High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49119 |
Resumo: | Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Institute of Tropical Medicine, 2000 Antwerp, Belgium. |
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Cossa-Moiane, IdaléciaCossa, HermínioBauhofer, Adilson Fernando LoforteChilaúle, JorféliaGuimarães, Esperança LourençoBero, Diocreciano MatiasCassocera, MartaBambo, MiguelAnapakala, EldaChissaque, AssucênioSambo, JúliaLanga, Jerónimo SouzinhoManhique-Coutinho, Lena VâniaFantinatti, MariaOliveira, Luis António LopesCruz, Alda Maria daDeus, Nilsa de2021-09-20T20:54:09Z2021-09-20T20:54:09Z2021COSSA-MOIANE, Idalécia et al. High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique. Pathogens, v. 10, n. 293, 12 p, Mar. 2021.2076-0817https://www.arca.fiocruz.br/handle/icict/4911910.3390/pathogens10030293engMDPICryptosporidiumDiarreia agudaCriançasFatores de riscoMoçambiqueAcute diarrheaCryptosporidiumChildrenRIsk factorsMozambiqueHigh Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambiqueinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Institute of Tropical Medicine, 2000 Antwerp, Belgium.Centro de Investigação em Saúde de Manhiça (CISM), Unidade de Pesquisa Social, Manhiça Foundation (Fundação Manhiça, FM), Manhiça 1929, Mozambique.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Universidade Nova Lisboa. Instituto de Higiene e Medicina Tropical. Lisboa, Portugal.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Universidade Nova Lisboa. Instituto de Higiene e Medicina Tropical. Lisboa, Portugal.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Universidade Nova Lisboa. Instituto de Higiene e Medicina Tropical. Lisboa, Portugal.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Universidade Nova Lisboa. Instituto de Higiene e Medicina Tropical. Lisboa, Portugal.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Universidade Nova Lisboa. Instituto de Higiene e Medicina Tropical. Lisboa, Portugal.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas.. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas.. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Universidade Eduardo Mondlane. Departamento de Ciências Biológicas,. Maputo, Mozambique.Cryptosporidium is one of the most important causes of diarrhea in children less than 2 years of age. In this study, we report the frequency, risk factors and species of Cryptosporidium detected by molecular diagnostic methods in children admitted to two public hospitals in Maputo City, Mozambique. We studied 319 patients under the age of five years who were admitted due to diarrhea between April 2015 and February 2016. Single stool samples were examined for the presence of Cryptosporidium spp. oocysts, microscopically by using a Modified Ziehl–Neelsen (mZN) staining method and by using Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) technique using 18S ribosomal RNA gene as a target. Overall, 57.7% (184/319) were males, the median age (Interquartile range, IQR) was 11.0 (7–15) months. Cryptosporidium spp. oocysts were detected in 11.0% (35/319) by microscopy and in 35.4% (68/192) using PCR-RFLP. The most affected age group were children older than two years, [adjusted odds ratio (aOR): 5.861; 95% confidence interval (CI): 1.532–22.417; p-value < 0.05]. Children with illiterate caregivers had higher risk of infection (aOR: 1.688; 95% CI: 1.001–2.845; p-value < 0.05). An anthroponotic species C. hominis was found in 93.0% (27/29) of samples. Our findings demonstrated that cryptosporidiosis in children with diarrhea might be caused by anthroponomic transmissioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49119/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMAriaFantinati_LuizAOliveira_etal_IOC_2021.pdfMAriaFantinati_LuizAOliveira_etal_IOC_2021.pdfapplication/pdf1162518https://www.arca.fiocruz.br/bitstream/icict/49119/2/MAriaFantinati_LuizAOliveira_etal_IOC_2021.pdf0afa4166ad8b1f2b666633f45d584a95MD52icict/491192021-09-20 17:54:09.949oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-09-20T20:54:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique |
| title |
High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique |
| spellingShingle |
High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique Cossa-Moiane, Idalécia Cryptosporidium Diarreia aguda Crianças Fatores de risco Moçambique Acute diarrhea Cryptosporidium Children RIsk factors Mozambique |
| title_short |
High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique |
| title_full |
High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique |
| title_fullStr |
High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique |
| title_full_unstemmed |
High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique |
| title_sort |
High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique |
| author |
Cossa-Moiane, Idalécia |
| author_facet |
Cossa-Moiane, Idalécia Cossa, Hermínio Bauhofer, Adilson Fernando Loforte Chilaúle, Jorfélia Guimarães, Esperança Lourenço Bero, Diocreciano Matias Cassocera, Marta Bambo, Miguel Anapakala, Elda Chissaque, Assucênio Sambo, Júlia Langa, Jerónimo Souzinho Manhique-Coutinho, Lena Vânia Fantinatti, Maria Oliveira, Luis António Lopes Cruz, Alda Maria da Deus, Nilsa de |
| author_role |
author |
| author2 |
Cossa, Hermínio Bauhofer, Adilson Fernando Loforte Chilaúle, Jorfélia Guimarães, Esperança Lourenço Bero, Diocreciano Matias Cassocera, Marta Bambo, Miguel Anapakala, Elda Chissaque, Assucênio Sambo, Júlia Langa, Jerónimo Souzinho Manhique-Coutinho, Lena Vânia Fantinatti, Maria Oliveira, Luis António Lopes Cruz, Alda Maria da Deus, Nilsa de |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cossa-Moiane, Idalécia Cossa, Hermínio Bauhofer, Adilson Fernando Loforte Chilaúle, Jorfélia Guimarães, Esperança Lourenço Bero, Diocreciano Matias Cassocera, Marta Bambo, Miguel Anapakala, Elda Chissaque, Assucênio Sambo, Júlia Langa, Jerónimo Souzinho Manhique-Coutinho, Lena Vânia Fantinatti, Maria Oliveira, Luis António Lopes Cruz, Alda Maria da Deus, Nilsa de |
| dc.subject.other.pt_BR.fl_str_mv |
Cryptosporidium Diarreia aguda Crianças Fatores de risco Moçambique |
| topic |
Cryptosporidium Diarreia aguda Crianças Fatores de risco Moçambique Acute diarrhea Cryptosporidium Children RIsk factors Mozambique |
| dc.subject.en.pt_BR.fl_str_mv |
Acute diarrhea Cryptosporidium Children RIsk factors Mozambique |
| description |
Instituto Nacional de Saúde (INS), EN1. Distrito de Marracuene, Maputo 264, Mozambique / Institute of Tropical Medicine, 2000 Antwerp, Belgium. |
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2021 |
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2021-09-20T20:54:09Z |
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2021-09-20T20:54:09Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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COSSA-MOIANE, Idalécia et al. High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique. Pathogens, v. 10, n. 293, 12 p, Mar. 2021. |
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https://www.arca.fiocruz.br/handle/icict/49119 |
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2076-0817 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/pathogens10030293 |
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COSSA-MOIANE, Idalécia et al. High Frequency of Cryptosporidium hominis Infecting Infants Points to A Potential Anthroponotic Transmission in Maputo, Mozambique. Pathogens, v. 10, n. 293, 12 p, Mar. 2021. 2076-0817 10.3390/pathogens10030293 |
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