Chagas disease: what is known and what is needed – A background article

Detalhes bibliográficos
Autor(a) principal: Coura, José Rodrigues
Data de Publicação: 2007
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44589
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
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spelling Coura, José Rodrigues2020-11-23T14:40:02Z2020-11-23T14:40:02Z2007COURA, José Rodrigues. Chagas disease: what is known and what is needed – A background article. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, Suppl. 1, p. 113-122, 2007.0074-0276https://www.arca.fiocruz.br/handle/icict/4458910.1590/S0074-027620070009000181678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Doença de ChagasTrypanosoma cruziTriatomíneosPatogêneseFormas cinéticasMorbidade-MortalidadeChagas DiseaseTrypanosoma cruziTriatominesPathogenesisCinical formsmorbidity-mortalityChagas disease: what is known and what is needed – A background articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Chagas disease began millions of years ago as an enzootic disease of wild animals and started to be transmitted to man accidentally in the form of an anthropozoonosis when man invaded wild ecotopes. Endemic Chagas disease became established as a zoonosis over the last 200-300 years through forest clearance for agriculture and livestock rearing and adaptation of triatomines to domestic environments and to man and domestic animals as a food source. It is estimated that 15 to 16 million people are infected with Trypanosoma cruzi in Latin America and 75 to 90 million people are exposed to infection. When T. cruzi is transmitted to man through the feces of triatomines, at bite sites or in mucosa, through blood transfusion or orally through contaminated food, it invades the bloodstream and lymphatic system and becomes established in the muscle and cardiac tissue, the digestive system and phagocytic cells. This causes inflammatory lesions and immune responses, particularly mediated by CD4+, CD8+, interleukin-2 (IL) and IL-4, with cell and neuron destruction and fibrosis, and leads to blockage of the cardiac conduction system, arrhythmia, cardiac insufficiency, aperistalsis, and dilatation of hollow viscera, particularly the esophagus and colon. T. cruzi may also be transmitted from mother to child across the placenta and through the birth canal, thus causing abortion, prematurity, and organic lesions in the fetus. In immunosuppressed individuals, T. cruzi infection may become reactivated such that it spreads as a severe disease causing diffuse myocarditis and lesions of the central nervous system. Chagas disease is characterized by an acute phase with or without symptoms, and with entry point signs (inoculation chagoma or Romaña’s sign), fever, adenomegaly, hepatosplenomegaly, and evident parasitemia, and an indeterminate chronic phase (asymptomatic, with normal results from electrocardiogram and xray of the heart, esophagus, and colon) or with a cardiac, digestive or cardiac-digestive form. There is great regional variation in the morbidity due to Chagas disease, and severe cardiac or digestive forms may occur in 10 to 50% of the cases, or the indeterminate form in the other asymptomatic cases, but with positive serology. Several acute cases have been reported from Amazon region most of them by T. cruzi I, Z3, and a hybrid ZI/Z3. We conclude this article presenting the ten top Chagas disease needs for the near future.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44589/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseR_Coura_IOC_2007.pdfJoseR_Coura_IOC_2007.pdfapplication/pdf1853785https://www.arca.fiocruz.br/bitstream/icict/44589/2/JoseR_Coura_IOC_2007.pdf417b8bf9f0a2d18c7ab850050eb60752MD52TEXTJoseR_Coura_IOC_2007.pdf.txtJoseR_Coura_IOC_2007.pdf.txtExtracted texttext/plain43149https://www.arca.fiocruz.br/bitstream/icict/44589/3/JoseR_Coura_IOC_2007.pdf.txt47dc8e822e134d86fbf2613131ff4b99MD53icict/445892020-11-24 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dc.title.pt_BR.fl_str_mv Chagas disease: what is known and what is needed – A background article
title Chagas disease: what is known and what is needed – A background article
spellingShingle Chagas disease: what is known and what is needed – A background article
Coura, José Rodrigues
Doença de Chagas
Trypanosoma cruzi
Triatomíneos
Patogênese
Formas cinéticas
Morbidade-Mortalidade
Chagas Disease
Trypanosoma cruzi
Triatomines
Pathogenesis
Cinical forms
morbidity-mortality
title_short Chagas disease: what is known and what is needed – A background article
title_full Chagas disease: what is known and what is needed – A background article
title_fullStr Chagas disease: what is known and what is needed – A background article
title_full_unstemmed Chagas disease: what is known and what is needed – A background article
title_sort Chagas disease: what is known and what is needed – A background article
author Coura, José Rodrigues
author_facet Coura, José Rodrigues
author_role author
dc.contributor.author.fl_str_mv Coura, José Rodrigues
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Trypanosoma cruzi
Triatomíneos
Patogênese
Formas cinéticas
Morbidade-Mortalidade
topic Doença de Chagas
Trypanosoma cruzi
Triatomíneos
Patogênese
Formas cinéticas
Morbidade-Mortalidade
Chagas Disease
Trypanosoma cruzi
Triatomines
Pathogenesis
Cinical forms
morbidity-mortality
dc.subject.en.pt_BR.fl_str_mv Chagas Disease
Trypanosoma cruzi
Triatomines
Pathogenesis
Cinical forms
morbidity-mortality
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2020-11-23T14:40:02Z
dc.date.available.fl_str_mv 2020-11-23T14:40:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COURA, José Rodrigues. Chagas disease: what is known and what is needed – A background article. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, Suppl. 1, p. 113-122, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44589
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762007000900018
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv COURA, José Rodrigues. Chagas disease: what is known and what is needed – A background article. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, Suppl. 1, p. 113-122, 2007.
0074-0276
10.1590/S0074-02762007000900018
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44589
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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