NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis

Bibliographic Details
Main Author: Reis, Eliana Almeida Gomes
Publication Date: 2009
Other Authors: Athanazio, Daniel Abensur, Lima, Isabella, Silva, Natália Oliveira e, Andrade, Jorge Clarêncio de Souza, Jesus, Ronden N, Barbosa, Lúcio Macedo, Reis, Mitermayer Galvão dos, Santiago, Mittermayer Barreto
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/7585
Summary: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Reis, Eliana Almeida GomesAthanazio, Daniel AbensurLima, IsabellaSilva, Natália Oliveira eAndrade, Jorge Clarêncio de SouzaJesus, Ronden NBarbosa, Lúcio MacedoReis, Mitermayer Galvão dosSantiago, Mittermayer Barreto2014-05-06T14:11:06Z2014-05-06T14:11:06Z2009REIS, E. A. G. et al. NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis. Rheumatology International, v. 29, n. 4, p. 469-475, 2009.1437-160X10.1007/s00296-008-0719-0https://www.arca.fiocruz.br/handle/icict/7585engSpringer InternationalNK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilServiço de Reumatologia do Hospital Santa Izabel. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública (Medical School). Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública (Medical School). Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública (Medical School). Salvador, BA, BrasilBiomarkers of clinical response to rituximab (RTX) therapy and early predictors of outcome are still under investigation. We report a flow cytometric immunophenotyping analysis from peripheral blood leukocyte subpopulations of two patients with systemic lupus erythematosus (SLE) associated thrombocytopenia and one patient with rheumatoid arthritis (RA), before and after 6 weeks of treatment with RTX. Our results show a reduced population of CD19(+) expressing cells (B cells) after RTX treatment in all three patients. Increased frequency of peripheral regulatory CD4(+)CD25(high) T cell subset and the CD3(-)CD16(-)CD56(bright) NK cell subset after RTX therapy were also observed in all patients, the latter being more pronounced in the SLE patient with sustained clinical response. In addition, an increased population of NKT cell subsets was observed in the patients with clinical response. This is the first evaluation of NK and NKT cells as biomarkers of clinical response after rituximab therapy in rheumatic diseasesSystemic lupus erythematosusRheumatoid arthritisNatural killer cellsRituximabAnticorpos Monoclonais/uso terapêuticoAntirreumáticos/uso terapêuticoArtrite Reumatoide/quimioterapiaLúpus Eritematoso Sistêmico/quimioterapiaCélulas T Matadoras Naturais/imunologiaAdultoAnticorpos Monoclonais/imunologiaAnticorpos Monoclonais MurinosAntirreumáticos/imunologiaArtrite Reumatoide/sangueArtrite Reumatoide/imunologiaFemininoCitometria de FluxoHumanosImunofenotipagemLúpus Eritematoso Sistêmico/sangueLúpus Eritematoso Sistêmico/imunologiaMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALReis EAG NK and NKT cells....pdfReis EAG NK and NKT cells....pdfapplication/pdf314730https://www.arca.fiocruz.br/bitstream/icict/7585/1/Reis%20EAG%20NK%20and%20NKT%20cells....pdf1e4221568d038d7891f8baf8c9889b80MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7585/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTReis EAG NK and NKT cells....pdf.txtReis EAG NK and NKT cells....pdf.txtExtracted texttext/plain26118https://www.arca.fiocruz.br/bitstream/icict/7585/5/Reis%20EAG%20NK%20and%20NKT%20cells....pdf.txte888dda5b5594594eeae4d2d62bb4687MD55THUMBNAILReis EAG NK and NKT cells....pdf.jpgReis EAG NK and NKT cells....pdf.jpgGenerated Thumbnailimage/jpeg2316https://www.arca.fiocruz.br/bitstream/icict/7585/4/Reis%20EAG%20NK%20and%20NKT%20cells....pdf.jpgdd2cd0b7415ac579650955524604bb63MD54icict/75852023-03-15 14:33:18.551oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
spellingShingle NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
