Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46314 |
Resumo: | Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. |
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Kurtz, PedroRighy, CassiaGadelha, MonicaBozza, Fernando A.Bozza, Patrícia T.Gonçalves, BrunoBastos, Leonardo S. L.Vale, Andre M.Higa, Luiza M.Castilho, LedaMonteiro, Fabio L.Charris, NestorFialho, FernandaTuron, RicardoGueterrez, AlexandroMiranda, Rena LyraLima, Carlos Henrique de AzeredoCaro, Vanessa dePrazeres, Marco AurelioVentura, NinaGaspari, ClaraMiranda, FabioMata, Paulo José daPêcego, MargaridaMateos Sheila, SheilaLopes, Maria EstherCasrilho, ShirleyOliveira, ÁlvaroBioquimpani, CarlaRabello, AndreaLopes, JosianeConceição Neto, OrlandoFerreira Jr., Orlando da C.Tanuri, AmilcarNiemeyer Filho, PauloAmorim, Luiz2021-03-09T14:54:19Z2021-03-09T14:54:19Z2021KURTZ, Pedro et al. Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study. Frontiers in Medicine, v. 8, Article 630982, p. 1-9, Jan. 2021.2296-858Xhttps://www.arca.fiocruz.br/handle/icict/4631410.3389/fmed.2021.630982engFrontiers MediaPlasma convalescenteCoronavírusSíndrome do desconforto respiratório agudoCOVID-19SobrevivênciaConvalescent plasmaCoronavirusAcute respiratory distress syndromeCOVID-19SurvivalEffect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto D`Or de Educação e Pesquisa. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Doenças Infecciosas Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacollgia. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Engenharia Industrial. Rio de Janeiro,. RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Biologia de Linfócitos. Programa de Imunobiologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. COPPE. Programa de Engenharia Química. Laboratório de Engenharia de Cultura Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biologia. Departamento de Genética. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti. Rio de Janeiro, RJ, Brasil.Background: Convalescent plasma is a potential therapeutic option for critically ill patients with coronavirus disease 19 (COVID-19), yet its efficacy remains to be determined. The aim was to investigate the effects of convalescent plasma (CP) in critically ill patients with COVID-19. Methods: This was a single-center prospective observational study conducted in Rio de Janeiro, Brazil, from March 17th to May 30th, with final follow-up on June 30th. We included 113 laboratory-confirmed COVID-19 patients with respiratory failure. Primary outcomes were time to clinical improvement and survival within 28 days. Secondary outcomes included behavior of biomarkers and viral loads. Kaplan–Meier analyses and Cox proportional-hazards regression using propensity score with inverse-probability weighing were performed. Results: 41 patients received CP and 72 received standard of care (SOC). Median age was 61 years (IQR 48–68), disease duration was 10 days (IQR 6–13), and 86% were mechanically ventilated. At least 29 out of 41CP-recipients had baseline IgG titers ≥ 1:1,080. Clinical improvement within 28 days occurred in 19 (46%) CP-treated patients, as compared to 23 (32%) in the SOC group [adjusted hazard ratio (aHR) 0.91 (0.49–1.69)]. There was no significant change in 28-day mortality (CP 49% vs. SOC 56%; aHR 0.90 [0.52–1.57]). Biomarker assessment revealed reduced inflammatory activity and increased lymphocyte count after CP. Conclusions: In this study, CP was not associated with clinical improvement or increase in 28-day survival. However, our study may have been underpowered and included patients with high IgG titers and life-threatening disease. Clinical Trial Registration: The study protocol was retrospectively registered at the Brazilian Registry of Clinical Trials (ReBEC) with the identification RBR-4vm3yy (http:// www.ensaiosclinicos.gov.br).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46314/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaT_Bozza_etal_IOC_2021.pdfPatriciaT_Bozza_etal_IOC_2021.pdfapplication/pdf768905https://www.arca.fiocruz.br/bitstream/icict/46314/2/PatriciaT_Bozza_etal_IOC_2021.pdfa13d7816d716c1453a3506c93bee430aMD52TEXTPatriciaT_Bozza_etal_IOC_2021.pdf.txtPatriciaT_Bozza_etal_IOC_2021.pdf.txtExtracted texttext/plain41653https://www.arca.fiocruz.br/bitstream/icict/46314/3/PatriciaT_Bozza_etal_IOC_2021.pdf.txtea5eefa3b6c3fa20b5a4330159ab29e8MD53icict/463142022-06-24 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| dc.title.pt_BR.fl_str_mv |
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study |
| title |
