Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36040 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil. |
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Castanha, Priscila M. S.Souza, Wayner V.Braga, CynthiaAraújo, Thália Velho Barreto deXimenes, Ricardo A. A.Albuquerque, Maria de Fátima P. M.Montarroyos, Ulisses R.Miranda-Filho, Demócrito B.Cordeiro, Marli T.Dhalia, RafaelMarques, Ernesto T. A.Rodrigues, Laura C.Martelli, Celina M. T.2019-10-01T14:52:03Z2019-10-01T14:52:03Z2019CASTANHA, Priscila M. S. et al. Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil. PLoS Neglected Tropical Diseases, v. 13, n. 3, p. 1-17, 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3604010.1371/journal.pntd.00072461935-2735engPerinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / University of Pittsburgh. Department of Infectious Diseases and Microbiology. Pittsburgh, Pennsylvania, United States of America.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Laboratory confirmation of Zika virus (ZIKV) infection during pregnancy is challenging due to cross-reactivity with dengue virus (DENV) and limited knowledge about the kinetics of anti-Zika antibody responses during pregnancy. We described ZIKV and DENV serological markers and the maternal-fetal transfer of antibodies among mothers and neonates after the ZIKV microcephaly outbreak in Northeast Brazil (2016). We included 89 microcephaly cases and 173 neonate controls at time of birth and their mothers. Microcephaly cases were defined as newborns with a particular head circumference (2 SD below the mean). Two controls without microcephaly were matched by the expected date of delivery and area of residence. We tested maternal serum for recent (ZIKV genome, IgM and IgG3 anti-NS1) and previous (ZIKV and DENV neutralizing antibodies [NAbs]) markers of infection. Multiple markers of recent or previous ZIKV and DENV infection in mothers were analyzed using principal component analysis (PCA). At delivery, 5.6% of microcephaly case mothers and 1.7% of control mothers were positive for ZIKV IgM. Positivity for ZIKV IgG3 anti-NS1 was 8.0% for case mothers and 3.5% for control mothers. ZIKV NAbs was slightly higher among mothers of cases (69.6%) than that of mothers of controls (57.2%; p = 0.054). DENV exposure was detected in 85.8% of all mothers. PCA discriminated two distinct components related to recent or previous ZIKV infection and DENV exposure. ZIKV NAbs were higher in newborns than in their corresponding mothers (p<0.001). We detected a high frequency of ZIKV exposure among mothers after the first wave of the ZIKV outbreak in Northeast Brazil. However, we found low sensitivity of the serological markers to recent infection (IgM and IgG3 anti-NS1) in perinatal samples of mothers of microcephaly cases. Since the neutralization test cannot precisely determine the time of infection, testing for ZIKV immune status should be performed as early as possible and throughout pregnancy to monitor acute Zika infection in endemic areas.ZikaDengueMicrocephalyInfectionAdolescenteAdultoAnticorpos Neutralizantes / sangueAnticorpos Antivirais / sangueBrasil / epidemiologiaEstudos de Casos e ControlesDengue / diagnósticoDengue / epidemiologiaVírus da Dengue / imunologiaFemininoHumanosImunoglobulina G / sangueImunoglobulina M / sangueRecém-NascidoMasculinoMicrocefalia / epidemiologiaMicrocefalia / etiologiaGravidezComplicações Infecciosas na Gravidez / diagnósticoComplicações Infecciosas na Gravidez / epidemiologiaAdulto JovemZika virus / imunologiaInfecção por Zika virus / complicaçõesInfecção por Zika virus / diagnósticoInfecção por Zika virus / epidemiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83085https://www.arca.fiocruz.br/bitstream/icict/36040/1/license.txt4194663c61da82c21746deb8d6361188MD51ORIGINALPerinatal analyses of Zika- and dengue virus-specific neutralizing antibodies.pdfPerinatal analyses of Zika- and dengue virus-specific neutralizing antibodies.pdfapplication/pdf1010139https://www.arca.fiocruz.br/bitstream/icict/36040/2/Perinatal%20analyses%20of%20Zika-%20and%20dengue%20virus-specific%20neutralizing%20antibodies.pdf2fdf1f05681cd71673d2d01321414451MD52TEXTPerinatal analyses of Zika- and dengue virus-specific neutralizing antibodies.pdf.txtPerinatal analyses of Zika- and dengue virus-specific neutralizing antibodies.pdf.txtExtracted texttext/plain60776https://www.arca.fiocruz.br/bitstream/icict/36040/3/Perinatal%20analyses%20of%20Zika-%20and%20dengue%20virus-specific%20neutralizing%20antibodies.pdf.txta61f62fbfa1e91655102e35f91e9c685MD53icict/360402021-01-26 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| dc.title.pt_BR.fl_str_mv |
Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil |
| title |
Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil |
| spellingShingle |
Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil Castanha, Priscila M. S. Zika Dengue Microcephaly Infection Adolescente Adulto Anticorpos Neutralizantes / sangue Anticorpos Antivirais / sangue Brasil / epidemiologia Estudos de Casos e Controles Dengue / diagnóstico Dengue / epidemiologia Vírus da Dengue / imunologia Feminino Humanos Imunoglobulina G / sangue Imunoglobulina M / sangue Recém-Nascido Masculino Microcefalia / epidemiologia Microcefalia / etiologia Gravidez Complicações Infecciosas na Gravidez / diagnóstico Complicações Infecciosas na Gravidez / epidemiologia Adulto Jovem Zika virus / imunologia Infecção por Zika virus / complicações Infecção por Zika virus / diagnóstico Infecção por Zika virus / epidemiologia |
| title_short |
Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil |
| title_full |
Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil |
| title_fullStr |
Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil |
| title_full_unstemmed |
Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil |
| title_sort |
Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil |
| author |
Castanha, Priscila M. S. |
| author_facet |
Castanha, Priscila M. S. Souza, Wayner V. Braga, Cynthia Araújo, Thália Velho Barreto de Ximenes, Ricardo A. A. Albuquerque, Maria de Fátima P. M. Montarroyos, Ulisses R. Miranda-Filho, Demócrito B. Cordeiro, Marli T. Dhalia, Rafael Marques, Ernesto T. A. Rodrigues, Laura C. Martelli, Celina M. T. |
| author_role |
author |
| author2 |
Souza, Wayner V. Braga, Cynthia Araújo, Thália Velho Barreto de Ximenes, Ricardo A. A. Albuquerque, Maria de Fátima P. M. Montarroyos, Ulisses R. Miranda-Filho, Demócrito B. Cordeiro, Marli T. Dhalia, Rafael Marques, Ernesto T. A. Rodrigues, Laura C. Martelli, Celina M. T. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castanha, Priscila M. S. Souza, Wayner V. Braga, Cynthia Araújo, Thália Velho Barreto de Ximenes, Ricardo A. A. Albuquerque, Maria de Fátima P. M. Montarroyos, Ulisses R. Miranda-Filho, Demócrito B. Cordeiro, Marli T. Dhalia, Rafael Marques, Ernesto T. A. Rodrigues, Laura C. Martelli, Celina M. T. |
| dc.subject.en.pt_BR.fl_str_mv |
Zika Dengue Microcephaly Infection |
| topic |
Zika Dengue Microcephaly Infection Adolescente Adulto Anticorpos Neutralizantes / sangue Anticorpos Antivirais / sangue Brasil / epidemiologia Estudos de Casos e Controles Dengue / diagnóstico Dengue / epidemiologia Vírus da Dengue / imunologia Feminino Humanos Imunoglobulina G / sangue Imunoglobulina M / sangue Recém-Nascido Masculino Microcefalia / epidemiologia Microcefalia / etiologia Gravidez Complicações Infecciosas na Gravidez / diagnóstico Complicações Infecciosas na Gravidez / epidemiologia Adulto Jovem Zika virus / imunologia Infecção por Zika virus / complicações Infecção por Zika virus / diagnóstico Infecção por Zika virus / epidemiologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Adolescente Adulto Anticorpos Neutralizantes / sangue Anticorpos Antivirais / sangue Brasil / epidemiologia Estudos de Casos e Controles Dengue / diagnóstico Dengue / epidemiologia Vírus da Dengue / imunologia Feminino Humanos Imunoglobulina G / sangue Imunoglobulina M / sangue Recém-Nascido Masculino Microcefalia / epidemiologia Microcefalia / etiologia Gravidez Complicações Infecciosas na Gravidez / diagnóstico Complicações Infecciosas na Gravidez / epidemiologia Adulto Jovem Zika virus / imunologia Infecção por Zika virus / complicações Infecção por Zika virus / diagnóstico Infecção por Zika virus / epidemiologia |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasil. |
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2019 |
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2019-10-01T14:52:03Z |
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2019-10-01T14:52:03Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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CASTANHA, Priscila M. S. et al. Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil. PLoS Neglected Tropical Diseases, v. 13, n. 3, p. 1-17, 2019. |
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https://www.arca.fiocruz.br/handle/icict/36040 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0007246 |
| dc.identifier.eissn.pt_BR.fl_str_mv |
1935-2735 |
| identifier_str_mv |
CASTANHA, Priscila M. S. et al. Perinatal analyses of Zika- and dengue virus-specific neutralizing antibodies: A microcephaly case-control study in an area of high dengue endemicity in Brazil. PLoS Neglected Tropical Diseases, v. 13, n. 3, p. 1-17, 2019. 1935-2727 10.1371/journal.pntd.0007246 1935-2735 |
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https://www.arca.fiocruz.br/handle/icict/36040 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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