Reis, Eliana Almeida Gomes
Systemic lupus erythematosus
Rheumatoid arthritis
Natural killer cells
Rituximab
Anticorpos Monoclonais/uso terapêutico
Antirreumáticos/uso terapêutico
Artrite Reumatoide/quimioterapia
Lúpus Eritematoso Sistêmico/quimioterapia
Células T Matadoras Naturais/imunologia
Adulto
Anticorpos Monoclonais/imunologia
Anticorpos Monoclonais Murinos
Antirreumáticos/imunologia
Artrite Reumatoide/sangue
Artrite Reumatoide/imunologia
Feminino
Citometria de Fluxo
Humanos
Imunofenotipagem
Lúpus Eritematoso Sistêmico/sangue
Lúpus Eritematoso Sistêmico/imunologia
Meia-Idade
title_short NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title_full NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title_fullStr NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title_full_unstemmed NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
title_sort NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
author Reis, Eliana Almeida Gomes
author_facet Reis, Eliana Almeida Gomes
Athanazio, Daniel Abensur
Lima, Isabella
Silva, Natália Oliveira e
Andrade, Jorge Clarêncio de Souza
Jesus, Ronden N
Barbosa, Lúcio Macedo
Reis, Mitermayer Galvão dos
Santiago, Mittermayer Barreto
author_role author
author2 Athanazio, Daniel Abensur
Lima, Isabella
Silva, Natália Oliveira e
Andrade, Jorge Clarêncio de Souza
Jesus, Ronden N
Barbosa, Lúcio Macedo
Reis, Mitermayer Galvão dos
Santiago, Mittermayer Barreto
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Eliana Almeida Gomes
Athanazio, Daniel Abensur
Lima, Isabella
Silva, Natália Oliveira e
Andrade, Jorge Clarêncio de Souza
Jesus, Ronden N
Barbosa, Lúcio Macedo
Reis, Mitermayer Galvão dos
Santiago, Mittermayer Barreto
dc.subject.en.pt_BR.fl_str_mv Systemic lupus erythematosus
Rheumatoid arthritis
Natural killer cells
Rituximab
topic Systemic lupus erythematosus
Rheumatoid arthritis
Natural killer cells
Rituximab
Anticorpos Monoclonais/uso terapêutico
Antirreumáticos/uso terapêutico
Artrite Reumatoide/quimioterapia
Lúpus Eritematoso Sistêmico/quimioterapia
Células T Matadoras Naturais/imunologia
Adulto
Anticorpos Monoclonais/imunologia
Anticorpos Monoclonais Murinos
Antirreumáticos/imunologia
Artrite Reumatoide/sangue
Artrite Reumatoide/imunologia
Feminino
Citometria de Fluxo
Humanos
Imunofenotipagem
Lúpus Eritematoso Sistêmico/sangue
Lúpus Eritematoso Sistêmico/imunologia
Meia-Idade
dc.subject.decs.pt_BR.fl_str_mv Anticorpos Monoclonais/uso terapêutico
Antirreumáticos/uso terapêutico
Artrite Reumatoide/quimioterapia
Lúpus Eritematoso Sistêmico/quimioterapia
Células T Matadoras Naturais/imunologia
Adulto
Anticorpos Monoclonais/imunologia
Anticorpos Monoclonais Murinos
Antirreumáticos/imunologia
Artrite Reumatoide/sangue
Artrite Reumatoide/imunologia
Feminino
Citometria de Fluxo
Humanos
Imunofenotipagem
Lúpus Eritematoso Sistêmico/sangue
Lúpus Eritematoso Sistêmico/imunologia
Meia-Idade
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2014-05-06T14:11:06Z
dc.date.available.fl_str_mv 2014-05-06T14:11:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, E. A. G. et al. NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis. Rheumatology International, v. 29, n. 4, p. 469-475, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7585
dc.identifier.issn.none.fl_str_mv 1437-160X
10.1007/s00296-008-0719-0
identifier_str_mv REIS, E. A. G. et al. NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis. Rheumatology International, v. 29, n. 4, p. 469-475, 2009.
1437-160X
10.1007/s00296-008-0719-0
url https://www.arca.fiocruz.br/handle/icict/7585
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer International
publisher.none.fl_str_mv Springer International
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7585/1/Reis%20EAG%20NK%20and%20NKT%20cells....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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