Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47758 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Rossi, Átila DuqueAraújo, João Locke Ferreira deAlmeida, Tailah Bernardo deRibeiro-Alves, MarceloVelozo, Camila de AlmeidaAlmeida, Jéssica Maciel deLeitão, Isabela de CarvalhoFerreira, Sâmila NatianeOliveira, Jéssica da SilvaAlves, Hugo JoséScheid, Helena ToledoFaffe, Débora SouzaGalliez, Rafael MelloÁvila, Renata Eliane deResende, Gustavo GomesTeixeira, Mauro MartinsFerreira Júnior, Orlando da CostaCastiñeiras, Terezinha Marta P. P.Souza, Renan PedraTanuri, AmilcarAguiar, Renato Santana deBarroso, Shana Priscila CoutinhoCardoso, Cynthia ChesterCOVID-19 UFRJ Workgroup2021-06-18T12:20:47Z2021-06-18T12:20:47Z2021ROSSI, Átila Duque et al. Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress. Scientific reports v. 11, n. 1, p. 1-9, 20212045-2322https://www.arca.fiocruz.br/handle/icict/4775810.1038/s41598-021-88944-8engNatureAssociation between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distressinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Biologia Integrativa. Belo Horizonte, MG, Brasil.Marinha do Brasil. Instituto de Estudos do Mar Almirante Paulo Moreira. Arraial do Cabo, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica. Rio de Janeiro, RJ, Brasil.Marinha do Brasil. Hospital Naval Marcílio Dias. Instituto de Pesquisas Biomédicas. Rio de Janeiro, RJ, Brasil.Marinha do Brasil. Hospital Naval Marcílio Dias. Instituto de Pesquisas Biomédicas. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Biologia Integrativa. Belo Horizonte, MG, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Biologia Integrativa. Belo Horizonte, MG, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética, Ecologia e Evolução. Laboratório de Biologia Integrativa. Belo Horizonte, MG, Brasil.Marinha do Brasil. Hospital Naval Marcílio Dias. Instituto de Pesquisas Biomédicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.ACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case-control study was conducted with 213 SARS-CoV-2 positive individuals where cases were defined as COVID-19 patients with respiratory distress requiring oxygen support (N = 38) and controls were those with mild to moderate symptoms of the disease who did not need oxygen therapy along the entire clinical course (N = 175). ACE2 and TMPRSS2 mRNA levels were evaluated in nasopharyngeal swab samples by RT-qPCR and logistic regression analyzes were applied to estimate associations with respiratory outcomes. ACE2 and TMPRSS2 levels positively correlated with age, which was also strongly associated with respiratory distress. Increased nasopharyngeal ACE2 levels showed a protective effect against this outcome (adjOR = 0.30; 95% CI 0.09-0.91), while TMPRSS2/ACE2 ratio was associated with risk (adjOR = 4.28; 95% CI 1.36-13.48). On stepwise regression, TMPRSS2/ACE2 ratio outperformed ACE2 to model COVID-19 severity. When nasopharyngeal swabs were compared to bronchoalveolar lavages in an independent cohort of COVID-19 patients under mechanical ventilation, similar expression levels of these genes were observed. These data suggest nasopharyngeal TMPRSS2/ACE2 as a promising candidate for further prediction models on COVID-19.SARS-CoV-2VirologyViral infectionGene expressionInfectious diseasesRespiratory tract diseasesEpidemiologyTranscriptioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/47758/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALAssociation_Marcelo_Alves_etal_INI_2021_COVID-19.pdfAssociation_Marcelo_Alves_etal_INI_2021_COVID-19.pdfapplication/pdf1242184https://www.arca.fiocruz.br/bitstream/icict/47758/2/Association_Marcelo_Alves_etal_INI_2021_COVID-19.pdfa56835f0434c4b3f633c7fbafc203459MD52TEXTAssociation_Marcelo_Alves_etal_INI_2021_COVID-19.pdf.txtAssociation_Marcelo_Alves_etal_INI_2021_COVID-19.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress |
| title |
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress |
| spellingShingle |
