Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7799 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, Brasil |
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Felzemburgh, Ridalva Dias MartinsRibeiro, Guilherme de SousaCosta, FedericoRenato B. ReisHagan, José EdwardMelendez, Astrid X. T. ODeborah FragaFrancisco S. SantanaSharif MohrSantos, Balbino L. dosSilva, Adriano QueirozAndréia C. SantosRavines, Romy RTassinari, Wagner SCarvalho, Marilia SáReis, Mitermayer Galvão dosKo, Albert Icksang2014-06-05T14:04:26Z2014-06-05T14:04:26Z2014FELZEMBURGH, R. D. et al. Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent. PLoS Neglected Tropical Diseases,v. 8, n. 5, p. e2927, 2014.1935-272710.1371/journal.pntd.0002927https://www.arca.fiocruz.br/handle/icict/7799engPublic Library of ScienceLeptospiroseLeptospiraFavelasSaúde urbanaFatores de riscoMasculinoInfecçãoProspective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Yale University. Department of Epidemiology of Microbial Diseases. School of Public Health. New Haven, Connecticut, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Yale University. Department of Epidemiology of Microbial Diseases. School of Public Health. New Haven, Connecticut, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual de Saúde da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, Brasil / Universidade Federal Rural do Rio de Janeiro. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Escola Nacional da Saúde Pública. Rio de Janeiro, RJ, BrasilBackground: Leptospirosis has emerged as an urban health problem as slum settlements have rapidly spread worldwide and created conditions for rat-borne transmission. Prospective studies have not been performed to determine the disease burden, identify risk factors for infection and provide information needed to guide interventions in these marginalized communities. Methodology/Principal Findings: We enrolled and followed a cohort of 2,003 residents from a slum community in the city of Salvador, Brazil. Baseline and one-year serosurveys were performed to identify primary and secondary Leptospira infections, defined as respectively, seroconversion and four-fold rise in microscopic agglutination titers. We used multinomial logistic regression models to evaluate risk exposures for acquiring primary and secondary infection. A total of 51 Leptospira infections were identified among 1,585 (79%) participants who completed the one-year follow-up protocol. The crude infection rate was 37.8 per 1,000 person-years. The secondary infection rate was 2.3 times higher than that of primary infection rate (71.7 and 31.1 infections per 1,000 person-years, respectively). Male gender (OR 2.88; 95% CI 1.40– 5.91) and lower per capita household income (OR 0.54; 95% CI, 0.30–0.98 for an increase of $1 per person per day) were independent risk factors for primary infection. In contrast, the 15–34 year age group (OR 10.82, 95% CI 1.38–85.08), and proximity of residence to an open sewer (OR 0.95; 0.91–0.99 for an increase of 1 m distance) were significant risk factors for secondary infection. Conclusions/Significance: This study found that slum residents had high risk (.3% per year) for acquiring a Leptospira infection. Re-infection is a frequent event and occurs in regions of slum settlements that are in proximity to open sewers. Effective prevention of leptospirosis will therefore require interventions that address the infrastructure deficiencies that contribute to repeated exposures among slum inhabitants.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFelzemburgh RD Prospective study....pdfFelzemburgh RD Prospective study....pdfapplication/pdf263082https://www.arca.fiocruz.br/bitstream/icict/7799/1/Felzemburgh%20RD%20Prospective%20study....pdf2b20d1b45b8944b9d4ef7d31159c3c96MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7799/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTFelzemburgh RD Prospective study....pdf.txtFelzemburgh RD Prospective study....pdf.txtExtracted texttext/plain57616https://www.arca.fiocruz.br/bitstream/icict/7799/5/Felzemburgh%20RD%20Prospective%20study....pdf.txt4295bbcb12dde1c95c3e3c31ad08746fMD55THUMBNAILFelzemburgh RD Prospective study....pdf.jpgFelzemburgh RD Prospective study....pdf.jpgGenerated Thumbnailimage/jpeg2739https://www.arca.fiocruz.br/bitstream/icict/7799/4/Felzemburgh%20RD%20Prospective%20study....pdf.jpg69cf1c3ca766a38b5af679bdb946066fMD54icict/77992023-03-15 14:33:21.183oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent |
| title |
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent |
| spellingShingle |
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent Felzemburgh, Ridalva Dias Martins Leptospirose Leptospira Favelas Saúde urbana Fatores de risco Masculino Infecção |
| title_short |
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent |
| title_full |
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent |
| title_fullStr |
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent |
| title_full_unstemmed |
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent |
| title_sort |
Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent |
| author |
Felzemburgh, Ridalva Dias Martins |
| author_facet |
Felzemburgh, Ridalva Dias Martins Ribeiro, Guilherme de Sousa Costa, Federico Renato B. Reis Hagan, José Edward Melendez, Astrid X. T. O Deborah Fraga Francisco S. Santana Sharif Mohr Santos, Balbino L. dos Silva, Adriano Queiroz Andréia C. Santos Ravines, Romy R Tassinari, Wagner S Carvalho, Marilia Sá Reis, Mitermayer Galvão dos Ko, Albert Icksang |
| author_role |
author |
| author2 |
Ribeiro, Guilherme de Sousa Costa, Federico Renato B. Reis Hagan, José Edward Melendez, Astrid X. T. O Deborah Fraga Francisco S. Santana Sharif Mohr Santos, Balbino L. dos Silva, Adriano Queiroz Andréia C. Santos Ravines, Romy R Tassinari, Wagner S Carvalho, Marilia Sá Reis, Mitermayer Galvão dos Ko, Albert Icksang |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Felzemburgh, Ridalva Dias Martins Ribeiro, Guilherme de Sousa Costa, Federico Renato B. Reis Hagan, José Edward Melendez, Astrid X. T. O Deborah Fraga Francisco S. Santana Sharif Mohr Santos, Balbino L. dos Silva, Adriano Queiroz Andréia C. Santos Ravines, Romy R Tassinari, Wagner S Carvalho, Marilia Sá Reis, Mitermayer Galvão dos Ko, Albert Icksang |
| dc.subject.other.pt_BR.fl_str_mv |
Leptospirose Leptospira Favelas Saúde urbana Fatores de risco Masculino Infecção |
| topic |
Leptospirose Leptospira Favelas Saúde urbana Fatores de risco Masculino Infecção |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, Brasil |
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2014 |
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2014-06-05T14:04:26Z |
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2014-06-05T14:04:26Z |
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2014 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FELZEMBURGH, R. D. et al. Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent. PLoS Neglected Tropical Diseases,v. 8, n. 5, p. e2927, 2014. |
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https://www.arca.fiocruz.br/handle/icict/7799 |
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1935-2727 10.1371/journal.pntd.0002927 |
| identifier_str_mv |
FELZEMBURGH, R. D. et al. Prospective study of leptospirosis transmission in an urban slum community: role of poor environment in repeated exposures to the leptospira agent. PLoS Neglected Tropical Diseases,v. 8, n. 5, p. e2927, 2014. 1935-2727 10.1371/journal.pntd.0002927 |
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