Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19295 |
Resumo: | Programa de Doutorado da Rede Nordeste de Biotecnologia. Recife, PE, Brasil. |
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Belmont, Taciana Furtado de MendonçaÓ, Kleyton Palmeira doSilva, Andreia Soares daVilar, Kamila de MeloMedeiros, Fernanda SilvaVasconcelos, Luydson Richardson SilvaAnjos, Ana Claudia Mendonça DosHatzlhofer, Betânia Lucena DominguesPitta, Maíra Galdino da RochaBezerra, Marcos André CavalcantiAraújo, Aderson da SilvaRego, Moacyr Jesus Barreto de MeloMoura, PatríciaCavalcanti, Maria do Socorro Mendonça2017-06-05T13:08:29Z2017-06-05T13:08:29Z2016BELMONT, T. F. de Mendonça et al. Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia. PLOS ONE, v. 11, n. 9, p. e0162297, 7 set. 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1929510.1371/journal.pone.0162297engSingle Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePrograma de Doutorado da Rede Nordeste de Biotecnologia. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas e Faculdade de Ciências Médicas. Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas e Faculdade de Ciências Médicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Laboratório de Imunomodulação e Novas Abordagens Terapêutica (LINAT). Recife, PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas e Faculdade de Ciências Médicas. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Hematologia e Hemoterapia de Pernambuco (HEMOPE). Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Ciências Biológicas. Recife, PE, Brasil.Universidade Federal de Pernambuco. Laboratório de Imunomodulação e Novas Abordagens Terapêutica (LINAT). Recife, PE, Brasil.Universidade Federal de Pernambuco. Departamento de Ciências Biológicas. Recife, PE, Brasil.Fundação Hematologia e Hemoterapia de Pernambuco (HEMOPE). Recife, PE, Brasil.Universidade Federal de Pernambuco. Laboratório de Imunomodulação e Novas Abordagens Terapêutica (LINAT). Recife, PE, Brasil.Programa de Doutorado da Rede Nordeste de Biotecnologia. Recife, PE, Brasil / Universidade de Pernambuco. Instituto de Ciências Biológicas e Faculdade de Ciências Médicas. Recife, PE, Brasil.Programa de Doutorado da Rede Nordeste de Biotecnologia. Recife, PE, Brasil / Universidade de Pernambuco. Instituto de Ciências Biológicas e Faculdade de Ciências Médicas. Recife, PE, Brasil.Patients with sickle cell anemia (SCA) may present chronic hemolytic anemia, vaso-occlusion and respiratory tract infection (RTI) episodes. Galectin-3 (GAL-3) is a multifunctional protein involved in inflammation, apoptosis, adhesion and resistance to reactive oxygen species. Studies point to a dual role for GAL-3 as both a circulation damage-associated molecular pattern and a cell membrane associated pattern recognition receptor.Anemia Falciforme / sangueAnemia Falciforme / genéticaVasos Sanguíneos / PatologiaGalectina 3 / sangueGalectina 3 / genéticaPolimorfismo de Nucleotídeo Único / genéticaInfecções Respiratórias / sangueInfecções Respiratórias / genéticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19295/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL27603703 2016 men-sin.oa.PDF27603703 2016 men-sin.oa.PDFapplication/pdf1008770https://www.arca.fiocruz.br/bitstream/icict/19295/2/27603703%202016%20men-sin.oa.PDF82f0081628ade062bc08ce6be5782a03MD52TEXT27603703 2016 men-sin.oa.PDF.txt27603703 2016 men-sin.oa.PDF.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia |
| title |
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia |
| spellingShingle |
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia Belmont, Taciana Furtado de Mendonça Anemia Falciforme / sangue Anemia Falciforme / genética Vasos Sanguíneos / Patologia Galectina 3 / sangue Galectina 3 / genética Polimorfismo de Nucleotídeo Único / genética Infecções Respiratórias / sangue Infecções Respiratórias / genética |
| title_short |
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia |
| title_full |
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia |
| title_fullStr |
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia |
| title_full_unstemmed |
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia |
| title_sort |
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia |
| author |
Belmont, Taciana Furtado de Mendonça |
| author_facet |
Belmont, Taciana Furtado de Mendonça Ó, Kleyton Palmeira do Silva, Andreia Soares da Vilar, Kamila de Melo Medeiros, Fernanda Silva Vasconcelos, Luydson Richardson Silva Anjos, Ana Claudia Mendonça Dos Hatzlhofer, Betânia Lucena Domingues Pitta, Maíra Galdino da Rocha Bezerra, Marcos André Cavalcanti Araújo, Aderson da Silva Rego, Moacyr Jesus Barreto de Melo Moura, Patrícia Cavalcanti, Maria do Socorro Mendonça |
| author_role |
author |
| author2 |
Ó, Kleyton Palmeira do Silva, Andreia Soares da Vilar, Kamila de Melo Medeiros, Fernanda Silva Vasconcelos, Luydson Richardson Silva Anjos, Ana Claudia Mendonça Dos Hatzlhofer, Betânia Lucena Domingues Pitta, Maíra Galdino da Rocha Bezerra, Marcos André Cavalcanti Araújo, Aderson da Silva Rego, Moacyr Jesus Barreto de Melo Moura, Patrícia Cavalcanti, Maria do Socorro Mendonça |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Belmont, Taciana Furtado de Mendonça Ó, Kleyton Palmeira do Silva, Andreia Soares da Vilar, Kamila de Melo Medeiros, Fernanda Silva Vasconcelos, Luydson Richardson Silva Anjos, Ana Claudia Mendonça Dos Hatzlhofer, Betânia Lucena Domingues Pitta, Maíra Galdino da Rocha Bezerra, Marcos André Cavalcanti Araújo, Aderson da Silva Rego, Moacyr Jesus Barreto de Melo Moura, Patrícia Cavalcanti, Maria do Socorro Mendonça |
| dc.subject.decs.none.fl_str_mv |
Anemia Falciforme / sangue Anemia Falciforme / genética Vasos Sanguíneos / Patologia Galectina 3 / sangue Galectina 3 / genética Polimorfismo de Nucleotídeo Único / genética Infecções Respiratórias / sangue Infecções Respiratórias / genética |
| topic |
Anemia Falciforme / sangue Anemia Falciforme / genética Vasos Sanguíneos / Patologia Galectina 3 / sangue Galectina 3 / genética Polimorfismo de Nucleotídeo Único / genética Infecções Respiratórias / sangue Infecções Respiratórias / genética |
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Programa de Doutorado da Rede Nordeste de Biotecnologia. Recife, PE, Brasil. |
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2016 |
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2016 |
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2017-06-05T13:08:29Z |
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BELMONT, T. F. de Mendonça et al. Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia. PLOS ONE, v. 11, n. 9, p. e0162297, 7 set. 2016. |
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https://www.arca.fiocruz.br/handle/icict/19295 |
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1932-6203 |
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10.1371/journal.pone.0162297 |
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BELMONT, T. F. de Mendonça et al. Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia. PLOS ONE, v. 11, n. 9, p. e0162297, 7 set. 2016. 1932-6203 10.1371/journal.pone.0162297 |
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