Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy

Detalhes bibliográficos
Autor(a) principal: Costa, Rúbia Suely Santana
Data de Publicação: 2018
Outros Autores: Carvalho, Lucas Pedreira de, Britto, Taís Menezes Cerqueira Campos de, Magalhães, Andréa S, Passos, Sara Timoteo, Schriefer, Albert, Silva, Juliana A, Lago, Ednaldo, Paixão, Camilla Santos, Machado, Paulo Roberto Lima, Scott, Phillip, Carvalho Filho, Edgar Marcelino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25002
Resumo: National Institutes of Health (Grant U01 AI088650-06)
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spelling Costa, Rúbia Suely SantanaCarvalho, Lucas Pedreira deBritto, Taís Menezes Cerqueira Campos deMagalhães, Andréa SPassos, Sara TimoteoSchriefer, AlbertSilva, Juliana ALago, EdnaldoPaixão, Camilla SantosMachado, Paulo Roberto LimaScott, PhillipCarvalho Filho, Edgar Marcelino2018-02-28T17:51:42Z2018-02-28T17:51:42Z2018COSTA, R. S. S. et al. Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy. The Journal of Infectious Diseases, v. 217, p. 840–850, 2018.0022-1899https://www.arca.fiocruz.br/handle/icict/2500210.1093/infdis/jix627National Institutes of Health (Grant U01 AI088650-06)Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / University of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PAUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversity of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PAUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilEarly cutaneous leishmaniasis (ECL) is characterized by a nonulcerated papular lesion and illness duration less than 30 days. Approximately 4 weeks later, the cutaneous leishmaniasis (CL) ulcers appear. We were surprised to find that failure after antimony therapy (Sb5) is higher in ECL than CL. We hypothesize that the inflammatory response in ECL patients may increase during Sb5 therapy, which leads to treatment failure. Methods. A cohort of 44 ECL patients infected by Leishmania braziliensis was established to evaluate the response to Sb5 and to compare immunologic responses in ECL patients with CL and healthy subjects. Results. A hierarchical clustering based on cytokine levels showed a weak positive correlation between proinflammatory cytokine levels and those patients that failed Sb5 treatment. Although Sb5 therapy decreased interferon-γ and tumor necrosis factor levels in CL patients, we were surprised to find that an increase in these cytokines was observed in ECL patients. Moreover, interleukin (IL)-10 was less able to down-modulate immune responses in ECL. Conclusions. The enhanced production of proinflammatory cytokines, due in part to the decreased ability of IL-10 to down-modulate immune response during therapy in ECL, promotes the development and persistence of leishmania ulcer despite antimony therapy.engUniversity of Chicago PressLeishmaniose cutânea precoceQuimiocinasLeishmaniose cutâneaLeishmania braziliensisCitocinasEarly cutaneous leishmaniasisChemokinesCutaneous leishmaniasisLeishmania braziliensisCytokinesEarly Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25002/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCosta RS Early Cutaneous 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dc.title.pt_BR.fl_str_mv Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
title Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
spellingShingle Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
Costa, Rúbia Suely Santana
Leishmaniose cutânea precoce
Quimiocinas
Leishmaniose cutânea
Leishmania braziliensis
Citocinas
Early cutaneous leishmaniasis
Chemokines
Cutaneous leishmaniasis
Leishmania braziliensis
Cytokines
title_short Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
title_full Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
title_fullStr Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
title_full_unstemmed Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
title_sort Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
author Costa, Rúbia Suely Santana
author_facet Costa, Rúbia Suely Santana
Carvalho, Lucas Pedreira de
Britto, Taís Menezes Cerqueira Campos de
Magalhães, Andréa S
Passos, Sara Timoteo
Schriefer, Albert
Silva, Juliana A
Lago, Ednaldo
Paixão, Camilla Santos
Machado, Paulo Roberto Lima
Scott, Phillip
Carvalho Filho, Edgar Marcelino
author_role author
author2 Carvalho, Lucas Pedreira de
Britto, Taís Menezes Cerqueira Campos de
Magalhães, Andréa S
Passos, Sara Timoteo
Schriefer, Albert
Silva, Juliana A
Lago, Ednaldo
Paixão, Camilla Santos
Machado, Paulo Roberto Lima
Scott, Phillip
Carvalho Filho, Edgar Marcelino
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Rúbia Suely Santana
Carvalho, Lucas Pedreira de
Britto, Taís Menezes Cerqueira Campos de
Magalhães, Andréa S
Passos, Sara Timoteo
Schriefer, Albert
Silva, Juliana A
Lago, Ednaldo
Paixão, Camilla Santos
Machado, Paulo Roberto Lima
Scott, Phillip
Carvalho Filho, Edgar Marcelino
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea precoce
Quimiocinas
Leishmaniose cutânea
Leishmania braziliensis
Citocinas
topic Leishmaniose cutânea precoce
Quimiocinas
Leishmaniose cutânea
Leishmania braziliensis
Citocinas
Early cutaneous leishmaniasis
Chemokines
Cutaneous leishmaniasis
Leishmania braziliensis
Cytokines
dc.subject.en.pt_BR.fl_str_mv Early cutaneous leishmaniasis
Chemokines
Cutaneous leishmaniasis
Leishmania braziliensis
Cytokines
description National Institutes of Health (Grant U01 AI088650-06)
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-02-28T17:51:42Z
dc.date.available.fl_str_mv 2018-02-28T17:51:42Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, R. S. S. et al. Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy. The Journal of Infectious Diseases, v. 217, p. 840–850, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25002
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jix627
identifier_str_mv COSTA, R. S. S. et al. Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy. The Journal of Infectious Diseases, v. 217, p. 840–850, 2018.
0022-1899
10.1093/infdis/jix627
url https://www.arca.fiocruz.br/handle/icict/25002
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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