Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows

Detalhes bibliográficos
Autor(a) principal: Pina-Araujo, Isabel Inês M. de
Data de Publicação: 2018
Outros Autores: Spitz, Natalia, Soares, Caroline C., Niel, Christian, Lago, Barbara V., Gomes, Selma A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28748
Resumo: Universidade de Cabo Verde. Faculdade de Ciência e Tecnologia. Praia, Santiago, Cabo Verde.
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spelling Pina-Araujo, Isabel Inês M. deSpitz, NataliaSoares, Caroline C.Niel, ChristianLago, Barbara V.Gomes, Selma A.2018-09-13T16:47:40Z2018-09-13T16:47:40Z2018PINA-ARAUJO, Isabel Inês M. de; et al. Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows. Plos One, v.13, n.2, e0192596, Feb. 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/2874810.1371/journal.pone.0192595engPublic Library of ScienceVírus da Hepatite BCabo VerdeGenótiposFluxos humanosHepatitis B virusCape Verdegenotpeshuman flowsHepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flowsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Cabo Verde. Faculdade de Ciência e Tecnologia. Praia, Santiago, Cabo Verde.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de tecnologia em Imunibiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Hepatitis B virus (HBV) diversity has not been previously studied in Cape Verde. The archipelago was discovered in 1460 by Portuguese explorers, who brought African slaves to colonise the islands. In this study, we investigated the HBV characteristics from 183 HBsAg-positive Cape Verdean individuals. Phylogenetic analysis of the pre-S/S region and the full-length genomes revealed 54 isolates with HBV/A1 (57%), 21 with HBV/A2 (22%), 19 with HBV/E (20%), and one with HBV/D (1%). HBV genotypes and subgenotypes were unequally distributed through the islands. In São Vicente, the main northern island, most isolates (84%) belonged to the African-originated HBV/A1, with the remaining isolates belonging to HBV/A2, which is prevalent in Europe. Interestingly, the HBV/A1 isolates from São Vicente were closely related to Brazilian sequences into the Asian-American clade, which suggests the dissemination of common African ancestors through slave trade. In contrast, in Santiago and nearby southern islands, where a recent influx from different populations circulates, a higher diversity of HBV was observed: HBV/A1 (40%); HBV/E (32%); HBV/A2 (28%); and HBV/D (1%). HBV/E is a recent genotype disseminated in Africa that was absent in the era of the slave trade. African and European human flows at different times of the history may explain the HBV diversity in Cape Verde. The possible origin and specifics of each HBV genotype circulating in Cape Verde are discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28748/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALnatalia_spitz_etal_IOC_2018.pdfnatalia_spitz_etal_IOC_2018.pdfapplication/pdf4119264https://www.arca.fiocruz.br/bitstream/icict/28748/2/natalia_spitz_etal_IOC_2018.pdf2e152b76fd598a7f061a886c8b33ff2aMD52TEXTnatalia_spitz_etal_IOC_2018.pdf.txtnatalia_spitz_etal_IOC_2018.pdf.txtExtracted texttext/plain55604https://www.arca.fiocruz.br/bitstream/icict/28748/3/natalia_spitz_etal_IOC_2018.pdf.txt70b7b8bb0edc6e5e833441d618f6cfc9MD53icict/287482018-09-14 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dc.title.pt_BR.fl_str_mv Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows
title Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows
spellingShingle Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows
Pina-Araujo, Isabel Inês M. de
Vírus da Hepatite B
Cabo Verde
Genótipos
Fluxos humanos
Hepatitis B virus
Cape Verde
genotpes
human flows
title_short Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows
title_full Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows
title_fullStr Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows
title_full_unstemmed Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows
title_sort Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows
author Pina-Araujo, Isabel Inês M. de
author_facet Pina-Araujo, Isabel Inês M. de
Spitz, Natalia
Soares, Caroline C.
Niel, Christian
Lago, Barbara V.
Gomes, Selma A.
author_role author
author2 Spitz, Natalia
Soares, Caroline C.
Niel, Christian
Lago, Barbara V.
Gomes, Selma A.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pina-Araujo, Isabel Inês M. de
Spitz, Natalia
Soares, Caroline C.
Niel, Christian
Lago, Barbara V.
Gomes, Selma A.
dc.subject.other.pt_BR.fl_str_mv Vírus da Hepatite B
Cabo Verde
Genótipos
Fluxos humanos
topic Vírus da Hepatite B
Cabo Verde
Genótipos
Fluxos humanos
Hepatitis B virus
Cape Verde
genotpes
human flows
dc.subject.en.pt_BR.fl_str_mv Hepatitis B virus
Cape Verde
genotpes
human flows
description Universidade de Cabo Verde. Faculdade de Ciência e Tecnologia. Praia, Santiago, Cabo Verde.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-09-13T16:47:40Z
dc.date.available.fl_str_mv 2018-09-13T16:47:40Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PINA-ARAUJO, Isabel Inês M. de; et al. Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows. Plos One, v.13, n.2, e0192596, Feb. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28748
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0192595
identifier_str_mv PINA-ARAUJO, Isabel Inês M. de; et al. Hepatitis B virus genotypes A1, A2 and E in Cape Verde: Unequal distribution through the islands and association with human flows. Plos One, v.13, n.2, e0192596, Feb. 2018.
1932-6203
10.1371/journal.pone.0192595
url https://www.arca.fiocruz.br/handle/icict/28748
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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