Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44543 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil. |
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Parreiras, Patricia M.Lobato, Francisco C. F.Alencar, Andréa P.Figueiredo, Telma deGomes, Harrison M.Boéchat, NeioLage, Andrey P.Assis, Ronie A.Pereira, Márcia A. S.Souza, Patrícia R.Mota, Pedro M. P. C.Suffys, Philip N.2020-11-19T17:44:17Z2020-11-19T17:44:17Z2004PARREIRAS, Patrícia M. et al. Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 7, p. 749-752, Nov. 2004.0074-0276https://www.arca.fiocruz.br/handle/icict/4454310.1590/S0074-027620040007000151678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Mycobacterium bovisSuscetibilidade de medicamentosIsoniazidaMycobacterium bovisDrug susceptibilityIsoniazideRifoligotypingIsoniazidaDrug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniquesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Escola de Vetrinária. Belo Horizonte, MG, Brasil.Ministério da Agricultura, Pecuária e Abastecimento. Laboratório Regional de Apoio Animal. Pedro Leopoldo, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças de Tórax. Unidade de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Escola de Vetrinária. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Vetrinária. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil.Ministério da Agricultura, Pecuária e Abastecimento. Laboratório Regional de Apoio Animal. Pedro Leopoldo, MG, Brasil.Ministério da Agricultura, Pecuária e Abastecimento. Laboratório Regional de Apoio Animal. Pedro Leopoldo, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil.Transmission of Mycobacterium bovis from cattle to humans has been reported and can cause tuberculosis (Tb) and a problem in certain risk populations. Therefore, knowledge of resistance of M. bovis towards antibiotics used for therapy of human Tb could help avoiding cure delay and treatment cost increase when dealing with drug resistant organisms. We therefore evaluated the susceptibility of M. bovis isolates towards streptomycin, isoniazide, rifampicin, ethambutol, and ethionamide, the first line antibiotics for human Tb. Therefore, 185 clinical samples from cattle with clinical signs of tuberculosis were processed and submitted to culturing and bacterial isolates to identification and drug susceptibility testing using the proportion method. Among 89 mycobacterial strains, 65 were identified as M. bovis and none were resistant to any of the antibiotics used. Confirmation of present results by future studies, enrolling a large number of isolates and designed to properly represent Brazilian regions, may favor the idea of using isoniazide preventive therapy as part of a Tb control strategy in special situations. Also, nucleic acids from bacterial isolates were submitted to rifoligotyping, a recently described reverse hybridization assay for detection of mutations causing resistance towards rifampicin. Concordance between the conventional and the molecular test was 100%, demonstrating the use of such methodology for rapid evaluation of drug susceptibility in M. bovis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44543/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFranciscoLobato_PhylipSufffys_etal_IOC_2004.pdfFranciscoLobato_PhylipSufffys_etal_IOC_2004.pdfapplication/pdf44466https://www.arca.fiocruz.br/bitstream/icict/44543/2/FranciscoLobato_PhylipSufffys_etal_IOC_2004.pdf856a2812e831eb30a01d6589f5206cfaMD52TEXTFranciscoLobato_PhylipSufffys_etal_IOC_2004.pdf.txtFranciscoLobato_PhylipSufffys_etal_IOC_2004.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques |
title |
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques |
spellingShingle |
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques Parreiras, Patricia M. Mycobacterium bovis Suscetibilidade de medicamentos Isoniazida Mycobacterium bovis Drug susceptibility Isoniazide Rifoligotyping Isoniazida |
title_short |
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques |
title_full |
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques |
title_fullStr |
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques |
title_full_unstemmed |
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques |
title_sort |
Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques |
author |
Parreiras, Patricia M. |
author_facet |
Parreiras, Patricia M. Lobato, Francisco C. F. Alencar, Andréa P. Figueiredo, Telma de Gomes, Harrison M. Boéchat, Neio Lage, Andrey P. Assis, Ronie A. Pereira, Márcia A. S. Souza, Patrícia R. Mota, Pedro M. P. C. Suffys, Philip N. |
author_role |
author |
author2 |
Lobato, Francisco C. F. Alencar, Andréa P. Figueiredo, Telma de Gomes, Harrison M. Boéchat, Neio Lage, Andrey P. Assis, Ronie A. Pereira, Márcia A. S. Souza, Patrícia R. Mota, Pedro M. P. C. Suffys, Philip N. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Parreiras, Patricia M. Lobato, Francisco C. F. Alencar, Andréa P. Figueiredo, Telma de Gomes, Harrison M. Boéchat, Neio Lage, Andrey P. Assis, Ronie A. Pereira, Márcia A. S. Souza, Patrícia R. Mota, Pedro M. P. C. Suffys, Philip N. |
dc.subject.other.pt_BR.fl_str_mv |
Mycobacterium bovis Suscetibilidade de medicamentos Isoniazida |
topic |
Mycobacterium bovis Suscetibilidade de medicamentos Isoniazida Mycobacterium bovis Drug susceptibility Isoniazide Rifoligotyping Isoniazida |
dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium bovis Drug susceptibility Isoniazide Rifoligotyping |
dc.subject.decs.pt_BR.fl_str_mv |
Isoniazida |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Biologia Molecular Aplicada à Micobactérias. Rio de Janeiro, RJ, Brasil. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2020-11-19T17:44:17Z |
dc.date.available.fl_str_mv |
2020-11-19T17:44:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PARREIRAS, Patrícia M. et al. Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 7, p. 749-752, Nov. 2004. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44543 |
dc.identifier.issn.pt_BR.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762004000700015 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
PARREIRAS, Patrícia M. et al. Drug susceptibility of Brazilian strains of Mycobacterium bovis using traditional and molecular techniques. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 7, p. 749-752, Nov. 2004. 0074-0276 10.1590/S0074-02762004000700015 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/44543 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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