The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23536 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil / Hospital IMIP. Departamento de Oncologia Pediátrica. Laboratório de Biologia Molecular. Recife, PE, Brazil / Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Medicina. Divisão de Imunologia Clínica. Ribeirão Preto, SP, Brazil. |
| id |
CRUZ_4fe818502ec71ab879513b7eb4f5e137 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/23536 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Lucena-Silva, N.Teixeira, M. A. G.Ramos, A. de L.de Albuquerque, R. S.Diniz, G. T. N.Mendes-Junior, C. T.Castelli, E. C.Donadi, E. A.2017-12-07T12:32:04Z2017-12-07T12:32:04Z2013LUCENA-SILVA, N. et al. The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy. Molecular Genetics & Genomic Medicine, v. 1, n. 3, p. 123–130, set. 2013.2324-9269https://www.arca.fiocruz.br/handle/icict/2353610.1002/mgg3.14engHLA-GHanseníase3 'UTR polimorfismoHansenic reação3′ UTR polymorphismHansenic reactionHLA-GleprosyhanseníasegenéticahanseníaseimunologiaRNAlepraEstudos de Casos e ControlesEstudos TransversaisBrasiljovensThe +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil / Hospital IMIP. Departamento de Oncologia Pediátrica. Laboratório de Biologia Molecular. Recife, PE, Brazil / Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Medicina. Divisão de Imunologia Clínica. Ribeirão Preto, SP, Brazil.Universidade de Pernambuco. Departamento de Dermatologia. Recife, PE, Brazil / Secretaria de Saúde de Pernambuco. Centro Integrado de Saúde Amaury de Medeiros. Recife, PE, Brazil.Hospital IMIP. Departamento de Oncologia Pediátrica. Laboratório de Biologia Molecular. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil / Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Medicina. Divisão de Imunologia Clínica. Ribeirão Preto, SP, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Métodos Quantitativos. Recife, PE, Brasil.Universidade de São Paulo. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Departamento de Química. Ribeirão Preto, SP, Brazil.Universidade Federal de Goiás. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Goiânia, GO, Brazil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Medicina. Divisão de Imunologia Clínica. Ribeirão Preto, SP, Brazil.Considering that variability in immune response genes has been associated with susceptibility to leprosy and with disease severity, leprosy presents clinicopathological variants that are highly associated with the immune response, HLA-G has a well-recognized role in the modulation of the immune response, and polymorphisms at the 3' untranslated region (UTR) of the HLA-G gene may influence HLA-G production, we studied the polymorphic sites at the 3' UTR of the HLA-G gene in leprosy and their association with disease severity. We evaluated by sequencing analysis the allele, genotype, and haplotype frequencies of the 3' UTR HLA-G polymorphic sites (14-bpINDEL/+3003C-T/+3010C-G/+3027A-C/+3035C-T/+3142C-G/+3187A-G/+3196C-G) in 146 individuals presenting reactive leprosy from a highly endemic area, and associated with bacillary load and the type of reactive leprosy. A total of 128 healthy subjects were also studied. Allele, genotype, and haplotype frequencies for the 3' UTR HLA-G polymorphisms in leprosy patients did not differ from those observed in healthy donors. The +3187A allele was responsible for protection against the development of multibacillary leprosy in a dominant model (AA + AG)/GG, OR = 0.11, P = 0.018), and the +3187A allele and +3187A-A genotype were overrepresented in type II reactive leprosy reaction. The effect of genetic factors on leprosy susceptibility may be hidden by environmental components in highly endemic areas. The HLA-G + 3187A polymorphic site, which is related to unstable mRNA production, was associated with the development of polar forms of leprosy and reactive leprosy reaction.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/23536/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALART. The 3187AG - LUCENA-SILVA.pdfART. The 3187AG - LUCENA-SILVA.pdfapplication/pdf506522https://www.arca.fiocruz.br/bitstream/icict/23536/2/ART.%20The%203187AG%20-%20LUCENA-SILVA.pdf6a520ad49a49aa9087c40cb78b0e27c2MD52TEXTART. The 3187AG - LUCENA-SILVA.pdf.txtART. The 3187AG - LUCENA-SILVA.pdf.txtExtracted texttext/plain40867https://www.arca.fiocruz.br/bitstream/icict/23536/3/ART.%20The%203187AG%20-%20LUCENA-SILVA.pdf.txt2d9b85445ba68237b82e2ee6ee17a21bMD53icict/235362018-08-15 02:08:33.334oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-08-15T05:08:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy |
