Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth

Detalhes bibliográficos
Autor(a) principal: Fernandes, Priscilla Augusta de Sousa
Data de Publicação: 2021
Outros Autores: Silva, Josefa Carolaine Pereira da, Sales, Débora Lima, Ribeiro, Paulo Riceli Vasconcelos, Brito, Edy Sousa de, Kerntopf, Marta Regina, Delmondes, Gyllyandeson de Araújo, Pinheiro, Jacqueline Cosmo Andrade, Salazar, Gerson Javier Torres, Batista, Francisco Lucas Alves, Magalhães, Francisco Ernani Alves, Gomez, Maria Celeste Vega, Rolón, Míriam, Coronel, Cathia, Ribeiro Filho, Jaime, Bezerra, José Weverton Almeida, Siyadatpanah, Abolghasem, Nissapatorn, Veeranoot, Pereira, Maria de Lourdes, Coutinho, Henrique Douglas Melo, Braga, Maria Flaviana Bezerra Morais
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49126
Resumo: 1 Department of Biological Chemistry, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; priscilla.fernandes@urca.br (P.A.d.S.F.); debora.lima.sales@gmail.com (D.L.S.); martareginakerntopfm@outlook.com (M.R.K.); gyllyandesondelmondes@gmail.com (G.d.A.D.); timotygertor@yahoo.com (G.J.T.S.); lucas-a-b-181@hotmail.com (F.L.A.B.) 2 Department of Biological Sciences, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; carol.bio1881@outlook.com (J.C.P.d.S.); flavianamoraib@yahoo.com.br (M.F.B.M.-B.) 3 Embrapa Agroindústria Tropical, Tropical R. Pernambuco, 2270–Pici, Fortaleza 60511-110, Brazil; paulo.riceli@embrapa.br (P.R.V.R.); edy.brito@embrapa.br (E.S.d.B.) 4 Laboratório de Bioensaios, Universidade Federal do Cariri—UFCA, R. Olegário Emídio de Araújo, s/n, Centro, Brejo Santo 63260-000, Brazil; andradejacquelinec@gmail.com 5 Inhamuns Region Education, Science and Technology Center, Universidade Estadual do Ceará—UECE, BR-020—Bezerra de Sousa, Tauá 63660-000, Brazil; fernanimagalhaes@yahoo.com.br 6 Center for the Development of Scientific Research, Asuncion 1255, Paraguay; mcvegagomez@gmail.com (M.C.V.G.); rolonmiriam@gmail.com (M.R.) 7 Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil; cathiacoronel@gmail.com (C.C.); jaimeribeirofilho@gmail.com (J.R.-F.) 8 Department of Botany, Universidade Federal de Pernambuco—UFPE, Av. Prof. Moraes Rego, 1235, Recife 50670-901, Brazil; weverton.almeida@urca.br 9 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran; asiyadatpanah@yahoo.com 10 School of Allied Health Sciences, World Union for Herbal Drug Discovery (WUHeDD) and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, Thailand; veeranoot.ni@wu.ac.th 11 CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal
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spelling Fernandes, Priscilla Augusta de SousaSilva, Josefa Carolaine Pereira daSales, Débora LimaRibeiro, Paulo Riceli VasconcelosBrito, Edy Sousa deKerntopf, Marta ReginaDelmondes, Gyllyandeson de AraújoPinheiro, Jacqueline Cosmo AndradeSalazar, Gerson Javier TorresBatista, Francisco Lucas AlvesMagalhães, Francisco Ernani AlvesGomez, Maria Celeste VegaRolón, MíriamCoronel, CathiaRibeiro Filho, JaimeBezerra, José Weverton AlmeidaSiyadatpanah, AbolghasemNissapatorn, VeeranootPereira, Maria de LourdesCoutinho, Henrique Douglas MeloBraga, Maria Flaviana Bezerra Morais2021-09-21T17:47:25Z2021-09-21T17:47:25Z2021FERNANDES, Priscilla Augusta de Sousa et al. Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth. Antibiotics, v. 10, 2021.2079-6382https://www.arca.fiocruz.br/handle/icict/4912610.3390/antibiotics100910741 Department of Biological Chemistry, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; priscilla.fernandes@urca.br (P.A.d.S.F.); debora.lima.sales@gmail.com (D.L.S.); martareginakerntopfm@outlook.com (M.R.K.); gyllyandesondelmondes@gmail.com (G.d.A.D.); timotygertor@yahoo.com (G.J.T.S.); lucas-a-b-181@hotmail.com (F.L.A.B.) 2 Department of Biological Sciences, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; carol.bio1881@outlook.com (J.C.P.d.S.); flavianamoraib@yahoo.com.br (M.F.B.M.-B.) 3 Embrapa Agroindústria Tropical, Tropical R. Pernambuco, 2270–Pici, Fortaleza 60511-110, Brazil; paulo.riceli@embrapa.br (P.R.V.R.); edy.brito@embrapa.br (E.S.d.B.) 4 Laboratório de Bioensaios, Universidade Federal do Cariri—UFCA, R. Olegário Emídio de Araújo, s/n, Centro, Brejo Santo 63260-000, Brazil; andradejacquelinec@gmail.com 5 Inhamuns Region Education, Science and Technology Center, Universidade Estadual do Ceará—UECE, BR-020—Bezerra de Sousa, Tauá 63660-000, Brazil; fernanimagalhaes@yahoo.com.br 6 Center for the Development of Scientific Research, Asuncion 1255, Paraguay; mcvegagomez@gmail.com (M.C.V.G.); rolonmiriam@gmail.com (M.R.) 7 Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil; cathiacoronel@gmail.com (C.C.); jaimeribeirofilho@gmail.com (J.R.