Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.

Detalhes bibliográficos
Autor(a) principal: Gomes, Flávia Lima Ribeiro
Data de Publicação: 2005
Outros Autores: Souza, Maria Carolina Abieri Moniz de, Borges, Valeria de Matos, Nunes, Marise Pinheiro, Barradas, Marcio Mantuano, Bizarro, Heloisa D’Ávila da Silva, Bozza, Patrícia Torres, Calich, Vera Lucia Garcia, DosReis, George Alexandre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9471
Resumo: Federal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
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spelling Gomes, Flávia Lima RibeiroSouza, Maria Carolina Abieri Moniz deBorges, Valeria de MatosNunes, Marise PinheiroBarradas, Marcio MantuanoBizarro, Heloisa D’Ávila da SilvaBozza, Patrícia TorresCalich, Vera Lucia GarciaDosReis, George Alexandre2015-02-10T13:55:47Z2015-02-10T13:55:47Z2005RIBEIRO-GOMES, F. L. et al. Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection. Journal of Infectious Diseases, v. 192, n. 6, p. 1127-1134, 2005.0022-1899https://www.arca.fiocruz.br/handle/icict/9471engOxford University PressTurnover of neutrophils mediated by Fas ligand drives Leishmania major infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFederal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFederal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversity of São Paulo. Instituto de Ciências Biomédicas. São Paulo, SP, BrasilFederal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilApoptosis mediated by Fas ligand (FasL) initiates inflammation characterized by neutrophilic infiltration. Neutrophils undergo apoptosis and are ingested by macrophages. Clearance of dead neutrophils leads to prostaglandin- and transforming growth factor-beta-dependent replication of Leishmania major in macrophages from susceptible mice. How L. major induces neutrophil turnover in a physiological setting is unknown. We show that BALB/c FasL-sufficient mice are more susceptible to L. major infection than are FasL-deficient mice. FasL promotes the apoptosis of infected resident macrophages and attracts neutrophils. Furthermore, FasL-sufficient neutrophils exacerbate L. major replication in macrophages, whereas FasL-deficient neutrophils induce parasite killing. These contrasting effects are due to delaying apoptosis and the clearance of FasL-deficient neutrophils. The transfer of neutrophils exacerbates infection in FasL-sufficient mice but reduces infection in FasL-deficient mice. Depletion of neutrophils abolishes the susceptibility of FasL-sufficient mice. These data illustrate a deleterious role of the FasL-mediated turnover of neutrophils on L. major infection.Leishmania major/crescimento & desenvolvimentoLeishmania major/imunologiaLeishmaniose Cutânea/imunologiaGlicoproteínas de Membrana/imunologiaNeutrófilos/imunologiaNeutrófilos/patologiaAnimaisApoptoseMorte Celular/imunologiaModelos Animais de DoençasSuscetibilidade a DoençasProteína Ligante FasLeishmaniose Cutânea/genéticaCamundongosCamundongos Endogâmicos BALB CCamundongos Knockoutinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9471/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALRibeiro-Gomes FL Turnover...pdfRibeiro-Gomes FL Turnover...pdfapplication/pdf2439307https://www.arca.fiocruz.br/bitstream/icict/9471/2/Ribeiro-Gomes%20FL%20Turnover...pdf63344954ef36fc4b33455b01fa48f302MD52TEXTRibeiro-Gomes FL Turnover...pdf.txtRibeiro-Gomes FL Turnover...pdf.txtExtracted texttext/plain37172https://www.arca.fiocruz.br/bitstream/icict/9471/3/Ribeiro-Gomes%20FL%20Turnover...pdf.txt441b8e74ba92fc6fd8815e7cb72193f0MD53icict/94712023-03-15 14:33:14.068oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.
title Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.
spellingShingle Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.
Gomes, Flávia Lima Ribeiro
Leishmania major/crescimento & desenvolvimento
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Glicoproteínas de Membrana/imunologia
Neutrófilos/imunologia
Neutrófilos/patologia
Animais
Apoptose
Morte Celular/imunologia
Modelos Animais de Doenças
Suscetibilidade a Doenças
Proteína Ligante Fas
Leishmaniose Cutânea/genética
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
title_short Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.
title_full Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.
title_fullStr Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.
title_full_unstemmed Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.
title_sort Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection.
author Gomes, Flávia Lima Ribeiro
author_facet Gomes, Flávia Lima Ribeiro
Souza, Maria Carolina Abieri Moniz de
Borges, Valeria de Matos
Nunes, Marise Pinheiro
Barradas, Marcio Mantuano
Bizarro, Heloisa D’Ávila da Silva
Bozza, Patrícia Torres
Calich, Vera Lucia Garcia
DosReis, George Alexandre
author_role author
author2 Souza, Maria Carolina Abieri Moniz de
Borges, Valeria de Matos
Nunes, Marise Pinheiro
Barradas, Marcio Mantuano
Bizarro, Heloisa D’Ávila da Silva
Bozza, Patrícia Torres
Calich, Vera Lucia Garcia
DosReis, George Alexandre
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Flávia Lima Ribeiro
Souza, Maria Carolina Abieri Moniz de
Borges, Valeria de Matos
Nunes, Marise Pinheiro
Barradas, Marcio Mantuano
Bizarro, Heloisa D’Ávila da Silva
Bozza, Patrícia Torres
Calich, Vera Lucia Garcia
DosReis, George Alexandre
dc.subject.decs.pt_BR.fl_str_mv Leishmania major/crescimento & desenvolvimento
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Glicoproteínas de Membrana/imunologia
Neutrófilos/imunologia
Neutrófilos/patologia
Animais
Apoptose
Morte Celular/imunologia
Modelos Animais de Doenças
Suscetibilidade a Doenças
Proteína Ligante Fas
Leishmaniose Cutânea/genética
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
topic Leishmania major/crescimento & desenvolvimento
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Glicoproteínas de Membrana/imunologia
Neutrófilos/imunologia
Neutrófilos/patologia
Animais
Apoptose
Morte Celular/imunologia
Modelos Animais de Doenças
Suscetibilidade a Doenças
Proteína Ligante Fas
Leishmaniose Cutânea/genética
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
description Federal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2015-02-10T13:55:47Z
dc.date.available.fl_str_mv 2015-02-10T13:55:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RIBEIRO-GOMES, F. L. et al. Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection. Journal of Infectious Diseases, v. 192, n. 6, p. 1127-1134, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9471
dc.identifier.issn.none.fl_str_mv 0022-1899
identifier_str_mv RIBEIRO-GOMES, F. L. et al. Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection. Journal of Infectious Diseases, v. 192, n. 6, p. 1127-1134, 2005.
0022-1899
url https://www.arca.fiocruz.br/handle/icict/9471
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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