Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/34926 |
Resumo: | 2020-01-01 |
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Corrêa, Jôice DiasFernandes, Gabriel da RochaCalderaro, Débora CerqueiraMendonça, Santuza Maria SouzaSilva, Janine MayraAlbiero, Mayra LainoCunha, Fernando Q.Xiao, E.Ferreira, Gilda AparecidaTeixeira, Antônio LúcioMukherjee, ChiranjitLeys, Eugene J.Silva, Tarcília AparecidaGraves, Dana T.2019-08-21T14:15:41Z2019-08-21T14:15:41Z2019CORRÊA, Jôice Dias et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep., v. 9, n. 1, 8379, 20192045-2322https://www.arca.fiocruz.br/handle/icict/3492610.1038/s41598-019-44674-6engNature Publishing GroupOral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG BrazilUniversidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG BrazilUniversidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG BrazilUniversidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG BrazilUniversidade de Campinas. Faculdade de Odontologia. Piracicaba, SP BrazilUniversidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP BrazilPenn Dental School. University of Pennsylvania. Philadelphia, PA USAUniversidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG BrazilUniversidade Federal de Minas Gerais. Hospital Universitário. Belo Horizonte, MG BrazilThe Ohio State University. College of Dentistry. Columbus, OH USAThe Ohio State University. College of Dentistry. Columbus, OH USAUniversidade Federal de Minas Gerais. Faculdade de Odontologia. Belo Horizonte, MG BrazilPenn Dental School. University of Pennsylvania. Philadelphia, PA USARheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that periodontitis is associated with increased RA severity and treatment of periodontitis can improve the symptoms of RA. The possible mechanism for this association is through dysbiosis of the oral microbiota triggered by RA-induced systemic inflammation. We examined the RA status of subjects by measuring the number of tender and swollen joints, anti-citrullinated protein antibody and rheumatoid factor. Periodontal disease status and salivary cytokine levels were measured, and dental plaque analyzed by 16S rRNA high throughput sequencing. RA patients had a higher bacterial load, a more diverse microbiota, an increase in bacterial species associated with periodontal disease, more clinical attachment loss, and increased production of inflammatory mediators including IL-17, IL-2, TNF, and IFN-γ. Furthermore, changes in the oral microbiota were linked to worse RA conditions. Our study provides new insights into the bi-directional relationship between periodontitis and RA and suggest that monitoring the periodontal health of RA patients is particularly important.Rheumatoid arthritisMicrobiologyPeriodonticsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/34926/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALOral microbial dysbiosis linked.pdfOral microbial dysbiosis linked.pdfapplication/pdf1047172https://www.arca.fiocruz.br/bitstream/icict/34926/2/Oral%20microbial%20dysbiosis%20linked.pdfc5840c88425350c4bb2be06a733497f1MD52TEXTOral microbial dysbiosis linked.pdf.txtOral microbial dysbiosis linked.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients |
| title |
Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients |
| spellingShingle |
Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients Corrêa, Jôice Dias Rheumatoid arthritis Microbiology Periodontics |
| title_short |
Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients |
| title_full |
Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients |
| title_fullStr |
Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients |
| title_full_unstemmed |
Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients |
| title_sort |
Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients |
| author |
Corrêa, Jôice Dias |
| author_facet |
Corrêa, Jôice Dias Fernandes, Gabriel da Rocha Calderaro, Débora Cerqueira Mendonça, Santuza Maria Souza Silva, Janine Mayra Albiero, Mayra Laino Cunha, Fernando Q. Xiao, E. Ferreira, Gilda Aparecida Teixeira, Antônio Lúcio Mukherjee, Chiranjit Leys, Eugene J. Silva, Tarcília Aparecida Graves, Dana T. |
| author_role |
author |
| author2 |
Fernandes, Gabriel da Rocha Calderaro, Débora Cerqueira Mendonça, Santuza Maria Souza Silva, Janine Mayra Albiero, Mayra Laino Cunha, Fernando Q. Xiao, E. Ferreira, Gilda Aparecida Teixeira, Antônio Lúcio Mukherjee, Chiranjit Leys, Eugene J. Silva, Tarcília Aparecida Graves, Dana T. |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Corrêa, Jôice Dias Fernandes, Gabriel da Rocha Calderaro, Débora Cerqueira Mendonça, Santuza Maria Souza Silva, Janine Mayra Albiero, Mayra Laino Cunha, Fernando Q. Xiao, E. Ferreira, Gilda Aparecida Teixeira, Antônio Lúcio Mukherjee, Chiranjit Leys, Eugene J. Silva, Tarcília Aparecida Graves, Dana T. |
| dc.subject.en.pt_BR.fl_str_mv |
Rheumatoid arthritis Microbiology Periodontics |
| topic |
Rheumatoid arthritis Microbiology Periodontics |
| description |
2020-01-01 |
| publishDate |
2019 |
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2019-08-21T14:15:41Z |
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2019-08-21T14:15:41Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CORRÊA, Jôice Dias et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep., v. 9, n. 1, 8379, 2019 |
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https://www.arca.fiocruz.br/handle/icict/34926 |
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2045-2322 |
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10.1038/s41598-019-44674-6 |
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CORRÊA, Jôice Dias et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep., v. 9, n. 1, 8379, 2019 2045-2322 10.1038/s41598-019-44674-6 |
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Nature Publishing Group |
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Nature Publishing Group |
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