| title |
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy |
| spellingShingle |
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy Lucena-Silva, N. HLA-G Hanseníase 3 'UTR polimorfismo Hansenic reação 3′ UTR polymorphism Hansenic reaction HLA-G leprosy hanseníase genética hanseníase imunologia RNA lepra Estudos de Casos e Controles Estudos Transversais Brasil jovens |
| title_short |
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy |
| title_full |
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy |
| title_fullStr |
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy |
| title_full_unstemmed |
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy |
| title_sort |
The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy |
| author |
Lucena-Silva, N. |
| author_facet |
Lucena-Silva, N. Teixeira, M. A. G. Ramos, A. de L. de Albuquerque, R. S. Diniz, G. T. N. Mendes-Junior, C. T. Castelli, E. C. Donadi, E. A. |
| author_role |
author |
| author2 |
Teixeira, M. A. G. Ramos, A. de L. de Albuquerque, R. S. Diniz, G. T. N. Mendes-Junior, C. T. Castelli, E. C. Donadi, E. A. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lucena-Silva, N. Teixeira, M. A. G. Ramos, A. de L. de Albuquerque, R. S. Diniz, G. T. N. Mendes-Junior, C. T. Castelli, E. C. Donadi, E. A. |
| dc.subject.other.pt_BR.fl_str_mv |
HLA-G Hanseníase 3 'UTR polimorfismo Hansenic reação |
| topic |
HLA-G Hanseníase 3 'UTR polimorfismo Hansenic reação 3′ UTR polymorphism Hansenic reaction HLA-G leprosy hanseníase genética hanseníase imunologia RNA lepra Estudos de Casos e Controles Estudos Transversais Brasil jovens |
| dc.subject.en.pt_BR.fl_str_mv |
3′ UTR polymorphism Hansenic reaction HLA-G leprosy |
| dc.subject.decs.pt_BR.fl_str_mv |
hanseníase genética hanseníase imunologia RNA lepra Estudos de Casos e Controles Estudos Transversais Brasil jovens |
| description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil / Hospital IMIP. Departamento de Oncologia Pediátrica. Laboratório de Biologia Molecular. Recife, PE, Brazil / Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Medicina. Divisão de Imunologia Clínica. Ribeirão Preto, SP, Brazil. |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
| dc.date.accessioned.fl_str_mv |
2017-12-07T12:32:04Z |
| dc.date.available.fl_str_mv |
2017-12-07T12:32:04Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
LUCENA-SILVA, N. et al. The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy. Molecular Genetics & Genomic Medicine, v. 1, n. 3, p. 123–130, set. 2013. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/23536 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2324-9269 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/mgg3.14 |
| identifier_str_mv |
LUCENA-SILVA, N. et al. The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy. Molecular Genetics & Genomic Medicine, v. 1, n. 3, p. 123–130, set. 2013. 2324-9269 10.1002/mgg3.14 |
| url |
https://www.arca.fiocruz.br/handle/icict/23536 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/23536/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/23536/2/ART.%20The%203187AG%20-%20LUCENA-SILVA.pdf https://www.arca.fiocruz.br/bitstream/icict/23536/3/ART.%20The%203187AG%20-%20LUCENA-SILVA.pdf.txt |
| bitstream.checksum.fl_str_mv |
447f2497af1ef5cf99b5c07f6fa18dce 6a520ad49a49aa9087c40cb78b0e27c2 2d9b85445ba68237b82e2ee6ee17a21b |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324710491029504 |