Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)

Detalhes bibliográficos
Autor(a) principal: Thornhill, Joyce
Data de Publicação: 2010
Outros Autores: Kusel, John Robert, Oliviera, Fabricia Alvisi de, Ribeiro, Fabio, Lima, Symone Fulgêncio, Coelho, Paulo Marcos Zach, McVeigh, Paul, Mattos, Ana Carolina Alves de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5896
Resumo: University of Glasgow. Glasgow, Scotland. UK
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spelling Thornhill, JoyceKusel, John RobertOliviera, Fabricia Alvisi deRibeiro, FabioLima, Symone FulgêncioCoelho, Paulo Marcos ZachMcVeigh, PaulMattos, Ana Carolina Alves de2012-11-28T14:40:01Z2012-11-28T14:40:01Z2010THORNHILL, Joyce et al. Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni). Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 105(4): 387-390, July 20100074-0276https://www.arca.fiocruz.br/handle/icict/5896engUptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Glasgow. Glasgow, Scotland. UKUniversity of Glasgow. Glasgow, Scotland. UKFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilQueen’s University Belfast. Belfast, Northern Ireland, UKFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilHere, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schisto-somulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulumSchistosoma mansonimembrane impermeant Lucifer yellownephridioporehost/parasite interfacelinoleic acidinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL127.2010.pdf127.2010.pdfapplication/pdf751700https://www.arca.fiocruz.br/bitstream/icict/5896/1/127.2010.pdfde1ec697c8b01840faf77a1a2961da51MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5896/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXT127.2010.pdf.txt127.2010.pdf.txtExtracted texttext/plain18206https://www.arca.fiocruz.br/bitstream/icict/5896/5/127.2010.pdf.txt97aebdd49eaba0df5e830fdb268a157fMD55THUMBNAIL127.2010.pdf.jpg127.2010.pdf.jpgGenerated Thumbnailimage/jpeg2414https://www.arca.fiocruz.br/bitstream/icict/5896/4/127.2010.pdf.jpg972afbbacb7d1d0140fd6b71a2065652MD54icict/58962018-05-18 11:48:44.132oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-05-18T14:48:44Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
spellingShingle Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
Thornhill, Joyce
Schistosoma mansoni
membrane impermeant Lucifer yellow
nephridiopore
host/parasite interface
linoleic acid
title_short Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title_full Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title_fullStr Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title_full_unstemmed Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title_sort Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
author Thornhill, Joyce
author_facet Thornhill, Joyce
Kusel, John Robert
Oliviera, Fabricia Alvisi de
Ribeiro, Fabio
Lima, Symone Fulgêncio
Coelho, Paulo Marcos Zach
McVeigh, Paul
Mattos, Ana Carolina Alves de
author_role author
author2 Kusel, John Robert
Oliviera, Fabricia Alvisi de
Ribeiro, Fabio
Lima, Symone Fulgêncio
Coelho, Paulo Marcos Zach
McVeigh, Paul
Mattos, Ana Carolina Alves de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Thornhill, Joyce
Kusel, John Robert
Oliviera, Fabricia Alvisi de
Ribeiro, Fabio
Lima, Symone Fulgêncio
Coelho, Paulo Marcos Zach
McVeigh, Paul
Mattos, Ana Carolina Alves de
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
membrane impermeant Lucifer yellow
nephridiopore
host/parasite interface
linoleic acid
topic Schistosoma mansoni
membrane impermeant Lucifer yellow
nephridiopore
host/parasite interface
linoleic acid
description University of Glasgow. Glasgow, Scotland. UK
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-11-28T14:40:01Z
dc.date.available.fl_str_mv 2012-11-28T14:40:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv THORNHILL, Joyce et al. Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni). Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 105(4): 387-390, July 2010
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5896
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv THORNHILL, Joyce et al. Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni). Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 105(4): 387-390, July 2010
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5896
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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