Resveratrol Reverses Functional Chagas Heart Disease in Mice

Pereira, Glaucia Vilar; Carneiro, Vitor C.; Santos, Hilton Mata; Vicentino, Amanda R. R.; Ramos, Isalira P.; Giarola, Naira L. L.; Feijó, Daniel F.; Fernandes, José R. Meyer; Paula Neto, Heitor A.; Medei, Emiliano; Bozza, Marcelo T.; Vieira, Joseli Lannes; Paiva, Claudia N.

Resveratrol Reverses Functional Chagas Heart Disease in Mice

Detalhes bibliográficos
Autor(a) principal:	Pereira, Glaucia Vilar
Data de Publicação:	2016
Outros Autores:	Carneiro, Vitor C., Santos, Hilton Mata, Vicentino, Amanda R. R., Ramos, Isalira P., Giarola, Naira L. L., Feijó, Daniel F., Fernandes, José R. Meyer, Paula Neto, Heitor A., Medei, Emiliano, Bozza, Marcelo T., Vieira, Joseli Lannes, Paiva, Claudia N.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/18091
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil.

Metadados do item

id	CRUZ_579b770ade6166a411fc7e07ab18adcd
oai_identifier_str	oai:www.arca.fiocruz.br:icict/18091
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Pereira, Glaucia VilarCarneiro, Vitor C.Santos, Hilton MataVicentino, Amanda R. R.Ramos, Isalira P.Giarola, Naira L. L.Feijó, Daniel F.Fernandes, José R. MeyerPaula Neto, Heitor A.Medei, EmilianoBozza, Marcelo T.Vieira, Joseli LannesPaiva, Claudia N.2017-03-21T12:18:18Z2017-03-21T12:18:18Z2016PEREIRA, Glaucia Vilar; et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog, v.12, n.10, e1005947, 19p, Oct. 2016.1553-7366https://www.arca.fiocruz.br/handle/icict/1809110.1371/journal.ppat.10059471553-7374engPublic Library of ScienceCardiomiopatia chagásica crônicaRatosResveratrolChronic chagasic cardiomyopathyMiceResveratrolResveratrol Reverses Functional Chagas Heart Disease in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Molecular e Tecnologia, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas.Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Molecular e Tecnologia, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Radiologia, Rio de Janeiro, RJ, Brasil / Univerisdade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro Nacional de Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis, Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia da Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro Nacional de Biologia Estrutural e Bioimagem. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of parasite burden. During disease, the heart undergoes oxidative stress, a potential causative factor for arrhythmias and contractile dysfunction. Here we tested whether antioxidants/ cardioprotective drugs could improve cardiac function in established Chagas heart disease. We chose a model that resembles B1-B2 stage of human CCC, treated mice with resveratrol and performed electrocardiography and echocardiography studies. Resveratrol reduced the prolonged PR and QTc intervals, increased heart rates and reversed sinus arrhythmia, atrial and atrioventricular conduction disorders; restored a normal left ventricular ejection fraction, improved stroke volume and cardiac output. Resveratrol activated the AMPK-pathway and reduced both ROS production and heart parasite burden, without interfering with vascularization or myocarditis intensity. Resveratrol was even capable of improving heart function of infected mice when treatment was started late after infection, while trypanocidal drug benznidazole failed. We attempted to mimic resveratrol's actions using metformin (AMPK-activator) or tempol (SOD-mimetic). Metformin and tempol mimicked the beneficial effects of resveratrol on heart function and decreased lipid peroxidation, but did not alter parasite burden. These results indicate that AMPK activation and ROS neutralization are key strategies to induce tolerance to Chagas heart disease. Despite all tissue damage observed in established Chagas heart disease, we found that a physiological dysfunction can still be reversed by treatment with resveratrol, metformin and tempol, resulting in improved heart function and representing a starting point to develop innovative therapies in CCC.