Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone

Detalhes bibliográficos
Autor(a) principal: Diaz, Bruno L.
Data de Publicação: 1997
Outros Autores: Serra, Magda F., Barreto, Emiliano O., Cordeiro, Renato S. B., Martins, Marco A., Silva, Patrícia M. R. e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43916
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
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spelling Diaz, Bruno L.Serra, Magda F.Barreto, Emiliano O.Cordeiro, Renato S. B.Martins, Marco A.Silva, Patrícia M. R. e2020-10-10T13:10:32Z2020-10-10T13:10:32Z1997DIAZ, Bruno L. et al. Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormones. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p. 219-222, 1997.0074-0276https://www.arca.fiocruz.br/handle/icict/4391610.1590/S0074-027619970008000311678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.DiabetesPleurisia alérgicaMastócitosEosinophilsCorticosteróidesDiabetesAllergic pleurisyMast cellsEosinophilsCorticosteroidsAntigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormoneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Previous studies have evidenced for the existence of interactive regulatory mechanisms between insulin and steroid hormones in different systems. In this study, we have investigated whether endogenous corticosteroids could be implicated in the hyporeactivity to antigen challenge observed in sensitized diabetic rats. Alloxinated rats showed a long-lasting increase in the blood glucose levels and a reduction in the number of pleural mast cells at 48 and 72 hr, but not at 24 hr after alloxan administration. In parallel, they also showed a significant elevation in the plasma levels of corticosterone together with an increase in the adrenal/body weight ratio. Antigen-evoked eosinophil accumulation appeared significantly reduced in rats pretreated with dexamethasone as well as in those rendered diabetic 72 hr after alloxan. In the same way, naive animals treated with dexamethasone also responded with a significant decrease in the number of pleural mast cells. Interestingly, when sensitized diabetic rats were pretreated with the steroid antagonist RU 38486 a reversion of the reduction in the allergen-induced eosinophil accumulation was noted. We conclude that the down-regulation of the allergic inflammatory response in diabetic rats is close-related to reduction in mast cell numbers and over expression of endogenous corticosteroids.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43916/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBrunoDiaz_MagdaSerra_etal_IOC_1997.pdfBrunoDiaz_MagdaSerra_etal_IOC_1997.pdfapplication/pdf106741https://www.arca.fiocruz.br/bitstream/icict/43916/2/BrunoDiaz_MagdaSerra_etal_IOC_1997.pdf39b44671f872ff29c1f8cf7cf01b5f0aMD52TEXTBrunoDiaz_MagdaSerra_etal_IOC_1997.pdf.txtBrunoDiaz_MagdaSerra_etal_IOC_1997.pdf.txtExtracted texttext/plain17367https://www.arca.fiocruz.br/bitstream/icict/43916/3/BrunoDiaz_MagdaSerra_etal_IOC_1997.pdf.txtf1d080e817626aa8c3744f3ed05a9a5cMD53icict/439162020-10-11 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dc.title.pt_BR.fl_str_mv Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone
title Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone
spellingShingle Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone
Diaz, Bruno L.
Diabetes
Pleurisia alérgica
Mastócitos
Eosinophils
Corticosteróides
Diabetes
Allergic pleurisy
Mast cells
Eosinophils
Corticosteroids
title_short Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone
title_full Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone
title_fullStr Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone
title_full_unstemmed Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone
title_sort Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormone
author Diaz, Bruno L.
author_facet Diaz, Bruno L.
Serra, Magda F.
Barreto, Emiliano O.
Cordeiro, Renato S. B.
Martins, Marco A.
Silva, Patrícia M. R. e
author_role author
author2 Serra, Magda F.
Barreto, Emiliano O.
Cordeiro, Renato S. B.
Martins, Marco A.
Silva, Patrícia M. R. e
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Diaz, Bruno L.
Serra, Magda F.
Barreto, Emiliano O.
Cordeiro, Renato S. B.
Martins, Marco A.
Silva, Patrícia M. R. e
dc.subject.other.pt_BR.fl_str_mv Diabetes
Pleurisia alérgica
Mastócitos
Eosinophils
Corticosteróides
topic Diabetes
Pleurisia alérgica
Mastócitos
Eosinophils
Corticosteróides
Diabetes
Allergic pleurisy
Mast cells
Eosinophils
Corticosteroids
dc.subject.en.pt_BR.fl_str_mv Diabetes
Allergic pleurisy
Mast cells
Eosinophils
Corticosteroids
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2020-10-10T13:10:32Z
dc.date.available.fl_str_mv 2020-10-10T13:10:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DIAZ, Bruno L. et al. Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormones. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p. 219-222, 1997.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43916
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761997000800031
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv DIAZ, Bruno L. et al. Antigen-induced Pleural Eosinophilia is Suppressed in Diabetic Rats: Role of Corticosteroid Hormones. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p. 219-222, 1997.
0074-0276
10.1590/S0074-02761997000800031
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43916
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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