Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55540 |
Resumo: | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Ginecologia e Obstetrícia. Ribeirão Preto, SP, Brasil. |
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Duarte, GeraldoMuresan, PetronellaWard, ShawnLaimon, LaurenPelton, Stephen I.Canniff, JenniferGolner, Amanda GolnerBone, FredericNewton, LassalleteFenton, TerenceCoutinho, Conrado M.João, Esau C.Santos, Breno R.Pilotto, Jose Henrique da SilvaOliveira, Ricardo H.Pinto, Jorge A.Machado, Elizabeth S.Kreitchman, RegisChakhtoura, NahidaMussi-Pinhata, Marisa M.Weinberg, Adrianafor NICHD P1091 Study Team2022-11-08T19:13:50Z2022-11-08T19:13:50Z2021DUARTE, Geraldo et al. Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV. The Journal of Infectious Diseases, v. 225, p. 1021–1031, 2022.1413-8670https://www.arca.fiocruz.br/handle/icict/5554010.1093/infdis/jiab567engOxford University PressArteInfecção pelo HIVPCVPPVGravidezARTHIV infectionPCVPPVPregnancyImmunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIVinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Ginecologia e Obstetrícia. Ribeirão Preto, SP, Brasil.Frontier Science Foundation. Brookline, Massachusetts, USA.Frontier Science Foundation. Brookline, Massachusetts, USA.Westat, Rockville. Maryland, USA.Boston University School of Medicine. Boston, Massachusetts, USA.Department of Pediatrics, University of Colorado Anschutz Medical Campus. Aurora, Colorado, USA.Frontier Science Foundation. Buffalo, New York, USA.Frontier Science Foundation. Buffalo, New York, USA.Westat, Rockville. Maryland, USA.Frontier Science Foundation. Brookline, Massachusetts, USA.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Ginecologia e Obstetrícia. Ribeirão Preto, SP, Brasil.Hospital dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital Nossa Senhora da Conceicao. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.Instituto de Puericultura e Pediatra Matagão Gesteira. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Escola de Medicina. Belo Horizonte, MG, Brasil.Instituto de Puericultura e Pediatra Matagão Gesteira. Rio de Janeiro, RJ, Brasil.Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre, RS, Brasil.Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, Maryland, USA.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Pediatria. Ribeirão Preto, SP, Brasil.Department of Pediatrics, University of Colorado Anschutz Medical Campus. Aurora, Colorado, USA.for NICHD P1091 Study TeamBackground. Pneumococcal vaccination is recommended in people with HIV, prioritizing PCV. We compared the immunogenicity of PCV-10 and PPV-23 administered antepartum or postpartum. Methods. This double-blind study randomized 346 pregnant women with HIV on antiretrovirals to PCV-10, PPV-23, or placebo at 14–34 weeks gestational age. Women who received placebo antepartum were randomized at 24 weeks postpartum to PCV-10 or PPV-23. Antibodies against 7 serotypes common to both vaccines and 1 serotype only in PPV-23 were measured by ELISA/chemiluminescence; B- and T-cell responses to serotype 1 by FLUOROSPOT; and plasma cytokines/chemokines by chemiluminescence. Results. Antibody responses were higher after postpartum versus antepartum vaccination. PCV-10 generated lower antibody levels than PPV-23 against 4 and higher against 1 of 7 common serotypes. Additional factors associated with high postvaccination antibody concentrations were high prevaccination antibody concentrations and CD4+ cells; low CD8+ cells and plasma HIV RNA; and several plasma cytokines/chemokines. Serotype 1 B- and T-cell memory did not increase after vaccination. Conclusions. Antepartum immunization generated suboptimal antibody responses, suggesting that postpartum booster doses may be beneficial and warrant further studies. Considering that PCV-10 and PPV-23 had similar immunogenicity, but PPV-23 covered more serotypes, use of PPV-23 may be prioritized in women with HIV on antiretroviral therapy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALJoseHPilotto_etal_IOC_2022.pdfJoseHPilotto_etal_IOC_2022.pdfapplication/pdf488920https://www.arca.fiocruz.br/bitstream/icict/55540/2/JoseHPilotto_etal_IOC_2022.pdfb330c48268216d9ede7ce218cdd2e76aMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55540/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/555402023-09-14 16:02:04.034oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T19:02:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV |
