Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26119 |
Resumo: | PAPES V/FIOCRUZ, CNPq (to SMLM) |
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Morais, Clarice Neuenschwander Lins deCarvalho, Bruno de MeloMelo, Wlademir Gomes deMelo, Fábio Lopes deLopes, Edmundo Pessoa de AlmeidaDomingues, Ana Lúcia CoutinhoJucá, NormaMartins, João Roberto MacielDiniz, George Tadeu NunesMontenegro, Silvia Maria Lucena2018-04-26T12:03:44Z2018-04-26T12:03:44Z2010MORAIS, C. N. L. DE et al. Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 460–466, jul. 2010.1678-8060https://www.arca.fiocruz.br/handle/icict/2611910.1590/S0074-02762010000400018PAPES V/FIOCRUZ, CNPq (to SMLM)Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Liver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-gamma, TNF-alpha and TGF-beta, platelets, bilirubins (Bil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total proteins, gamma-glutamil transferase (gamma-GT) and alkaline phosphatase (AP), that could be used to predict the severity of hepatic fibrosis in schistosomiasis and hepatitis C (HC) as isolated diseases or co-infections. The following patient groups were selected: HC (n = 39), HC/hepatosplenic schistosomiasis (HSS) (n = 19), HSS (n = 22) and a control group (n = 13). ANOVA and ROC curves were used for statistical analysis. P < 0.05 was considered significant. With HC patients we showed that TNF-alpha (p = 0.020) and AP (p = 0.005) could differentiate mild and severe fibrosis. With regard to necroinflammatory activity, AST (p = 0.002), gamma-GT (p = 0.034) and AP (p = 0.001) were the best markers to differentiate mild and severe activity. In HC + HSS patients, total Bil (p = 0.008) was capable of differentiating between mild and severe fibrosis. In conclusion, our study was able to suggest biological markers that are non-invasive candidates to evaluate fibrosis and necroinflammatory activity in HC and HC + HSS.engMarcadores biológicosFibrose hepáticaHCEsquistossomoseBiological markersHepatic fibrosisHCSchistosomiasisAdolescenteAdultoAnálise de variaçãoIdosoBiomarcadores / sangueEstudos de caso-controleHepatite C / sangueHepatite C / complicaçõesHepatite C / patologiaHumanosCirrose Hepática / sangueCirrose Hepática / complicaçõesCirrose hepática / patologiaHepatopatias Parasitárias / sangueHepatopatias Parasitárias / complicaçõesHepatopatias Parasitárias / patologiaMeia idadeNecrose / patologiaCurva ROCEsquistossomose / sangueEsquistossomose / complicaçõesEsquistossomose / patologiaÍndice de Gravidade da DoençaDoenças esplênicas / sangueDoenças esplênicas / complicaçõesDoenças esplênicas / patologiaAdulto jovemCorrelation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis 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| dc.title.pt_BR.fl_str_mv |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| spellingShingle |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients Morais, Clarice Neuenschwander Lins de Marcadores biológicos Fibrose hepática HC Esquistossomose Biological markers Hepatic fibrosis HC Schistosomiasis Adolescente Adulto Análise de variação Idoso Biomarcadores / sangue Estudos de caso-controle Hepatite C / sangue Hepatite C / complicações Hepatite C / patologia Humanos Cirrose Hepática / sangue Cirrose Hepática / complicações Cirrose hepática / patologia Hepatopatias Parasitárias / sangue Hepatopatias Parasitárias / complicações Hepatopatias Parasitárias / patologia Meia idade Necrose / patologia Curva ROC Esquistossomose / sangue Esquistossomose / complicações Esquistossomose / patologia Índice de Gravidade da Doença Doenças esplênicas / sangue Doenças esplênicas / complicações Doenças esplênicas / patologia Adulto jovem |
| title_short |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_full |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_fullStr |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_full_unstemmed |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| title_sort |
Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients |
| author |
Morais, Clarice Neuenschwander Lins de |
| author_facet |
Morais, Clarice Neuenschwander Lins de Carvalho, Bruno de Melo Melo, Wlademir Gomes de Melo, Fábio Lopes de Lopes, Edmundo Pessoa de Almeida Domingues, Ana Lúcia Coutinho Jucá, Norma Martins, João Roberto Maciel Diniz, George Tadeu Nunes Montenegro, Silvia Maria Lucena |
| author_role |
author |
| author2 |
Carvalho, Bruno de Melo Melo, Wlademir Gomes de Melo, Fábio Lopes de Lopes, Edmundo Pessoa de Almeida Domingues, Ana Lúcia Coutinho Jucá, Norma Martins, João Roberto Maciel Diniz, George Tadeu Nunes Montenegro, Silvia Maria Lucena |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Morais, Clarice Neuenschwander Lins de Carvalho, Bruno de Melo Melo, Wlademir Gomes de Melo, Fábio Lopes de Lopes, Edmundo Pessoa de Almeida Domingues, Ana Lúcia Coutinho Jucá, Norma Martins, João Roberto Maciel Diniz, George Tadeu Nunes Montenegro, Silvia Maria Lucena |
| dc.subject.other.pt_BR.fl_str_mv |
Marcadores biológicos Fibrose hepática HC Esquistossomose |
| topic |
Marcadores biológicos Fibrose hepática HC Esquistossomose Biological markers Hepatic fibrosis HC Schistosomiasis Adolescente Adulto Análise de variação Idoso Biomarcadores / sangue Estudos de caso-controle Hepatite C / sangue Hepatite C / complicações Hepatite C / patologia Humanos Cirrose Hepática / sangue Cirrose Hepática / complicações Cirrose hepática / patologia Hepatopatias Parasitárias / sangue Hepatopatias Parasitárias / complicações Hepatopatias Parasitárias / patologia Meia idade Necrose / patologia Curva ROC Esquistossomose / sangue Esquistossomose / complicações Esquistossomose / patologia Índice de Gravidade da Doença Doenças esplênicas / sangue Doenças esplênicas / complicações Doenças esplênicas / patologia Adulto jovem |
| dc.subject.en.pt_BR.fl_str_mv |
Biological markers Hepatic fibrosis HC Schistosomiasis |
| dc.subject.decs.pt_BR.fl_str_mv |
Adolescente Adulto Análise de variação Idoso Biomarcadores / sangue Estudos de caso-controle Hepatite C / sangue Hepatite C / complicações Hepatite C / patologia Humanos Cirrose Hepática / sangue Cirrose Hepática / complicações Cirrose hepática / patologia Hepatopatias Parasitárias / sangue Hepatopatias Parasitárias / complicações Hepatopatias Parasitárias / patologia Meia idade Necrose / patologia Curva ROC Esquistossomose / sangue Esquistossomose / complicações Esquistossomose / patologia Índice de Gravidade da Doença Doenças esplênicas / sangue Doenças esplênicas / complicações Doenças esplênicas / patologia Adulto jovem |
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2010 |
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2018-04-26T12:03:44Z |
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2018-04-26T12:03:44Z |
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MORAIS, C. N. L. DE et al. Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 460–466, jul. 2010. |
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https://www.arca.fiocruz.br/handle/icict/26119 |
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1678-8060 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762010000400018 |
| identifier_str_mv |
MORAIS, C. N. L. DE et al. Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 460–466, jul. 2010. 1678-8060 10.1590/S0074-02762010000400018 |
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https://www.arca.fiocruz.br/handle/icict/26119 |
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eng |
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