Mast cell function and death in Trypanosoma cruzi infection

Detalhes bibliográficos
Autor(a) principal: Batista, Marcelo Meuser
Data de Publicação: 2011
Outros Autores: Corrêa, José Raimundo, Carvalho, Vinícius Frias, Britto, Constança Felícia De Paoli de Carvalho, Moreira, Otacilio da Cruz, Batista, Marcos Meuser, Soares, Maurílio José, Farias Filho, Francisco Alves, Silva, Patrícia Machado R. E., Lannes-Vieira, Joseli, Silva, Robson Coutinho, Pons, Andrea Henrique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15957
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino, e Bioprodutos. Rio de Janeiro, RJ, Brasil.
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spelling Batista, Marcelo MeuserCorrêa, José RaimundoCarvalho, Vinícius FriasBritto, Constança Felícia De Paoli de CarvalhoMoreira, Otacilio da CruzBatista, Marcos MeuserSoares, Maurílio JoséFarias Filho, Francisco AlvesSilva, Patrícia Machado R. E.Lannes-Vieira, JoseliSilva, Robson CoutinhoPons, Andrea Henrique2016-09-27T13:04:00Z2016-09-27T13:04:00Z2011BATISTA, Marcelo Meuser; et al. Mast Cell Function and Death in Trypanosoma cruzi Infection. American Journal of Pathology, v.179, n.4, Oct. 2011.0002-9440https://www.arca.fiocruz.br/handle/icict/1595710.1016/j.ajpath.2011.06.0141525-2191engElsevierTrypanosoma cruziMastócitosInflamaçãoCardiomiopatiaTrypanosoma cruzimast cellsinflammatory diseasesCardiomiopathyMast cell function and death in Trypanosoma cruzi infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino, e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Universidade de Brasília. Brasília, DF, Brasil / Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino, e Bioprodutos. Rio de Janeiro, RJ, Brasil.Although the roles of mast cells (MCs) are essential in many inflammatory and fibrotic diseases, their role in Trypanosoma cruzi-induced cardiomyopathy is unexplored. In this study, we treated infected CBA mice with cromolyn, an MC stabilizer, and observed much greater parasitemia and interferon-γ levels, higher mortality, myocarditis, and cardiac damage. Although these data show that MCs are important in controlling acute infection, we observed MC apoptosis in the cardiac tissue and peritoneal cavity of untreated mice. In the heart, pericardial mucosal MC die, perhaps because of reduced amounts of local stem cell factor. Using RT-PCR in purified cardiac MCs, we observed that infection induced transcription of P2X(7) receptor and Fas, two molecules reportedly involved in cell death and inflammatory regulation. In gld/gld mice (FasL(-/-)), apoptosis of cardiac, but not peritoneal, MCs was decreased. Conversely, infection of P2X(7)(-/-) mice led to reduced peritoneal, but not cardiac, MC death. These data illustrate the immunomodulatory role played by MCs in T. cruzi infection and the complexity of molecular interactions that control inflammatory pathways in different tissues and compartments.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15957/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALfrancisco_fariasfilho_etal_IOC_2011.pdffrancisco_fariasfilho_etal_IOC_2011.pdfapplication/pdf3304018https://www.arca.fiocruz.br/bitstream/icict/15957/2/francisco_fariasfilho_etal_IOC_2011.pdf63484259575329fe5e8551622741a19cMD52TEXTfrancisco_fariasfilho_etal_IOC_2011.pdf.txtfrancisco_fariasfilho_etal_IOC_2011.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Mast cell function and death in Trypanosoma cruzi infection
title Mast cell function and death in Trypanosoma cruzi infection
spellingShingle Mast cell function and death in Trypanosoma cruzi infection
Batista, Marcelo Meuser
Trypanosoma cruzi
Mastócitos
Inflamação
Cardiomiopatia
Trypanosoma cruzi
mast cells
inflammatory diseases
Cardiomiopathy
title_short Mast cell function and death in Trypanosoma cruzi infection
title_full Mast cell function and death in Trypanosoma cruzi infection
title_fullStr Mast cell function and death in Trypanosoma cruzi infection
title_full_unstemmed Mast cell function and death in Trypanosoma cruzi infection
title_sort Mast cell function and death in Trypanosoma cruzi infection
author Batista, Marcelo Meuser
author_facet Batista, Marcelo Meuser
Corrêa, José Raimundo
Carvalho, Vinícius Frias
Britto, Constança Felícia De Paoli de Carvalho
Moreira, Otacilio da Cruz
Batista, Marcos Meuser
Soares, Maurílio José
Farias Filho, Francisco Alves
Silva, Patrícia Machado R. E.
Lannes-Vieira, Joseli
Silva, Robson Coutinho
Pons, Andrea Henrique
author_role author
author2 Corrêa, José Raimundo
Carvalho, Vinícius Frias
Britto, Constança Felícia De Paoli de Carvalho
Moreira, Otacilio da Cruz
Batista, Marcos Meuser
Soares, Maurílio José
Farias Filho, Francisco Alves
Silva, Patrícia Machado R. E.
Lannes-Vieira, Joseli
Silva, Robson Coutinho
Pons, Andrea Henrique
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Batista, Marcelo Meuser
Corrêa, José Raimundo
Carvalho, Vinícius Frias
Britto, Constança Felícia De Paoli de Carvalho
Moreira, Otacilio da Cruz
Batista, Marcos Meuser
Soares, Maurílio José
Farias Filho, Francisco Alves
Silva, Patrícia Machado R. E.
Lannes-Vieira, Joseli
Silva, Robson Coutinho
Pons, Andrea Henrique
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Mastócitos
Inflamação
Cardiomiopatia
topic Trypanosoma cruzi
Mastócitos
Inflamação
Cardiomiopatia
Trypanosoma cruzi
mast cells
inflammatory diseases
Cardiomiopathy
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
mast cells
inflammatory diseases
Cardiomiopathy
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino, e Bioprodutos. Rio de Janeiro, RJ, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2016-09-27T13:04:00Z
dc.date.available.fl_str_mv 2016-09-27T13:04:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BATISTA, Marcelo Meuser; et al. Mast Cell Function and Death in Trypanosoma cruzi Infection. American Journal of Pathology, v.179, n.4, Oct. 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15957
dc.identifier.issn.pt_BR.fl_str_mv 0002-9440
dc.identifier.doi.none.fl_str_mv 10.1016/j.ajpath.2011.06.014
dc.identifier.eissn.none.fl_str_mv 1525-2191
identifier_str_mv BATISTA, Marcelo Meuser; et al. Mast Cell Function and Death in Trypanosoma cruzi Infection. American Journal of Pathology, v.179, n.4, Oct. 2011.
0002-9440
10.1016/j.ajpath.2011.06.014
1525-2191
url https://www.arca.fiocruz.br/handle/icict/15957
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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