Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection

Detalhes bibliográficos
Autor(a) principal: Portilho, Moyra Machado
Data de Publicação: 2020
Outros Autores: Moraes, Laise de, Kikuti, Mariana, Nascimento, Leile Camila Jacob, Reis, Mitermayer Galvão dos, Boaventura, Viviane Sampaio, Cunha, Antonio Ricardo Khouri, Ribeiro, Guilherme de Sousa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44378
Resumo: Brazilian National Council for Scientific and Technological Development (grant 550160/2010-8 to MGR, grants 400830/2013-2 and 440891/2016-7 to GSR, grant 439967/2016-3 to RK, and scholarships to MGR and GSR); the Bahia Foundation for Research Support (grant PNX0010/2011 to MGR, grants PPP0055/2011, JCB0020/2013, PET0026/2013, APP0044/2016, and PET0022/2016 to GSR); and the Coordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education (grant 88887.130746/2016-00 to GSR and scholarships to MMP, LM, MK and LCJN).
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spelling Portilho, Moyra MachadoMoraes, Laise deKikuti, MarianaNascimento, Leile Camila JacobReis, Mitermayer Galvão dosBoaventura, Viviane SampaioCunha, Antonio Ricardo KhouriRibeiro, Guilherme de Sousa2020-11-12T12:24:37Z2020-11-12T12:24:37Z2020PORTILHO, Moyra Machado et al. Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection. Diagnostics, v. 10, 2020.2075-4418https://www.arca.fiocruz.br/handle/icict/4437810.3390/diagnostics10100835Brazilian National Council for Scientific and Technological Development (grant 550160/2010-8 to MGR, grants 400830/2013-2 and 440891/2016-7 to GSR, grant 439967/2016-3 to RK, and scholarships to MGR and GSR); the Bahia Foundation for Research Support (grant PNX0010/2011 to MGR, grants PPP0055/2011, JCB0020/2013, PET0026/2013, APP0044/2016, and PET0022/2016 to GSR); and the Coordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education (grant 88887.130746/2016-00 to GSR and scholarships to MMP, LM, MK and LCJN).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Serological diagnosis of Zika virus (ZIKV) infection is challenging because of antigenic cross-reactivity with dengue virus (DENV). This study evaluated the accuracy of the Zika IgM antibody capture enzyme-linked immunosorbent assay (CDC Zika IgM MAC-ELISA) in di erentiating between ZIKV and DENV infections. To determine sensitivity, we used acute- and convalescent-phase sera from 21 patients with RT-PCR-confirmed ZIKV infection. To determine specificity, we used acuteand convalescent-phase sera from 60 RT-PCR-confirmed dengue cases and sera from 23 blood donors. During the acute-phase of the illness, the assay presented a sensitivity of 12.5% (2/16) for samples collected 0–4 days post symptoms onset (DPSO), and of 75.0% (3/4) for samples collected 5–9 DPSO. During the convalescent-phase of the illness, the test sensitivity was 90.9% (10/11), 100% (2/2), and 0% (0/2) for samples obtained 12–102, 258–260, and 722–727 DPSO, respectively. Specificity for acute- and convalescent-phase samples from RT-PCR-confirmed dengue cases was 100% and 93.2%, respectively. Specificity for blood donor samples was 100%. The assay is an accurate method for Zika serological diagnosis and proved to be reliable for use during surveillance and outbreak investigations in settings where ZIKV and DENV cocirculate.engMDPIVírus ZikaDiagnósticoSensibilidade e especificidadeEnsaio de imunoadsorção enzimáticaCDC Center for Disease Control and PreventionZika virusDiagnostic accuracySensitivity and specificityEnzyme-linked immunosorbent assayCDC ZikaMAC-ELISAAccuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/44378/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALPortilho, Moyra Machado. 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dc.title.pt_BR.fl_str_mv Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
title Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
spellingShingle Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
Portilho, Moyra Machado
Vírus Zika
Diagnóstico
Sensibilidade e especificidade
Ensaio de imunoadsorção enzimática
CDC Center for Disease Control and Prevention
Zika virus
Diagnostic accuracy
Sensitivity and specificity
Enzyme-linked immunosorbent assay
CDC ZikaMAC-ELISA
title_short Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
title_full Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
title_fullStr Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
title_full_unstemmed Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
title_sort Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
author Portilho, Moyra Machado
author_facet Portilho, Moyra Machado
Moraes, Laise de
Kikuti, Mariana
Nascimento, Leile Camila Jacob
Reis, Mitermayer Galvão dos
Boaventura, Viviane Sampaio
Cunha, Antonio Ricardo Khouri
Ribeiro, Guilherme de Sousa
author_role author
author2 Moraes, Laise de
Kikuti, Mariana
Nascimento, Leile Camila Jacob
Reis, Mitermayer Galvão dos
Boaventura, Viviane Sampaio
Cunha, Antonio Ricardo Khouri
Ribeiro, Guilherme de Sousa
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Portilho, Moyra Machado
Moraes, Laise de
Kikuti, Mariana
Nascimento, Leile Camila Jacob
Reis, Mitermayer Galvão dos
Boaventura, Viviane Sampaio
Cunha, Antonio Ricardo Khouri
Ribeiro, Guilherme de Sousa
dc.subject.other.pt_BR.fl_str_mv Vírus Zika
Diagnóstico
Sensibilidade e especificidade
Ensaio de imunoadsorção enzimática
CDC Center for Disease Control and Prevention
topic Vírus Zika
Diagnóstico
Sensibilidade e especificidade
Ensaio de imunoadsorção enzimática
CDC Center for Disease Control and Prevention
Zika virus
Diagnostic accuracy
Sensitivity and specificity
Enzyme-linked immunosorbent assay
CDC ZikaMAC-ELISA
dc.subject.en.pt_BR.fl_str_mv Zika virus
Diagnostic accuracy
Sensitivity and specificity
Enzyme-linked immunosorbent assay
CDC ZikaMAC-ELISA
description Brazilian National Council for Scientific and Technological Development (grant 550160/2010-8 to MGR, grants 400830/2013-2 and 440891/2016-7 to GSR, grant 439967/2016-3 to RK, and scholarships to MGR and GSR); the Bahia Foundation for Research Support (grant PNX0010/2011 to MGR, grants PPP0055/2011, JCB0020/2013, PET0026/2013, APP0044/2016, and PET0022/2016 to GSR); and the Coordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education (grant 88887.130746/2016-00 to GSR and scholarships to MMP, LM, MK and LCJN).
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-11-12T12:24:37Z
dc.date.available.fl_str_mv 2020-11-12T12:24:37Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv PORTILHO, Moyra Machado et al. Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection. Diagnostics, v. 10, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44378
dc.identifier.issn.pt_BR.fl_str_mv 2075-4418
dc.identifier.doi.none.fl_str_mv 10.3390/diagnostics10100835
identifier_str_mv PORTILHO, Moyra Machado et al. Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection. Diagnostics, v. 10, 2020.
2075-4418
10.3390/diagnostics10100835
url https://www.arca.fiocruz.br/handle/icict/44378
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
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