-F.) 8 Department of Botany, Universidade Federal de Pernambuco—UFPE, Av. Prof. Moraes Rego, 1235, Recife 50670-901, Brazil; weverton.almeida@urca.br 9 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran; asiyadatpanah@yahoo.com 10 School of Allied Health Sciences, World Union for Herbal Drug Discovery (WUHeDD) and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, Thailand; veeranoot.ni@wu.ac.th 11 CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalFundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico—FUNCAP through a Master’s scholarship.“Múltipla – ver em notas”Croton heliotropiifolius Kunth (Euphorbiaceae), whose occurrence has already been registered in the most varied Brazilian biomes, is commonly found in the Chapada do Araripe, Ceará. The species is traditionally used to treat fungal, parasitic, and degenerative diseases. This study investigated the chemical composition and pharmacological potential (antioxidant, antifungal, antiparasitic, and cytotoxic) of an aqueous extract obtained from the roots of C. heliotropiifolius. Following a qualitative phytochemical screening, the chemical constituents were identified by ultra-efficiency liquid chromatography coupled witha quadrupole/time-of-flight system (UPLC-QTOF). The antioxidant potential was verified by thin-layer chromatography (TLC). The direct and combined antifungal activity of the extract against opportunistic Candida strains was investigated using the microdilution method. The minimal fungicidal concentration (MFC) was determined by subculture, while the modulation of the morphological transition (fungal virulence) was evaluated by light microscopy. The in vitro antiparasitic activity was analyzed using epimastigotes of Trypanosoma cruzi and promastigotes of Leishmania braziliensis and Leishmania infantum, while cytotoxicity was determined in cultures of mouse fibroblasts. The phytochemical analysis identified the presence of acids, terpenes, flavonoids, lignans, and alkaloids. Among these constituents, the presence of polar and non-polar phenolic compounds with known antioxidant action was highlighted. While the extract showed clinically ineffective antifungal effects, it could enhance the effectiveness of fluconazole, in addition to inhibiting the morphological transition associated with increased virulence in Candida strains. Although the extract showed low cytotoxicity against fibroblasts, it also had weak antiparasitic effects. In conclusion, Croton heliotropiifolius is a source of natural products with antifungal and antioxidant potential.engMDPICrotonCompostos fenólicosAntioxidantesCromatografiaAntiparasitáriosCroton heliotropiifoliusPhenolic compoundsAntioxidantAntifungalCytotoxicityChemical Constituents and Biological Activities of Croton heliotropiifolius Kunthinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49126/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALFernandes, Priscilla Augusto de Sousa Chemical....pdfFernandes, Priscilla Augusto de Sousa Chemical....pdfapplication/pdf1689261https://www.arca.fiocruz.br/bitstream/icict/49126/2/Fernandes%2c%20Priscilla%20Augusto%20de%20Sousa%20Chemical....pdf14d17d813ac22af5c596a97d6533378bMD52icict/491262023-03-15 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dc.title.pt_BR.fl_str_mv Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
title Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
spellingShingle Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
Fernandes, Priscilla Augusta de Sousa
Croton
Compostos fenólicos
Antioxidantes
Cromatografia
Antiparasitários
Croton heliotropiifolius
Phenolic compounds
Antioxidant
Antifungal
Cytotoxicity
title_short Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
title_full Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
title_fullStr Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
title_full_unstemmed Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
title_sort Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth
author Fernandes, Priscilla Augusta de Sousa
author_facet Fernandes, Priscilla Augusta de Sousa
Silva, Josefa Carolaine Pereira da
Sales, Débora Lima
Ribeiro, Paulo Riceli Vasconcelos
Brito, Edy Sousa de
Kerntopf, Marta Regina
Delmondes, Gyllyandeson de Araújo
Pinheiro, Jacqueline Cosmo Andrade
Salazar, Gerson Javier Torres
Batista, Francisco Lucas Alves
Magalhães, Francisco Ernani Alves
Gomez, Maria Celeste Vega
Rolón, Míriam
Coronel, Cathia
