (194 and 399) were the most frequent in this Brazilian sample. Although the 194Trp variant was overrepresented in women reporting familial cases of breast cancer, no statistically signifi-cant differences concerning genotype distribution or intragenic interactions were found between this group and the controls. Thus, in the population analyzed by us, variants Arg194Trp and Arg399Gln did not appear to have any im-pact on breast cancer susceptibility.XRCC1Gene PolymorphismsBreast Cancer SusceptibilityBrazilian PopulationNeoplasias da MamaPopulaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10042/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALXRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janei.pdfXRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janei.pdfapplication/pdf67585https://www.arca.fiocruz.br/bitstream/icict/10042/2/XRCC1%20gene%20polymorphisms%20in%20a%20population%20sample%20and%20in%20women%20with%20a%20family%20history%20of%20breast%20cancer%20from%20Rio%20de%20Janei.pdfecfb467c511dc0b2e098df0edd1f8900MD52TEXTXRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janei.pdf.txtXRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janei.pdf.txtExtracted texttext/plain24045https://www.arca.fiocruz.br/bitstream/icict/10042/3/XRCC1%20gene%20polymorphisms%20in%20a%20population%20sample%20and%20in%20women%20with%20a%20family%20history%20of%20breast%20cancer%20from%20Rio%20de%20Janei.pdf.txt34d0acbb8b9a92edc554c61eb737f3f7MD53icict/100422018-04-04 08:26:31.373oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-04T11:26:31Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv |
XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) |
title |
XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) |
spellingShingle |
XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) Falagan-Lotsch, Priscila XRCC1Gene Polymorphisms Breast Cancer Susceptibility Brazilian Population Neoplasias da Mama População |
title_short |
XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) |
title_full |
XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) |
title_fullStr |
XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) |
title_full_unstemmed |
XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) |
title_sort |
XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) |
author |
Falagan-Lotsch, Priscila |
author_facet |
Falagan-Lotsch, Priscila Rodrigues, Marina S. Esteves, Viviane Vieira, Roberto Amendola, Luis C. Pagnoncelli, Dante Paixão, Júlio C. Gallo, Claudia V. De Moura |
author_role |
author |
author2 |
Rodrigues, Marina S. Esteves, Viviane Vieira, Roberto Amendola, Luis C. Pagnoncelli, Dante Paixão, Júlio C. Gallo, Claudia V. De Moura |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Falagan-Lotsch, Priscila Rodrigues, Marina S. Esteves, Viviane Vieira, Roberto Amendola, Luis C. Pagnoncelli, Dante Paixão, Júlio C. Gallo, Claudia V. De Moura |
dc.subject.en.pt_BR.fl_str_mv |
XRCC1Gene Polymorphisms Breast Cancer Susceptibility Brazilian Population |
topic |
XRCC1Gene Polymorphisms Breast Cancer Susceptibility Brazilian Population Neoplasias da Mama População |
dc.subject.decs.pt_BR.fl_str_mv |
Neoplasias da Mama População |
description |
Universidade Estadual do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2015-04-17T13:23:30Z |
dc.date.available.fl_str_mv |
2015-04-17T13:23:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FALAGAN-LOTSCH, Priscila. et al. XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil). Genet. mol. biol., Ribeirao Preto, v. 32, n. 2, p. 255-259 , 2009 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/10042 |
dc.identifier.issn.none.fl_str_mv |
1415-4757 |
identifier_str_mv |
FALAGAN-LOTSCH, Priscila. et al. XRCC1gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil). Genet. mol. biol., Ribeirao Preto, v. 32, n. 2, p. 255-259 , 2009 1415-4757 |
url |
https://www.arca.fiocruz.br/handle/icict/10042 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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