Clinical and epidemiological profile of patients with early stage mycosis fungoides

Detalhes bibliográficos
Autor(a) principal: Amorim, Gustavo Moreira
Data de Publicação: 2018
Outros Autores: Niemeyer-Corbellini, João Paulo, Quintella, Danielle Carvalho, Cuzzi, Tullia, Ramos-e-Silva, Márcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31141
Resumo: Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade do Sul de Santa Catarina. Faculdade de Medicina. Dermatology Outpatient Clinic. Palhoça, SC, Brasil.
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spelling Amorim, Gustavo MoreiraNiemeyer-Corbellini, João PauloQuintella, Danielle CarvalhoCuzzi, TulliaRamos-e-Silva, Márcia2019-01-18T13:55:23Z2019-01-18T13:55:23Z2018AMORIM, Gustavo Moreira et al. Clinical and epidemiological profile of patients with early stage mycosis fungoides. Anais Brasileiros de Dermatologia, v. 93, n. 4, p. 546-552, 2018.0365-0596https://www.arca.fiocruz.br/handle/icict/3114110.1590/abd1806-4841.20187106engSociedade Brasileira de DermatologiaClinical and epidemiological profile of patients with early stage mycosis fungoidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade do Sul de Santa Catarina. Faculdade de Medicina. Dermatology Outpatient Clinic. Palhoça, SC, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Dermatology Service. Rio de Janeiro, RJ, Brasil.Hospital Federal de Bonsucesso. Pathology Service. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Department of Pathology. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Department of Pathology. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Dermatology Service. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Discipline of Dermatology. Rio de Janeiro, RJ, Brasil.Background: Mycosis fungoides is the most common form of primary cutaneous lymphoma, with an indolent, slowly progressive course and 88% five-year survival rate. The diagnosis is challenging, especially in the early stages, and usually relies on a good clinical-histopathological correlation. Objective: The aim was to establish the clinical and epidemiological profile of patients with early-stage mycosis fungoides. Methods: This was a retrospective cross-sectional observational study with an exploratory analysis. Outcome variables were disease progression and mycosis fungoides-related death. Results: One hundred and two patients were included. The majority were white males, with a mean age of 55.6 years. Mean time from onset of lesions to diagnosis was 51.08 months. The majority of patients were classified as IB stage according to TNMB. Mean follow-up time was 7.85 years. Disease progression was seen in 29.4% of the patients. Death related to the disease occurred in 7.9% of patients. Plaque lesions, involvement of more than 10% of the body surface, altered lactate dehydrogenase and beta-2-microglobulin, and stage IB were significantly associated with disease progression, and altered lactate dehydrogenase and beta-2-microglobulin also correlated with higher frequency of deaths. Study limitations: Small sample and retrospective design. Conclusions: The clinical and epidemiological profile of patients with early-stage mycosis fungoides in our sample corroborates reports in the literature. Diagnostic delay in our series is also consistent with previous findings, but the rate of disease progression, despite treatment, was higher than reported in the literature.LymphomaLymphoma T-cell cutaneousMycosis fungoidesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/31141/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Amorim_Gustavo_etal_INI_2018.pdfve_Amorim_Gustavo_etal_INI_2018.pdfapplication/pdf325079https://www.arca.fiocruz.br/bitstream/icict/31141/2/ve_Amorim_Gustavo_etal_INI_2018.pdf8c29b749f0933cfaa67ee8ccafb06185MD52TEXTve_Amorim_Gustavo_etal_INI_2018.pdf.txtve_Amorim_Gustavo_etal_INI_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Clinical and epidemiological profile of patients with early stage mycosis fungoides
title Clinical and epidemiological profile of patients with early stage mycosis fungoides
spellingShingle Clinical and epidemiological profile of patients with early stage mycosis fungoides
Amorim, Gustavo Moreira
Lymphoma
Lymphoma T-cell cutaneous
Mycosis fungoides
title_short Clinical and epidemiological profile of patients with early stage mycosis fungoides
title_full Clinical and epidemiological profile of patients with early stage mycosis fungoides
title_fullStr Clinical and epidemiological profile of patients with early stage mycosis fungoides
title_full_unstemmed Clinical and epidemiological profile of patients with early stage mycosis fungoides
title_sort Clinical and epidemiological profile of patients with early stage mycosis fungoides
author Amorim, Gustavo Moreira
author_facet Amorim, Gustavo Moreira
Niemeyer-Corbellini, João Paulo
Quintella, Danielle Carvalho
Cuzzi, Tullia
Ramos-e-Silva, Márcia
author_role author
author2 Niemeyer-Corbellini, João Paulo
Quintella, Danielle Carvalho
Cuzzi, Tullia
Ramos-e-Silva, Márcia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Amorim, Gustavo Moreira
Niemeyer-Corbellini, João Paulo
Quintella, Danielle Carvalho
Cuzzi, Tullia
Ramos-e-Silva, Márcia
dc.subject.en.pt_BR.fl_str_mv Lymphoma
Lymphoma T-cell cutaneous
Mycosis fungoides
topic Lymphoma
Lymphoma T-cell cutaneous
Mycosis fungoides
description Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade do Sul de Santa Catarina. Faculdade de Medicina. Dermatology Outpatient Clinic. Palhoça, SC, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-18T13:55:23Z
dc.date.available.fl_str_mv 2019-01-18T13:55:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AMORIM, Gustavo Moreira et al. Clinical and epidemiological profile of patients with early stage mycosis fungoides. Anais Brasileiros de Dermatologia, v. 93, n. 4, p. 546-552, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31141
dc.identifier.issn.pt_BR.fl_str_mv 0365-0596
dc.identifier.doi.none.fl_str_mv 10.1590/abd1806-4841.20187106
identifier_str_mv AMORIM, Gustavo Moreira et al. Clinical and epidemiological profile of patients with early stage mycosis fungoides. Anais Brasileiros de Dermatologia, v. 93, n. 4, p. 546-552, 2018.
0365-0596
10.1590/abd1806-4841.20187106
url https://www.arca.fiocruz.br/handle/icict/31141
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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