Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil

Detalhes bibliográficos
Autor(a) principal: Ferreira, Natália S.
Data de Publicação: 2022
Outros Autores: Mathias, Jéssica Lorena S, Albuquerque, Sérgio Roberto L, Almeida, Anne Cristine G, Dantas, Ana C, Anselmo, Fernanda C, Lima, Emerson S, Lacerda, Marcus Vinicius G, Nogueira, Paulo A, Ramasawmy, Rajendranath, Gonçalves, Marilda S, Moura Neto, José P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54887
Resumo: Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
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spelling Ferreira, Natália S.Mathias, Jéssica Lorena SAlbuquerque, Sérgio Roberto LAlmeida, Anne Cristine GDantas, Ana CAnselmo, Fernanda CLima, Emerson SLacerda, Marcus Vinicius GNogueira, Paulo ARamasawmy, RajendranathGonçalves, Marilda SMoura Neto, José P2022-09-27T16:42:14Z2022-09-27T16:42:14Z2022FERREIRA, Natália S. et al. Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil. Malaria Journal, v. 21, n. 144, p. 1-11, 2022.1475-2875https://www.arca.fiocruz.br/handle/icict/5488710.1186/s12936-022-04165-yFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).Universidade do Estado do Amazonas. Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.Universidade Do Estado Do Amazonas. Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.Universidade Do Estado Do Amazonas. Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. / Universidade Nilton Lins. Faculdade de Medicina. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Do Estado Do Amazonas. Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.Background: Over a third of the world’s population is at risk of Plasmodium vivax-induced malaria. The unique aspect of the parasite’s biology and interactions with the human host make it harder to control and eliminate the disease. Glucose-6-phosphate dehydrogenase (G6PD) deficiency and Duffy-negative blood groups are two red blood cell (RBC) variations that can confer protection against malaria. Methods: Molecular genotyping of G6PD and Duffy variants was performed in 225 unrelated patients (97 with uncomplicated and 128 with severe vivax malaria) recruited at a Reference Centre for Infectious Diseases in Manaus. G6PD and Duffy variants characterizations were performed using Real Time PCR (qPCR) and PCR–RFLP, respectively. Results: The Duffy blood group system showed a phenotypic distribution Fy(a + b−) of 70 (31.1%), Fy(a + b +) 96 (42.7%), Fy(a−b +) 56 (24.9%) and Fy(a−b−) 1 (0.44%.) The genotype FY*A/FY*B was predominant in both uncomplicated (45.3%) and severe malaria (39.2%). Only one Duffy phenotype Fy(a-b) was found and this involved uncomplicated vivax malaria. The G6PD c.202G > A variant was found in 11 (4.88%) females and 18 (8.0%) males, while c.376A > G was found in 20 females (8.88%) and 23 (10.22%) male patients. When combined GATA mutated and c.202G > A and c.376A > G mutated, was observed at a lower frequency in uncomplicated (3.7%) in comparison to severe malaria (37.9%). The phenotype Fy(a−b +) (p = 0.022) with FY*B/FY*B (p = 0.015) genotype correlated with higher parasitaemia. Conclusions: A high prevalence of G6PD c202G > A and c.376A > G and Duffy variants is observed in Manaus, an endemic area for vivax malaria. In addition, this study reports for the first time the Duffy null phenotype Fy(a-b-) in the population of the Amazonas state. Moreover, it is understood that the relationship between G6PD and Duffy variants can modify clinical symptoms in malaria caused by P. vivax and this deserves to be further investigated and explored among this population.engBMCMalariaMaláriaG6PDSistema DuffyP. vivaxMalariaG6PDDuffy systemP. vivaxMaláriaSistema do Grupo Sanguíneo DuffyProteína 1 de Superfície de MerozoitoDufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54887/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFerreira, Natália S - Duffy blood system and G6PD genetic.pdfFerreira, Natália S - Duffy blood system and G6PD 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dc.title.en_US.fl_str_mv Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
title Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
spellingShingle Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
Ferreira, Natália S.
Malaria
Malária
G6PD
Sistema Duffy
P. vivax
Malaria
G6PD
Duffy system
P. vivax
Malária
Sistema do Grupo Sanguíneo Duffy
Proteína 1 de Superfície de Merozoito
title_short Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
title_full Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
title_fullStr Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
title_full_unstemmed Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
title_sort Dufy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil
author Ferreira, Natália S.
author_facet Ferreira, Natália S.
Mathias, Jéssica Lorena S
Albuquerque, Sérgio Roberto L
Almeida, Anne Cristine G
Dantas, Ana C
Anselmo, Fernanda C
Lima, Emerson S
Lacerda, Marcus Vinicius G
Nogueira, Paulo A
Ramasawmy, Rajendranath
Gonçalves, Marilda S
Moura Neto, José P
author_role author
author2 Mathias, Jéssica Lorena S
Albuquerque, Sérgio Roberto L
Almeida, Anne Cristine G
Dantas, Ana C
Anselmo, Fernanda C
Lima, Emerson S
Lacerda, Marcus Vinicius G
Nogueira, Paulo A
Ramasawmy, Rajendranath
Gonçalves, Marilda S
Moura Neto, José P
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Natália S.
Mathias, Jéssica Lorena S
Albuquerque, Sérgio Roberto L
Almeida, Anne Cristine G
Dantas, Ana C
Anselmo, Fernanda C
Lima, Emerson S
Lacerda, Marcus Vinicius G
Nogueira, Paulo A
Ramasawmy, Rajendranath
Gonçalves, Marilda S
Moura Neto, José P
dc.subject.mesh.en_US.fl_str_mv Malaria
topic Malaria
Malária
G6PD
Sistema Duffy
P. vivax
Malaria
G6PD
Duffy system
P. vivax
Malária
Sistema do Grupo Sanguíneo Duffy
Proteína 1 de Superfície de Merozoito
dc.subject.other.en_US.fl_str_mv Malária
G6PD
Sistema Duffy
P. vivax
dc.subject.en.en_US.fl_str_mv Malaria
G6PD
Duffy system
P. vivax
dc.subject.decs.en_US.fl_str_mv Malária
Sistema do Grupo Sanguíneo Duffy
Proteína 1 de Superfície de Merozoito
description Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-09-27T16:42:14Z
dc.date.available.fl_str_mv 2022-09-27T16:42:14Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Natália S. et al. Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil. Malaria Journal, v. 21, n. 144, p. 1-11, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54887
dc.identifier.issn.en_US.fl_str_mv 1475-2875
dc.identifier.doi.none.fl_str_mv 10.1186/s12936-022-04165-y
identifier_str_mv FERREIRA, Natália S. et al. Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil. Malaria Journal, v. 21, n. 144, p. 1-11, 2022.
1475-2875
10.1186/s12936-022-04165-y
url https://www.arca.fiocruz.br/handle/icict/54887
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54887/1/license.txt
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