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress Rossi, Átila Duque SARS-CoV-2 Virology Viral infection Gene expression Infectious diseases Respiratory tract diseases Epidemiology Transcription |
| title_short |
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress |
| title_full |
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress |
| title_fullStr |
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress |
| title_full_unstemmed |
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress |
| title_sort |
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress |
| author |
Rossi, Átila Duque |
| author_facet |
Rossi, Átila Duque Araújo, João Locke Ferreira de Almeida, Tailah Bernardo de Ribeiro-Alves, Marcelo Velozo, Camila de Almeida Almeida, Jéssica Maciel de Leitão, Isabela de Carvalho Ferreira, Sâmila Natiane Oliveira, Jéssica da Silva Alves, Hugo José Scheid, Helena Toledo Faffe, Débora Souza Galliez, Rafael Mello Ávila, Renata Eliane de Resende, Gustavo Gomes Teixeira, Mauro Martins Ferreira Júnior, Orlando da Costa Castiñeiras, Terezinha Marta P. P. Souza, Renan Pedra Tanuri, Amilcar Aguiar, Renato Santana de Barroso, Shana Priscila Coutinho Cardoso, Cynthia Chester COVID-19 UFRJ Workgroup |
| author_role |
author |
| author2 |
Araújo, João Locke Ferreira de Almeida, Tailah Bernardo de Ribeiro-Alves, Marcelo Velozo, Camila de Almeida Almeida, Jéssica Maciel de Leitão, Isabela de Carvalho Ferreira, Sâmila Natiane Oliveira, Jéssica da Silva Alves, Hugo José Scheid, Helena Toledo Faffe, Débora Souza Galliez, Rafael Mello Ávila, Renata Eliane de Resende, Gustavo Gomes Teixeira, Mauro Martins Ferreira Júnior, Orlando da Costa Castiñeiras, Terezinha Marta P. P. Souza, Renan Pedra Tanuri, Amilcar Aguiar, Renato Santana de Barroso, Shana Priscila Coutinho Cardoso, Cynthia Chester COVID-19 UFRJ Workgroup |
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author author author author author author author author author author author author author author author author author author author author author author author |
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Rossi, Átila Duque Araújo, João Locke Ferreira de Almeida, Tailah Bernardo de Ribeiro-Alves, Marcelo Velozo, Camila de Almeida Almeida, Jéssica Maciel de Leitão, Isabela de Carvalho Ferreira, Sâmila Natiane Oliveira, Jéssica da Silva Alves, Hugo José Scheid, Helena Toledo Faffe, Débora Souza Galliez, Rafael Mello Ávila, Renata Eliane de Resende, Gustavo Gomes Teixeira, Mauro Martins Ferreira Júnior, Orlando da Costa Castiñeiras, Terezinha Marta P. P. Souza, Renan Pedra Tanuri, Amilcar Aguiar, Renato Santana de Barroso, Shana Priscila Coutinho Cardoso, Cynthia Chester COVID-19 UFRJ Workgroup |
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SARS-CoV-2 Virology Viral infection Gene expression Infectious diseases Respiratory tract diseases Epidemiology Transcription |
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SARS-CoV-2 Virology Viral infection Gene expression Infectious diseases Respiratory tract diseases Epidemiology Transcription |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-06-18T12:20:47Z |
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2021-06-18T12:20:47Z |
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2021 |
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ROSSI, Átila Duque et al. Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress. Scientific reports v. 11, n. 1, p. 1-9, 2021 |
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https://www.arca.fiocruz.br/handle/icict/47758 |
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2045-2322 |
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10.1038/s41598-021-88944-8 |
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ROSSI, Átila Duque et al. Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress. Scientific reports v. 11, n. 1, p. 1-9, 2021 2045-2322 10.1038/s41598-021-88944-8 |
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Nature |
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