Leptospira and inflammation

Detalhes bibliográficos
Autor(a) principal: Albuquerque, C. F. Gonçalves de
Data de Publicação: 2012
Outros Autores: Burth, P., Silva, A. R., Younes-Ibrahim, M., Faria Neto, H. C. Castro, Faria, M. V. Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/19013
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
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spelling Albuquerque, C. F. Gonçalves deBurth, P.Silva, A. R.Younes-Ibrahim, M.Faria Neto, H. C. CastroFaria, M. V. Castro2017-05-25T18:22:23Z2017-05-25T18:22:23Z2012ALBUQUERQUE, C. F. Gonçalves; et al. Leptospira and Inflammation. Mediators of Inflammation, Volume 2012, Article ID 317950, 11p, 2012.0962-9351https://www.arca.fiocruz.br/handle/icict/1901310.1155/2012/3179501466-1861)engHindawi Publishing CorporationLeptospiroseInflamaçãoLeptospirosisInflammationLeptospira and inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.Leptospirosis is an important zoonosis and has a worldwide impact on public health. This paper will discuss both the role of immunogenic and pathogenic molecules during leptospirosis infection and possible new targets for immunotherapy against leptospira components. Leptospira, possess a wide variety of mechanisms that allow them to evade the host immune system and cause infection. Many molecules contribute to the ability of Leptospira to adhere, invade, and colonize. The recent sequencing of the Leptospira genome has increased our knowledge about this pathogen. Although the virulence factors, molecular targets, mechanisms of inflammation, and signaling pathways triggered by leptospiral antigens have been studied, some questions are still unanswered. Toll-like receptors (TLRs) are the primary sensors of invading pathogens. TLRs recognize conserved microbial pattern molecules and activate signaling pathways that are pivotal to innate and adaptive immune responses. Recently, a new molecular target has emerged--the Na/K-ATPase--which may contribute to inflammatory and metabolic alteration in this syndrome. Na/K-ATPase is a target for specific fatty acids of host origin and for bacterial components such as the glycolipoprotein fraction (GLP) that may lead to inflammasome activation. We propose that in addition to TLRs, Na/K-ATPase may play a role in the innate response to leptospirosis infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19013/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcf_albuquerque_etal_IOC_2012.pdfcf_albuquerque_etal_IOC_2012.pdfapplication/pdf1692788https://www.arca.fiocruz.br/bitstream/icict/19013/2/cf_albuquerque_etal_IOC_2012.pdfb9994d4358e9855225c2de06f7acc42eMD52TEXTcf_albuquerque_etal_IOC_2012.pdf.txtcf_albuquerque_etal_IOC_2012.pdf.txtExtracted texttext/plain66559https://www.arca.fiocruz.br/bitstream/icict/19013/3/cf_albuquerque_etal_IOC_2012.pdf.txt00dd354aa5fcb84ac0eca9d1b66de5d2MD53icict/190132018-08-15 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dc.title.pt_BR.fl_str_mv Leptospira and inflammation
title Leptospira and inflammation
spellingShingle Leptospira and inflammation
Albuquerque, C. F. Gonçalves de
Leptospirose
Inflamação
Leptospirosis
Inflammation
title_short Leptospira and inflammation
title_full Leptospira and inflammation
title_fullStr Leptospira and inflammation
title_full_unstemmed Leptospira and inflammation
title_sort Leptospira and inflammation
author Albuquerque, C. F. Gonçalves de
author_facet Albuquerque, C. F. Gonçalves de
Burth, P.
Silva, A. R.
Younes-Ibrahim, M.
Faria Neto, H. C. Castro
Faria, M. V. Castro
author_role author
author2 Burth, P.
Silva, A. R.
Younes-Ibrahim, M.
Faria Neto, H. C. Castro
Faria, M. V. Castro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Albuquerque, C. F. Gonçalves de
Burth, P.
Silva, A. R.
Younes-Ibrahim, M.
Faria Neto, H. C. Castro
Faria, M. V. Castro
dc.subject.other.pt_BR.fl_str_mv Leptospirose
Inflamação
topic Leptospirose
Inflamação
Leptospirosis
Inflammation
dc.subject.en.pt_BR.fl_str_mv Leptospirosis
Inflammation
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2017-05-25T18:22:23Z
dc.date.available.fl_str_mv 2017-05-25T18:22:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALBUQUERQUE, C. F. Gonçalves; et al. Leptospira and Inflammation. Mediators of Inflammation, Volume 2012, Article ID 317950, 11p, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/19013
dc.identifier.issn.pt_BR.fl_str_mv 0962-9351
dc.identifier.doi.none.fl_str_mv 10.1155/2012/317950
dc.identifier.eissn.none.fl_str_mv 1466-1861)
identifier_str_mv ALBUQUERQUE, C. F. Gonçalves; et al. Leptospira and Inflammation. Mediators of Inflammation, Volume 2012, Article ID 317950, 11p, 2012.
0962-9351
10.1155/2012/317950
1466-1861)
url https://www.arca.fiocruz.br/handle/icict/19013
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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