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study |
| spellingShingle |
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study Kurtz, Pedro Plasma convalescente Coronavírus Síndrome do desconforto respiratório agudo COVID-19 Sobrevivência Convalescent plasma Coronavirus Acute respiratory distress syndrome COVID-19 Survival |
| title_short |
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study |
| title_full |
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study |
| title_fullStr |
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study |
| title_full_unstemmed |
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study |
| title_sort |
Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study |
| author |
Kurtz, Pedro |
| author_facet |
Kurtz, Pedro Righy, Cassia Gadelha, Monica Bozza, Fernando A. Bozza, Patrícia T. Gonçalves, Bruno Bastos, Leonardo S. L. Vale, Andre M. Higa, Luiza M. Castilho, Leda Monteiro, Fabio L. Charris, Nestor Fialho, Fernanda Turon, Ricardo Gueterrez, Alexandro Miranda, Rena Lyra Lima, Carlos Henrique de Azeredo Caro, Vanessa de Prazeres, Marco Aurelio Ventura, Nina Gaspari, Clara Miranda, Fabio Mata, Paulo José da Pêcego, Margarida Mateos Sheila, Sheila Lopes, Maria Esther Casrilho, Shirley Oliveira, Álvaro Bioquimpani, Carla Rabello, Andrea Lopes, Josiane Conceição Neto, Orlando Ferreira Jr., Orlando da C. Tanuri, Amilcar Niemeyer Filho, Paulo Amorim, Luiz |
| author_role |
author |
| author2 |
Righy, Cassia Gadelha, Monica Bozza, Fernando A. Bozza, Patrícia T. Gonçalves, Bruno Bastos, Leonardo S. L. Vale, Andre M. Higa, Luiza M. Castilho, Leda Monteiro, Fabio L. Charris, Nestor Fialho, Fernanda Turon, Ricardo Gueterrez, Alexandro Miranda, Rena Lyra Lima, Carlos Henrique de Azeredo Caro, Vanessa de Prazeres, Marco Aurelio Ventura, Nina Gaspari, Clara Miranda, Fabio Mata, Paulo José da Pêcego, Margarida Mateos Sheila, Sheila Lopes, Maria Esther Casrilho, Shirley Oliveira, Álvaro Bioquimpani, Carla Rabello, Andrea Lopes, Josiane Conceição Neto, Orlando Ferreira Jr., Orlando da C. Tanuri, Amilcar Niemeyer Filho, Paulo Amorim, Luiz |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
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Kurtz, Pedro Righy, Cassia Gadelha, Monica Bozza, Fernando A. Bozza, Patrícia T. Gonçalves, Bruno Bastos, Leonardo S. L. Vale, Andre M. Higa, Luiza M. Castilho, Leda Monteiro, Fabio L. Charris, Nestor Fialho, Fernanda Turon, Ricardo Gueterrez, Alexandro Miranda, Rena Lyra Lima, Carlos Henrique de Azeredo Caro, Vanessa de Prazeres, Marco Aurelio Ventura, Nina Gaspari, Clara Miranda, Fabio Mata, Paulo José da Pêcego, Margarida Mateos Sheila, Sheila Lopes, Maria Esther Casrilho, Shirley Oliveira, Álvaro Bioquimpani, Carla Rabello, Andrea Lopes, Josiane Conceição Neto, Orlando Ferreira Jr., Orlando da C. Tanuri, Amilcar Niemeyer Filho, Paulo Amorim, Luiz |
| dc.subject.other.pt_BR.fl_str_mv |
Plasma convalescente Coronavírus Síndrome do desconforto respiratório agudo COVID-19 Sobrevivência |
| topic |
Plasma convalescente Coronavírus Síndrome do desconforto respiratório agudo COVID-19 Sobrevivência Convalescent plasma Coronavirus Acute respiratory distress syndrome COVID-19 Survival |
| dc.subject.en.pt_BR.fl_str_mv |
Convalescent plasma Coronavirus Acute respiratory distress syndrome COVID-19 Survival |
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Instituto Estadual do Cérebro Paulo Niemeyer. Rio de Janeiro, RJ, Brasil. |
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2021 |
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2021-03-09T14:54:19Z |
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2021-03-09T14:54:19Z |
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2021 |
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info:eu-repo/semantics/article |
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KURTZ, Pedro et al. Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study. Frontiers in Medicine, v. 8, Article 630982, p. 1-9, Jan. 2021. |
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https://www.arca.fiocruz.br/handle/icict/46314 |
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2296-858X |
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10.3389/fmed.2021.630982 |
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KURTZ, Pedro et al. Effect of Convalescent Plasma in Critically Ill Patients With COVID-19: An Observational Study. Frontiers in Medicine, v. 8, Article 630982, p. 1-9, Jan. 2021. 2296-858X 10.3389/fmed.2021.630982 |
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