| title |
Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV |
| spellingShingle |
Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV Duarte, Geraldo Arte Infecção pelo HIV PCV PPV Gravidez ART HIV infection PCV PPV Pregnancy |
| title_short |
Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV |
| title_full |
Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV |
| title_fullStr |
Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV |
| title_full_unstemmed |
Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV |
| title_sort |
Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV |
| author |
Duarte, Geraldo |
| author_facet |
Duarte, Geraldo Muresan, Petronella Ward, Shawn Laimon, Lauren Pelton, Stephen I. Canniff, Jennifer Golner, Amanda Golner Bone, Frederic Newton, Lassallete Fenton, Terence Coutinho, Conrado M. João, Esau C. Santos, Breno R. Pilotto, Jose Henrique da Silva Oliveira, Ricardo H. Pinto, Jorge A. Machado, Elizabeth S. Kreitchman, Regis Chakhtoura, Nahida Mussi-Pinhata, Marisa M. Weinberg, Adriana for NICHD P1091 Study Team |
| author_role |
author |
| author2 |
Muresan, Petronella Ward, Shawn Laimon, Lauren Pelton, Stephen I. Canniff, Jennifer Golner, Amanda Golner Bone, Frederic Newton, Lassallete Fenton, Terence Coutinho, Conrado M. João, Esau C. Santos, Breno R. Pilotto, Jose Henrique da Silva Oliveira, Ricardo H. Pinto, Jorge A. Machado, Elizabeth S. Kreitchman, Regis Chakhtoura, Nahida Mussi-Pinhata, Marisa M. Weinberg, Adriana for NICHD P1091 Study Team |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Duarte, Geraldo Muresan, Petronella Ward, Shawn Laimon, Lauren Pelton, Stephen I. Canniff, Jennifer Golner, Amanda Golner Bone, Frederic Newton, Lassallete Fenton, Terence Coutinho, Conrado M. João, Esau C. Santos, Breno R. Pilotto, Jose Henrique da Silva Oliveira, Ricardo H. Pinto, Jorge A. Machado, Elizabeth S. Kreitchman, Regis Chakhtoura, Nahida Mussi-Pinhata, Marisa M. Weinberg, Adriana for NICHD P1091 Study Team |
| dc.subject.other.en_US.fl_str_mv |
Arte Infecção pelo HIV PCV PPV Gravidez |
| topic |
Arte Infecção pelo HIV PCV PPV Gravidez ART HIV infection PCV PPV Pregnancy |
| dc.subject.en.en_US.fl_str_mv |
ART HIV infection PCV PPV Pregnancy |
| description |
Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Ginecologia e Obstetrícia. Ribeirão Preto, SP, Brasil. |
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2021 |
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2021 |
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2022-11-08T19:13:50Z |
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2022-11-08T19:13:50Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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DUARTE, Geraldo et al. Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV. The Journal of Infectious Diseases, v. 225, p. 1021–1031, 2022. |
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https://www.arca.fiocruz.br/handle/icict/55540 |
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1413-8670 |
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10.1093/infdis/jiab567 |
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DUARTE, Geraldo et al. Immunogenicity of Conjugated and Polysaccharide Pneumococcal Vaccines Administered During Pregnancy or Postpartum to Women With HIV. The Journal of Infectious Diseases, v. 225, p. 1021–1031, 2022. 1413-8670 10.1093/infdis/jiab567 |
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Oxford University Press |
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Oxford University Press |
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