Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study

Detalhes bibliográficos
Autor(a) principal: Cardoso, Cristiane Wanderley
Data de Publicação: 2015
Outros Autores: Ribeiro, Guilherme de Sousa, Reis, Mitermayer Galvão dos, Flannery, Brendan, Reis, Joice Neves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10587
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Municipal Secretary of Health of Salvador. Salvador, BA, Brasil
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spelling Cardoso, Cristiane WanderleyRibeiro, Guilherme de SousaReis, Mitermayer Galvão dosFlannery, BrendanReis, Joice Neves2015-05-29T18:31:22Z2015-05-29T18:31:22Z2015CARDOSO, C. W. et al. Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: a case-control study. PloS One, v. 10, n.4, p. e0123734, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1058710.1371/journal.pone.0123734engPublic Library of ScienceDoença meningococicaVacinas meningococicaEpidemiaVigilânciaMasculinoFemininoControleBrasilEffectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Municipal Secretary of Health of Salvador. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia.Pan American Health Organization. Brasília, DF, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Pharmacy. Salvador, BA, BrasilDuring a citywide epidemic of serogroup C meningococcal disease in Salvador in 2010, Brazil, the state government initiated mass vaccination targeting two age groups with high attack rates: individuals aged <5 years and 10–24 years. More than 600,000 doses of meningococcal serogroup C conjugate vaccines were administered. We performed a casecontrol study to evaluate vaccine uptake, document vaccine effectiveness and identify reasons for non-vaccination. Methods and Findings Population-based surveillance identified patients with laboratory-confirmed invasive meningococcal C (MenC) disease during 2010. Information on MenC vaccination was obtained from case patients and age-matched individuals from the same neighborhoods. MenC vaccine effectiveness was estimated based on the exact odds ratios obtained by conditional logistic regression analysis. Of 51 laboratory-confirmed cases of serogroup C meningococcal disease among patients <5 and 10–24 years of age 50 were included in the study and matched with 240 controls. Overall case-fatality was 25%.MenC vaccine coverage among controls increased from 7.1%to 70.2% after initiation of the vaccination campaign. None of the 50 case patients but 70 (29.2%) of the 240 control individuals, including 59 (70.2%) of 84 matched with cases from the period afterMenC vaccination, had received at least one MenC vaccine dose. Overall effectiveness of MenC was 98%with a lower 95%exact confidence limit of 89%. Conclusions MenC vaccines administered during the meningococcal epidemic were highly effective, suggesting that rapid vaccine uptake through campaigns contributed to control of meningococcal disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10587/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALCardoso CW Effectiveness....pdfCardoso CW Effectiveness....pdfapplication/pdf221298https://www.arca.fiocruz.br/bitstream/icict/10587/2/Cardoso%20CW%20Effectiveness....pdf23e7e7443567c4da7bd23187733d960aMD52TEXTCardoso CW Effectiveness....pdf.txtCardoso CW Effectiveness....pdf.txtExtracted texttext/plain38977https://www.arca.fiocruz.br/bitstream/icict/10587/3/Cardoso%20CW%20Effectiveness....pdf.txtfc80860cdd1c19d19e90c35f60a3b5aeMD53icict/105872023-03-15 14:34:05.657oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
title Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
spellingShingle Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
Cardoso, Cristiane Wanderley
Doença meningococica
Vacinas meningococica
Epidemia
Vigilância
Masculino
Feminino
Controle
Brasil
title_short Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
title_full Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
title_fullStr Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
title_full_unstemmed Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
title_sort Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: A Case-Control Study
author Cardoso, Cristiane Wanderley
author_facet Cardoso, Cristiane Wanderley
Ribeiro, Guilherme de Sousa
Reis, Mitermayer Galvão dos
Flannery, Brendan
Reis, Joice Neves
author_role author
author2 Ribeiro, Guilherme de Sousa
Reis, Mitermayer Galvão dos
Flannery, Brendan
Reis, Joice Neves
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Cristiane Wanderley
Ribeiro, Guilherme de Sousa
Reis, Mitermayer Galvão dos
Flannery, Brendan
Reis, Joice Neves
dc.subject.other.pt_BR.fl_str_mv Doença meningococica
Vacinas meningococica
Epidemia
Vigilância
Masculino
Feminino
Controle
Brasil
topic Doença meningococica
Vacinas meningococica
Epidemia
Vigilância
Masculino
Feminino
Controle
Brasil
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Municipal Secretary of Health of Salvador. Salvador, BA, Brasil
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-05-29T18:31:22Z
dc.date.available.fl_str_mv 2015-05-29T18:31:22Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDOSO, C. W. et al. Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: a case-control study. PloS One, v. 10, n.4, p. e0123734, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10587
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0123734
identifier_str_mv CARDOSO, C. W. et al. Effectiveness of Meningococcal C Conjugate Vaccine in Salvador, Brazil: a case-control study. PloS One, v. 10, n.4, p. e0123734, 2015.
1932-6203
10.1371/journal.pone.0123734
url https://www.arca.fiocruz.br/handle/icict/10587
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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