Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial

Detalhes bibliográficos
Autor(a) principal: Prates, Fernanda Ventim de Oliveira
Data de Publicação: 2017
Outros Autores: Dourado, Mayra Elizabeth Ferreira, Silva, Silvana Conceição da, Schriefer, Albert, Guimarães, Luiz Henrique, Brito, Maria das Graças de Oliveira, Almeida, Juliana, Carvalho Filho, Edgar Marcelino, Machado, Paulo Roberto Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25533
Resumo: National Council of Scientific and Technological Development (MCTI/CNPq/MS-SCTIE-Decit 40/2012; Research for Neglected Diseases grant 404129/2012-9).
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spelling Prates, Fernanda Ventim de OliveiraDourado, Mayra Elizabeth FerreiraSilva, Silvana Conceição daSchriefer, AlbertGuimarães, Luiz HenriqueBrito, Maria das Graças de OliveiraAlmeida, JulianaCarvalho Filho, Edgar MarcelinoMachado, Paulo Roberto Lima2018-03-27T18:02:26Z2018-03-27T18:02:26Z2017PRATES, F. V. O. et al. Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial. Clinical Infectious Diseases, v. 64, n. 1, p. 67–71, 2017.1058-4838https://www.arca.fiocruz.br/handle/icict/2553310.1093/cid/ciw662National Council of Scientific and Technological Development (MCTI/CNPq/MS-SCTIE-Decit 40/2012; Research for Neglected Diseases grant 404129/2012-9).Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil The treatment of cutaneous leishmaniasis (CL) caused by Leishmania braziliensis in Brazil with pentavalent antimony (Sbv) is associated with a high rate of failure, up to 45% of cases. In addition, Sbvcan only administered parenterally and has important toxic effect. An effective, safe, and oral treatment for CL is required. Methods. A randomized controlled clinical trial was conducted to compare the efficacy and safety of high-dosage oral fluconazole (6.5–8.0 mg/kg/d for 28 days) versus a standard Sbv protocol (20 mg/kg/d for 20 days) for the treatment of CL in Bahia, Brazil. Results. A total of 53 subjects were included in the trial; 26 were treated with Sbv, and 27 with fluconazole. Intention-to-treat analysis showed initial cure rates (2 months after treatment) of 22.2% (6 of 27) in the fluconazole and 53.8% (14 of 26) in the Sbv group (P = .04). Six months after treatment, the final cure rate remained the same in both groups, without any relapses. The frequencies of adverse effects in the Sbv and fluconazole groups were similar, 34.6% versus 37% respectively. One patient treated with fluconazole discontinued treatment owing to malaise, headache, and moderate dizziness (Common Terminology Criteria for Adverse Events grade 2). Conclusions. Oral fluconazole at a dosage of 6.5–8 mg/kg/d for 28 days should not be considered an effective treatment for CL caused by L. braziliensis.engOxford University PressLeishmaniose cutâneaFluconazolLeishmania (V.) braziliensisantimonio pentavalenteCutaneous leishmaniasisFluconazoleLeishmania (V.) braziliensisPentavalent antimonyFluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25533/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPrates FV Fluconazole in the Treatment of Cutaneous ....pdfPrates FV Fluconazole in the Treatment of Cutaneous 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dc.title.pt_BR.fl_str_mv Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
title Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
spellingShingle Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
Prates, Fernanda Ventim de Oliveira
Leishmaniose cutânea
Fluconazol
Leishmania (V.) braziliensis
antimonio pentavalente
Cutaneous leishmaniasis
Fluconazole
Leishmania (V.) braziliensis
Pentavalent antimony
title_short Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
title_full Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
title_fullStr Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
title_full_unstemmed Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
title_sort Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial
author Prates, Fernanda Ventim de Oliveira
author_facet Prates, Fernanda Ventim de Oliveira
Dourado, Mayra Elizabeth Ferreira
Silva, Silvana Conceição da
Schriefer, Albert
Guimarães, Luiz Henrique
Brito, Maria das Graças de Oliveira
Almeida, Juliana
Carvalho Filho, Edgar Marcelino
Machado, Paulo Roberto Lima
author_role author
author2 Dourado, Mayra Elizabeth Ferreira
Silva, Silvana Conceição da
Schriefer, Albert
Guimarães, Luiz Henrique
Brito, Maria das Graças de Oliveira
Almeida, Juliana
Carvalho Filho, Edgar Marcelino
Machado, Paulo Roberto Lima
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Prates, Fernanda Ventim de Oliveira
Dourado, Mayra Elizabeth Ferreira
Silva, Silvana Conceição da
Schriefer, Albert
Guimarães, Luiz Henrique
Brito, Maria das Graças de Oliveira
Almeida, Juliana
Carvalho Filho, Edgar Marcelino
Machado, Paulo Roberto Lima
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea
Fluconazol
Leishmania (V.) braziliensis
antimonio pentavalente
topic Leishmaniose cutânea
Fluconazol
Leishmania (V.) braziliensis
antimonio pentavalente
Cutaneous leishmaniasis
Fluconazole
Leishmania (V.) braziliensis
Pentavalent antimony
dc.subject.en.pt_BR.fl_str_mv Cutaneous leishmaniasis
Fluconazole
Leishmania (V.) braziliensis
Pentavalent antimony
description National Council of Scientific and Technological Development (MCTI/CNPq/MS-SCTIE-Decit 40/2012; Research for Neglected Diseases grant 404129/2012-9).
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-27T18:02:26Z
dc.date.available.fl_str_mv 2018-03-27T18:02:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv PRATES, F. V. O. et al. Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial. Clinical Infectious Diseases, v. 64, n. 1, p. 67–71, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25533
dc.identifier.issn.pt_BR.fl_str_mv 1058-4838
dc.identifier.doi.none.fl_str_mv 10.1093/cid/ciw662
identifier_str_mv PRATES, F. V. O. et al. Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial. Clinical Infectious Diseases, v. 64, n. 1, p. 67–71, 2017.
1058-4838
10.1093/cid/ciw662
url https://www.arca.fiocruz.br/handle/icict/25533
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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