Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51169 |
Resumo: | Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA |
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Gouveia, Mateus HenriqueBentley, Amy R.Leonard, HamptonMeeks, Karlijn A. C.Ekoru, KennethChen, GuanjieNalls, Michael A.Simonsick, Eleanor M.Santos, Eduardo TarazonaCosta, Maria Fernanda Furtado LimaAdeyemo, AdebowaleShriner, DanielRotimi, Charles N.2022-02-14T13:37:36Z2022-02-14T13:37:36Z2021GOUVEIA, Mateus Henrique et al. Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits. Sci Rep., v. 11, 4075, 2021. https://doi.org/10.1038/s41598-021-83450-32045-2322https://www.arca.fiocruz.br/handle/icict/51169engNatureTrans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traitsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCenter for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USACenter for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USALaboratory of Neurogenetics. National Institute on Aging. National Institutes of Health. Bethesda, MD, USACenter for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USACenter for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USACenter for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USALaboratory of Neurogenetics. National Institute on Aging. National Institutes of Health. Bethesda, MD, USALongitudinal Studies Section. Translational Gerontology Branch. National Institute on Aging. Baltimore, MD, USAUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, BrazilCenter for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USACenter for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USACenter for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USAGenome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal and four on cross-sectional BP traits. Most of the novel loci were ethnic- or study-specific, with the majority identified in African Americans (AA). Four of these discoveries showed additional evidence of association in independent datasets, including an intergenic variant (rs4060030, p=7.3x10(-9)) with reported regulatory function. We observed a high correlation between the meta-analysis results for baseline and longitudinal average BP (rho=0.48). BP trajectory results were more correlated with those of average BP (rho=0.35) than baseline BP(rho=0.18). Heritability estimates trended higher for longitudinal traits than for cross-sectional traits, providing evidence for different genetic architectures. Furthermore, the longitudinal data identified up to 20% more BP known associations than did cross-sectional data. Our analyses of longitudinal BP data in diverse ethnic groups identified novel BP loci associated with BP trajectory, indicating a need for further longitudinal GWAS on BP and other age-related traits.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51169/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALTrans‑ethnic meta‑analysis.pdfTrans‑ethnic meta‑analysis.pdfapplication/pdf7227426https://www.arca.fiocruz.br/bitstream/icict/51169/2/Trans%e2%80%91ethnic%20meta%e2%80%91analysis.pdfec9b629e15f0f7cb024a25534a78102eMD52icict/511692022-02-14 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| dc.title.pt_BR.fl_str_mv |
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits |
| title |
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits |
| spellingShingle |
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits Gouveia, Mateus Henrique |
| title_short |
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits |
| title_full |
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits |
| title_fullStr |
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits |
| title_full_unstemmed |
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits |
| title_sort |
Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits |
| author |
Gouveia, Mateus Henrique |
| author_facet |
Gouveia, Mateus Henrique Bentley, Amy R. Leonard, Hampton Meeks, Karlijn A. C. Ekoru, Kenneth Chen, Guanjie Nalls, Michael A. Simonsick, Eleanor M. Santos, Eduardo Tarazona Costa, Maria Fernanda Furtado Lima Adeyemo, Adebowale Shriner, Daniel Rotimi, Charles N. |
| author_role |
author |
| author2 |
Bentley, Amy R. Leonard, Hampton Meeks, Karlijn A. C. Ekoru, Kenneth Chen, Guanjie Nalls, Michael A. Simonsick, Eleanor M. Santos, Eduardo Tarazona Costa, Maria Fernanda Furtado Lima Adeyemo, Adebowale Shriner, Daniel Rotimi, Charles N. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gouveia, Mateus Henrique Bentley, Amy R. Leonard, Hampton Meeks, Karlijn A. C. Ekoru, Kenneth Chen, Guanjie Nalls, Michael A. Simonsick, Eleanor M. Santos, Eduardo Tarazona Costa, Maria Fernanda Furtado Lima Adeyemo, Adebowale Shriner, Daniel Rotimi, Charles N. |
| description |
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA |
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2021 |
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2021 |
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2022-02-14T13:37:36Z |
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2022-02-14T13:37:36Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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GOUVEIA, Mateus Henrique et al. Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits. Sci Rep., v. 11, 4075, 2021. https://doi.org/10.1038/s41598-021-83450-3 |
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https://www.arca.fiocruz.br/handle/icict/51169 |
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2045-2322 |
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GOUVEIA, Mateus Henrique et al. Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits. Sci Rep., v. 11, 4075, 2021. https://doi.org/10.1038/s41598-021-83450-3 2045-2322 |
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Nature |
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