Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.

Detalhes bibliográficos
Autor(a) principal: Abreu, Fabiano Carlos Pinto de
Data de Publicação: 2013
Outros Autores: Pereira, Roberta V., Oliveira, Victor Fernandes de, Gomes, Matheus de Souza, Passos, Liana Konovaloff Jannotti, Borges, William de Castro, Sá, Renata Guerra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30362
Resumo: 2020-01-01
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spelling Abreu, Fabiano Carlos Pinto dePereira, Roberta V.Oliveira, Victor Fernandes deGomes, Matheus de SouzaPassos, Liana Konovaloff JannottiBorges, William de CastroSá, Renata Guerra2018-12-03T15:46:40Z2018-12-03T15:46:40Z2013ABREU, Fabiano Carlos Pinto de et al. Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni. Parasitol Res., v. 112, n. 12, p. 4151-4159, 2013.0932-0113https://www.arca.fiocruz.br/handle/icict/3036210.1007/s00436-013-3606-xengSpringer VerlangVerme adultoAdult WormNuclear ExportNuclear Pore ComplexSchistosoma MansoniNuclear Export SignalCharacterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrazilUniversidade Federal de Uberlândia. Instituto de Genética e Bioquímica. Patos de Minas, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, BrazilSeveral proteins and different species of RNA that are produced in the nucleus are exported through the nuclear pore complexes, which require a family of conserved nuclear export receptors called exportins (XPOs). It has been reported that the XPOs (XPO1, XPO5, and XPOT) are directly involved in the transport processes of noncoding RNAs from the nucleus to the cytoplasm and/or from cytoplasm to the nucleus. All three genes are present in fungi, plants, and deuterostome metazoans. However, protostome metazoan species lack one of the three genes across evolution. In this report, we have demonstrated that all three XPO proteins are present in the parasite protostome Schistosoma mansoni . As this parasite has a complex life cycle presenting several stages in different hosts and environments, implying a differential gene regulation, we proposed a genomic analysis of XPOs to validate their annotation. The results showed the conservation of exportin family members and gene duplication events in S. mansoni .We performed quantitative RT-PCR, which revealed an upregulation of SmXPO1 in 24 h schistosomula (sixfold when compared with cercariae), and similar transcription levels were observed for SmXPO5 and SmXPOT in all the analyzed stages. These three XPO proteins have been identified for the first time in the protostome clade, which suggests a higher complexity in RNA transport in the parasite S. mansoni. Taken together, these results suggest that RNA transport by exportins might control cellular processes during cercariae, schistosomula, and adult worm development.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30362/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCharacterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.pdfCharacterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.pdfapplication/pdf358181https://www.arca.fiocruz.br/bitstream/icict/30362/2/Characterization%20of%20export%20receptor%20exportins%20%28XPOs%29%20in%20the%20parasite%20Schistosoma%20mansoni.pdfef988638fd1beb653345c459533096acMD52TEXTCharacterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.pdf.txtCharacterization of 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dc.title.pt_BR.fl_str_mv Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.
title Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.
spellingShingle Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.
Abreu, Fabiano Carlos Pinto de
Verme adulto
Adult Worm
Nuclear Export
Nuclear Pore Complex
Schistosoma Mansoni
Nuclear Export Signal
title_short Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.
title_full Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.
title_fullStr Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.
title_full_unstemmed Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.
title_sort Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni.
author Abreu, Fabiano Carlos Pinto de
author_facet Abreu, Fabiano Carlos Pinto de
Pereira, Roberta V.
Oliveira, Victor Fernandes de
Gomes, Matheus de Souza
Passos, Liana Konovaloff Jannotti
Borges, William de Castro
Sá, Renata Guerra
author_role author
author2 Pereira, Roberta V.
Oliveira, Victor Fernandes de
Gomes, Matheus de Souza
Passos, Liana Konovaloff Jannotti
Borges, William de Castro
Sá, Renata Guerra
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Abreu, Fabiano Carlos Pinto de
Pereira, Roberta V.
Oliveira, Victor Fernandes de
Gomes, Matheus de Souza
Passos, Liana Konovaloff Jannotti
Borges, William de Castro
Sá, Renata Guerra
dc.subject.other.pt_BR.fl_str_mv Verme adulto
topic Verme adulto
Adult Worm
Nuclear Export
Nuclear Pore Complex
Schistosoma Mansoni
Nuclear Export Signal
dc.subject.en.pt_BR.fl_str_mv Adult Worm
Nuclear Export
Nuclear Pore Complex
Schistosoma Mansoni
Nuclear Export Signal
description 2020-01-01
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-12-03T15:46:40Z
dc.date.available.fl_str_mv 2018-12-03T15:46:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ABREU, Fabiano Carlos Pinto de et al. Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni. Parasitol Res., v. 112, n. 12, p. 4151-4159, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30362
dc.identifier.issn.pt_BR.fl_str_mv 0932-0113
dc.identifier.doi.none.fl_str_mv 10.1007/s00436-013-3606-x
identifier_str_mv ABREU, Fabiano Carlos Pinto de et al. Characterization of export receptor exportins (XPOs) in the parasite Schistosoma mansoni. Parasitol Res., v. 112, n. 12, p. 4151-4159, 2013.
0932-0113
10.1007/s00436-013-3606-x
url https://www.arca.fiocruz.br/handle/icict/30362
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlang
publisher.none.fl_str_mv Springer Verlang
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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