Lectin-induced nitric oxide production

Bibliographic Details
Main Author: Andrade, Jó Luis
Publication Date: 1999
Other Authors: Arruda, Sérgio Marcos, Bessa, Theolis Costa Barbosa, Paim, Luciana, Ramos, Márcio Viana, Cavada, Benildo Sousa, Barral Netto, Manoel
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/5650
Summary: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Jó LuisArruda, Sérgio MarcosBessa, Theolis Costa BarbosaPaim, LucianaRamos, Márcio VianaCavada, Benildo SousaBarral Netto, Manoel2012-10-05T17:40:00Z2012-10-05T17:40:00Z1999ANDRADE, J.L. et al. Lectin-induced nitric oxide production. Cellular Immunology, v. 194, n. 1, p. 98-102, may.1999.0008-8749https://www.arca.fiocruz.br/handle/icict/5650engLectin-induced nitric oxide productioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Ceará. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilConsidering that nitric oxide (NO) may be involved in anti-tumoral and anti-parasite lectin effects, in this report we investigated whether lectin induces NO production. Lectins from Canavalia brasiliensis, Dioclea grandiflora, Pisum arvense (PAA), and concanavalin A induced murine peritoneal cells to produce NO in vitro. PAA induced similar levels to that obtained with lipopolysaccharide plus interferon-gamma. NO production by adherent cells was significantly lower than that of unfractionated cells, suggesting a combination of lectin stimuli directly on macrophages and via lymphocyte stimulation. Ex vivo experiments showed that cells stimulated in vivo could maintain NO production in vitro without further stimuli. NO synthesis blockage in vivo can significantly increase cell numbers in draining lymph nodes after lectin injection compared to unblocked controls, suggesting an in vivo association of lectin stimuli and NO production. Taken together these data show that lectins can induce NO production both in vitro and in vivo.Nitric OxideAdherent cellsPeritoneal cellsMacrophagesImmunologyCanavalia BrasiliensisCanavalia EnsiformisConcanavalin AConADioclea GrandifloraPisum ArvenseLectinas/imunologiaÓxido Nítrico/biossínteseLectinas de PlantasAnimaisCélulas CultivadasConcanavalina A/imunologiaConcanavalina A/farmacologiaFemininoLectinas/farmacologiaCamundongosCamundongos Endogâmicos BALB CPeritônio/citologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade JL Lectin-induced nitric ....pdfAndrade JL Lectin-induced nitric ....pdfapplication/pdf71074https://www.arca.fiocruz.br/bitstream/icict/5650/1/Andrade%20JL%20Lectin-induced%20nitric%20....pdff7de8fb9030ae4bcda9517881955be83MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5650/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade JL Lectin-induced nitric ....pdf.txtAndrade JL Lectin-induced nitric ....pdf.txtExtracted texttext/plain25336https://www.arca.fiocruz.br/bitstream/icict/5650/5/Andrade%20JL%20Lectin-induced%20nitric%20....pdf.txtfc3e78e0dcfa0d7890d7e59880bdb652MD55THUMBNAILAndrade JL Lectin-induced nitric ....pdf.jpgAndrade JL Lectin-induced nitric ....pdf.jpgGenerated Thumbnailimage/jpeg2489https://www.arca.fiocruz.br/bitstream/icict/5650/4/Andrade%20JL%20Lectin-induced%20nitric%20....pdf.jpg468961cb1109b499fbaf8e10a6e97afaMD54icict/56502023-03-15 14:33:09.865oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Lectin-induced nitric oxide production
title Lectin-induced nitric oxide production
spellingShingle Lectin-induced nitric oxide production
Andrade, Jó Luis
Nitric Oxide
Adherent cells
Peritoneal cells
Macrophages
Immunology
Canavalia Brasiliensis
Canavalia Ensiformis
Concanavalin A
ConA
Dioclea Grandiflora
Pisum Arvense
Lectinas/imunologia
Óxido Nítrico/biossíntese
Lectinas de Plantas
Animais
Células Cultivadas
Concanavalina A/imunologia
Concanavalina A/farmacologia
Feminino
Lectinas/farmacologia
Camundongos
Camundongos Endogâmicos BALB C
Peritônio/citologia
title_short Lectin-induced nitric oxide production
title_full Lectin-induced nitric oxide production
title_fullStr Lectin-induced nitric oxide production
title_full_unstemmed Lectin-induced nitric oxide production
title_sort Lectin-induced nitric oxide production
author Andrade, Jó Luis
author_facet Andrade, Jó Luis
Arruda, Sérgio Marcos
Bessa, Theolis Costa Barbosa
Paim, Luciana
Ramos, Márcio Viana
Cavada, Benildo Sousa
Barral Netto, Manoel
author_role author
author2 Arruda, Sérgio Marcos
Bessa, Theolis Costa Barbosa
Paim, Luciana
Ramos, Márcio Viana
Cavada, Benildo Sousa
Barral Netto, Manoel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Jó Luis
Arruda, Sérgio Marcos
Bessa, Theolis Costa Barbosa
Paim, Luciana
Ramos, Márcio Viana
Cavada, Benildo Sousa
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Nitric Oxide
Adherent cells
Peritoneal cells
Macrophages
Immunology
Canavalia Brasiliensis
Canavalia Ensiformis
Concanavalin A
ConA
Dioclea Grandiflora
Pisum Arvense
topic Nitric Oxide
Adherent cells
Peritoneal cells
Macrophages
Immunology
Canavalia Brasiliensis
Canavalia Ensiformis
Concanavalin A
ConA
Dioclea Grandiflora
Pisum Arvense
Lectinas/imunologia
Óxido Nítrico/biossíntese
Lectinas de Plantas
Animais
Células Cultivadas
Concanavalina A/imunologia
Concanavalina A/farmacologia
Feminino
Lectinas/farmacologia
Camundongos
Camundongos Endogâmicos BALB C
Peritônio/citologia
dc.subject.decs.pt_BR.fl_str_mv Lectinas/imunologia
Óxido Nítrico/biossíntese
Lectinas de Plantas
Animais
Células Cultivadas
Concanavalina A/imunologia
Concanavalina A/farmacologia
Feminino
Lectinas/farmacologia
Camundongos
Camundongos Endogâmicos BALB C
Peritônio/citologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2012-10-05T17:40:00Z
dc.date.available.fl_str_mv 2012-10-05T17:40:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, J.L. et al. Lectin-induced nitric oxide production. Cellular Immunology, v. 194, n. 1, p. 98-102, may.1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5650
dc.identifier.issn.none.fl_str_mv 0008-8749
identifier_str_mv ANDRADE, J.L. et al. Lectin-induced nitric oxide production. Cellular Immunology, v. 194, n. 1, p. 98-102, may.1999.
0008-8749
url https://www.arca.fiocruz.br/handle/icict/5650
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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