Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region

Detalhes bibliográficos
Autor(a) principal: Fernandes, Andréa Aparecida Morais
Data de Publicação: 2008
Outros Autores: Carvalho, Leonardo José de Moura, Zanini, Graziela Maria, Ventura, Ana Maria Revorêdo da Silva, Souza, José Maria, Cotias, Paulo Marcelo, Silva Filho, Isaac Lima, Daniel-Ribeiro, Cláudio Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28317
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
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spelling Fernandes, Andréa Aparecida MoraisCarvalho, Leonardo José de MouraZanini, Graziela MariaVentura, Ana Maria Revorêdo da SilvaSouza, José MariaCotias, Paulo MarceloSilva Filho, Isaac LimaDaniel-Ribeiro, Cláudio Tadeu2018-08-23T12:44:25Z2018-08-23T12:44:25Z2008FERNANDES, Andréa Aparecida Morais; et al. Similar Cytokine Responses and Degrees of Anemia in Patients with Plasmodium falciparum and Plasmodium vivax Infections in the Brazilian Amazon Region. Clinical and Vaccine Immunology, v.15, n.4, p.650-658, Apr. 2008.1556-6811https://www.arca.fiocruz.br/handle/icict/2831710.1128/CVI.00475-071556-679XengAmerican Society for MicrobiologyPlasmodium falciparumInfecçãoAnemiaCitocinasAmazônia BrasileiraPlasmodium falciparumPlasmodium vivaxInfectionsAnemiacytokinesBrazilian Amazon RegionSimilar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.IInstituto Evandro Chagas. Secretaria de Vigilância em Saúde. Ensaios Clínicos Ambulatoriais e Laboratoriais de Malária. Belém, PA, Brasil.Instituto Evandro Chagas. Secretaria de Vigilância em Saúde. Ensaios Clínicos Ambulatoriais e Laboratoriais de Malária. Belém, PA, Brasil.l.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.The mechanisms of malarial anemia induction are poorly understood, but cytokines and autoantibodies are considered to play important roles. This work aimed at evaluating the degree of anemia and the plasmatic profile of the cytokines tumor necrosis factor alpha (TNF-alpha), gamma interferon (IFN-gamma), interleukin-12 (IL-12), migration inhibitory factor (MIF), and IL-10 and the monocyte chemotactic protein-1 (MCP-1) chemokine, as well as evaluating the presence of antibodies directed to components of the normal erythrocyte membrane and to cardiolipin in individuals with malaria from the Brazilian Amazon. No difference was observed in the frequency of anemia between patients infected by Plasmodium vivax and those infected by Plasmodium falciparum, and there was no relationship between the levels of parasitemia and the manifestations of anemia in P. vivax and P. falciparum patients. Significant increases in the concentrations of TNF-alpha, IFN-gamma, MIF, and MCP-1 were observed in patients with P. falciparum and P. vivax malaria, whereas the concentrations of IL-10 was increased only in patients with P. vivax infection. Higher concentrations of IL-12 and IL-10 were observed in the P. falciparum anemic patients, while for TNF-alpha this profile was observed in the nonanemic ones. P. vivax-infected and P. falciparum-infected patients with positive immunoglobulin M (IgM) or IgM and IgG responses, respectively, against blood-stage forms of the parasites had significantly lower hemoglobin levels than did those with negative responses. There was no correlation between the presence of anti-erythrocyte and anti-cardiolipin antibodies and the presence or intensity of the anemia. Our data suggest that in areas of low endemicity and unstable transmission of malaria, P. vivax and P. falciparum infections present similar characteristics in terms of the induction of anemia and cytokine responses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28317/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALandrea_fernandes_etal_IOC_2009.pdfandrea_fernandes_etal_IOC_2009.pdfapplication/pdf799926https://www.arca.fiocruz.br/bitstream/icict/28317/2/andrea_fernandes_etal_IOC_2009.pdf8df635d6d4ac178ebde2bf8d772613fdMD52TEXTandrea_fernandes_etal_IOC_2009.pdf.txtandrea_fernandes_etal_IOC_2009.pdf.txtExtracted texttext/plain56565https://www.arca.fiocruz.br/bitstream/icict/28317/3/andrea_fernandes_etal_IOC_2009.pdf.txtd1e650583e0a3531b83f034f89b1f52fMD53icict/283172018-08-24 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dc.title.pt_BR.fl_str_mv Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
title Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
spellingShingle Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
Fernandes, Andréa Aparecida Morais
Plasmodium falciparum
Infecção
Anemia
Citocinas
Amazônia Brasileira
Plasmodium falciparum
Plasmodium vivax
Infections
Anemia
cytokines
Brazilian Amazon Region
title_short Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
title_full Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
title_fullStr Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
title_full_unstemmed Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
title_sort Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region
author Fernandes, Andréa Aparecida Morais
author_facet Fernandes, Andréa Aparecida Morais
Carvalho, Leonardo José de Moura
Zanini, Graziela Maria
Ventura, Ana Maria Revorêdo da Silva
Souza, José Maria
Cotias, Paulo Marcelo
Silva Filho, Isaac Lima
Daniel-Ribeiro, Cláudio Tadeu
author_role author
author2 Carvalho, Leonardo José de Moura
Zanini, Graziela Maria
Ventura, Ana Maria Revorêdo da Silva
Souza, José Maria
Cotias, Paulo Marcelo
Silva Filho, Isaac Lima
Daniel-Ribeiro, Cláudio Tadeu
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Andréa Aparecida Morais
Carvalho, Leonardo José de Moura
Zanini, Graziela Maria
Ventura, Ana Maria Revorêdo da Silva
Souza, José Maria
Cotias, Paulo Marcelo
Silva Filho, Isaac Lima
Daniel-Ribeiro, Cláudio Tadeu
dc.subject.other.pt_BR.fl_str_mv Plasmodium falciparum
Infecção
Anemia
Citocinas
Amazônia Brasileira
topic Plasmodium falciparum
Infecção
Anemia
Citocinas
Amazônia Brasileira
Plasmodium falciparum
Plasmodium vivax
Infections
Anemia
cytokines
Brazilian Amazon Region
dc.subject.en.pt_BR.fl_str_mv Plasmodium falciparum
Plasmodium vivax
Infections
Anemia
cytokines
Brazilian Amazon Region
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2018-08-23T12:44:25Z
dc.date.available.fl_str_mv 2018-08-23T12:44:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERNANDES, Andréa Aparecida Morais; et al. Similar Cytokine Responses and Degrees of Anemia in Patients with Plasmodium falciparum and Plasmodium vivax Infections in the Brazilian Amazon Region. Clinical and Vaccine Immunology, v.15, n.4, p.650-658, Apr. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28317
dc.identifier.issn.pt_BR.fl_str_mv 1556-6811
dc.identifier.doi.none.fl_str_mv 10.1128/CVI.00475-07
dc.identifier.eissn.none.fl_str_mv 1556-679X
identifier_str_mv FERNANDES, Andréa Aparecida Morais; et al. Similar Cytokine Responses and Degrees of Anemia in Patients with Plasmodium falciparum and Plasmodium vivax Infections in the Brazilian Amazon Region. Clinical and Vaccine Immunology, v.15, n.4, p.650-658, Apr. 2008.
1556-6811
10.1128/CVI.00475-07
1556-679X
url https://www.arca.fiocruz.br/handle/icict/28317
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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