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18091/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALglaucia_pereira_etal_IOC_2016.pdfglaucia_pereira_etal_IOC_2016.pdfapplication/pdf4545847https://www.arca.fiocruz.br/bitstream/icict/18091/2/glaucia_pereira_etal_IOC_2016.pdfa4ddfd0cf63ee363ce0dafdc209a732dMD52TEXTglaucia_pereira_etal_IOC_2016.pdf.txtglaucia_pereira_etal_IOC_2016.pdf.txtExtracted texttext/plain63580https://www.arca.fiocruz.br/bitstream/icict/18091/3/glaucia_pereira_etal_IOC_2016.pdf.txtf02f8c13d14951a1eba73345eba4b890MD53icict/180912018-08-15 02:29:38.535oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-08-15T05:29:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Resveratrol Reverses Functional Chagas Heart Disease in Mice
title	Resveratrol Reverses Functional Chagas Heart Disease in Mice
spellingShingle	Resveratrol Reverses Functional Chagas Heart Disease in Mice Pereira, Glaucia Vilar Cardiomiopatia chagásica crônica Ratos Resveratrol Chronic chagasic cardiomyopathy Mice Resveratrol
title_short	Resveratrol Reverses Functional Chagas Heart Disease in Mice
title_full	Resveratrol Reverses Functional Chagas Heart Disease in Mice
title_fullStr	Resveratrol Reverses Functional Chagas Heart Disease in Mice
title_full_unstemmed	Resveratrol Reverses Functional Chagas Heart Disease in Mice
title_sort	Resveratrol Reverses Functional Chagas Heart Disease in Mice
author	Pereira, Glaucia Vilar
author_facet	Pereira, Glaucia Vilar Carneiro, Vitor C. Santos, Hilton Mata Vicentino, Amanda R. R. Ramos, Isalira P. Giarola, Naira L. L. Feijó, Daniel F. Fernandes, José R. Meyer Paula Neto, Heitor A. Medei, Emiliano Bozza, Marcelo T. Vieira, Joseli Lannes Paiva, Claudia N.
author_role	author
author2	Carneiro, Vitor C. Santos, Hilton Mata Vicentino, Amanda R. R. Ramos, Isalira P. Giarola, Naira L. L. Feijó, Daniel F. Fernandes, José R. Meyer Paula Neto, Heitor A. Medei, Emiliano Bozza, Marcelo T. Vieira, Joseli Lannes Paiva, Claudia N.
author2_role	author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Pereira, Glaucia Vilar Carneiro, Vitor C. Santos, Hilton Mata Vicentino, Amanda R. R. Ramos, Isalira P. Giarola, Naira L. L. Feijó, Daniel F. Fernandes, José R. Meyer Paula Neto, Heitor A. Medei, Emiliano Bozza, Marcelo T. Vieira, Joseli Lannes Paiva, Claudia N.
dc.subject.other.pt_BR.fl_str_mv	Cardiomiopatia chagásica crônica Ratos Resveratrol
topic	Cardiomiopatia chagásica crônica Ratos Resveratrol Chronic chagasic cardiomyopathy Mice Resveratrol
dc.subject.en.pt_BR.fl_str_mv	Chronic chagasic cardiomyopathy Mice Resveratrol
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ. Brasil.
publishDate	2016
dc.date.issued.fl_str_mv	2016
dc.date.accessioned.fl_str_mv	2017-03-21T12:18:18Z
dc.date.available.fl_str_mv	2017-03-21T12:18:18Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	PEREIRA, Glaucia Vilar; et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog, v.12, n.10, e1005947, 19p, Oct. 2016.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/18091
dc.identifier.issn.pt_BR.fl_str_mv	1553-7366
dc.identifier.doi.none.fl_str_mv	10.1371/journal.ppat.1005947
dc.identifier.eissn.none.fl_str_mv	1553-7374
identifier_str_mv	PEREIRA, Glaucia Vilar; et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog, v.12, n.10, e1005947, 19p, Oct. 2016. 1553-7366 10.1371/journal.ppat.1005947 1553-7374
url	https://www.arca.fiocruz.br/handle/icict/18091
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/18091/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/18091/2/glaucia_pereira_etal_IOC_2016.pdf https://www.arca.fiocruz.br/bitstream/icict/18091/3/glaucia_pereira_etal_IOC_2016.pdf.txt
bitstream.checksum.fl_str_mv	5a560609d32a3863062d77ff32785d58 a4ddfd0cf63ee363ce0dafdc209a732d f02f8c13d14951a1eba73345eba4b890
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1798325077246214144

Resveratrol Reverses Functional Chagas Heart Disease in Mice

Registros relacionados