Ribeiro Filho, Jaime
Bezerra, José Weverton Almeida
Siyadatpanah, Abolghasem
Nissapatorn, Veeranoot
Pereira, Maria de Lourdes
Coutinho, Henrique Douglas Melo
Braga, Maria Flaviana Bezerra Morais
author_role author
author2 Silva, Josefa Carolaine Pereira da
Sales, Débora Lima
Ribeiro, Paulo Riceli Vasconcelos
Brito, Edy Sousa de
Kerntopf, Marta Regina
Delmondes, Gyllyandeson de Araújo
Pinheiro, Jacqueline Cosmo Andrade
Salazar, Gerson Javier Torres
Batista, Francisco Lucas Alves
Magalhães, Francisco Ernani Alves
Gomez, Maria Celeste Vega
Rolón, Míriam
Coronel, Cathia
Ribeiro Filho, Jaime
Bezerra, José Weverton Almeida
Siyadatpanah, Abolghasem
Nissapatorn, Veeranoot
Pereira, Maria de Lourdes
Coutinho, Henrique Douglas Melo
Braga, Maria Flaviana Bezerra Morais
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Priscilla Augusta de Sousa
Silva, Josefa Carolaine Pereira da
Sales, Débora Lima
Ribeiro, Paulo Riceli Vasconcelos
Brito, Edy Sousa de
Kerntopf, Marta Regina
Delmondes, Gyllyandeson de Araújo
Pinheiro, Jacqueline Cosmo Andrade
Salazar, Gerson Javier Torres
Batista, Francisco Lucas Alves
Magalhães, Francisco Ernani Alves
Gomez, Maria Celeste Vega
Rolón, Míriam
Coronel, Cathia
Ribeiro Filho, Jaime
Bezerra, José Weverton Almeida
Siyadatpanah, Abolghasem
Nissapatorn, Veeranoot
Pereira, Maria de Lourdes
Coutinho, Henrique Douglas Melo
Braga, Maria Flaviana Bezerra Morais
dc.subject.other.pt_BR.fl_str_mv Croton
Compostos fenólicos
Antioxidantes
Cromatografia
Antiparasitários
topic Croton
Compostos fenólicos
Antioxidantes
Cromatografia
Antiparasitários
Croton heliotropiifolius
Phenolic compounds
Antioxidant
Antifungal
Cytotoxicity
dc.subject.en.pt_BR.fl_str_mv Croton heliotropiifolius
Phenolic compounds
Antioxidant
Antifungal
Cytotoxicity
description 1 Department of Biological Chemistry, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; priscilla.fernandes@urca.br (P.A.d.S.F.); debora.lima.sales@gmail.com (D.L.S.); martareginakerntopfm@outlook.com (M.R.K.); gyllyandesondelmondes@gmail.com (G.d.A.D.); timotygertor@yahoo.com (G.J.T.S.); lucas-a-b-181@hotmail.com (F.L.A.B.) 2 Department of Biological Sciences, Universidade Regional do Cariri—URCA, Av. Cel Antônio Luis, 1161, Pimenta, Crato 63105-010, Brazil; carol.bio1881@outlook.com (J.C.P.d.S.); flavianamoraib@yahoo.com.br (M.F.B.M.-B.) 3 Embrapa Agroindústria Tropical, Tropical R. Pernambuco, 2270–Pici, Fortaleza 60511-110, Brazil; paulo.riceli@embrapa.br (P.R.V.R.); edy.brito@embrapa.br (E.S.d.B.) 4 Laboratório de Bioensaios, Universidade Federal do Cariri—UFCA, R. Olegário Emídio de Araújo, s/n, Centro, Brejo Santo 63260-000, Brazil; andradejacquelinec@gmail.com 5 Inhamuns Region Education, Science and Technology Center, Universidade Estadual do Ceará—UECE, BR-020—Bezerra de Sousa, Tauá 63660-000, Brazil; fernanimagalhaes@yahoo.com.br 6 Center for the Development of Scientific Research, Asuncion 1255, Paraguay; mcvegagomez@gmail.com (M.C.V.G.); rolonmiriam@gmail.com (M.R.) 7 Laboratório de Investigação em Genética e Hematologia Translacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil; cathiacoronel@gmail.com (C.C.); jaimeribeirofilho@gmail.com (J.R.-F.) 8 Department of Botany, Universidade Federal de Pernambuco—UFPE, Av. Prof. Moraes Rego, 1235, Recife 50670-901, Brazil; weverton.almeida@urca.br 9 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran; asiyadatpanah@yahoo.com 10 School of Allied Health Sciences, World Union for Herbal Drug Discovery (WUHeDD) and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, Thailand; veeranoot.ni@wu.ac.th 11 CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-21T17:47:25Z
dc.date.available.fl_str_mv 2021-09-21T17:47:25Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERNANDES, Priscilla Augusta de Sousa et al. Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth. Antibiotics, v. 10, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49126
dc.identifier.issn.pt_BR.fl_str_mv 2079-6382
dc.identifier.doi.none.fl_str_mv 10.3390/antibiotics10091074
identifier_str_mv FERNANDES, Priscilla Augusta de Sousa et al. Chemical Constituents and Biological Activities of Croton heliotropiifolius Kunth. Antibiotics, v. 10, 2021.
2079-6382
10.3390/antibiotics10091074
url https://www.arca.fiocruz.br/handle/icict/49126
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49126/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49126/2/Fernandes%2c%20Priscilla%20Augusto%20de%20Sousa%20Chemical....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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