COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil

Bibliographic Details
Main Author: Castro, Rodolfo
Publication Date: 2020
Other Authors: Luz, Paula M., Wakimoto, Mayumi D., Veloso, Valdiléa G., Grinsztejn, Beatriz, Perazzo, Hugo
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/40983
Summary: The authors declare no conflict of interest.
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spelling Castro, RodolfoLuz, Paula M.Wakimoto, Mayumi D.Veloso, Valdiléa G.Grinsztejn, BeatrizPerazzo, Hugo2020-04-27T14:53:44Z2020-04-27T14:53:44Z2020CASTRO, Rodolfo et al. COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil. The Brazilian Journal of Infectious Diseases, v. 968, p. 1-8, 2020.1413-8670https://www.arca.fiocruz.br/handle/icict/4098310.1016/j.bjid.2020.04.0031678-4391The authors declare no conflict of interest.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Instituto de Saúde Coletiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.The accuracy of commercially available tests for COVID-19 in Brazil remains unclear. We aimed to perform a meta-analysis to describe the accuracy of available tests to detect COVID19 in Brazil.We searched atthe Brazilian Health Regulatory Agency (ANVISA) online platform to describe the pooled sensitivity (Se), specificity (Sp), diagnostic odds ratio (DOR) and summary receiver operating characteristic curves (SROC) for detection of IgM/IgG antibodies and for tests using naso/oropharyngeal swabs in the random-effects models. We identified 16 tests registered, mostly rapid-tests. Pooled diagnostic accuracy measures [95%CI] were: (i) for IgM antibodies Se = 82% [76–87]; Sp = 97% [96–98]; DOR = 168 [92–305] and SROC= 0.98 [0.96–0.99]; (ii) for IgG antibodies Se = 97% [90–99]; Sp = 98% [97–99]; DOR = 1994 [385–10334] and SROC= 0.99 [0.98–1.00]; and (iii) for detection of SARS-CoV-2 by antigen or molecular assays in naso/oropharyngeal swabs Se = 97% [85–99]; Sp = 99% [77–100]; DOR = 2649 [30–233056] and SROC= 0.99 [0.98–1.00]. These tests can be helpful for emergency testing during the COVID-19 pandemic in Brazil. However, it is important to highlight the high rate of false negative results from tests which detect SARS-CoV-2 IgM antibodies in the initial course of the disease and the scarce evidence-based validation results published in Brazil. Future studies addressing the diagnostic performance of tests for COVID-19 in the Brazilian population are urgently needed.engElsevierCoronavirus InfectionsSARS-CoV-2CoronavirusCOVID-19Diagnostic accuracyCoronavirus InfectionsCOVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
title COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
spellingShingle COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
Castro, Rodolfo
Coronavirus Infections
SARS-CoV-2
Coronavirus
COVID-19
Diagnostic accuracy
Coronavirus Infections
title_short COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
title_full COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
title_fullStr COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
title_full_unstemmed COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
title_sort COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil
author Castro, Rodolfo
author_facet Castro, Rodolfo
Luz, Paula M.
Wakimoto, Mayumi D.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Perazzo, Hugo
author_role author
author2 Luz, Paula M.
Wakimoto, Mayumi D.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Perazzo, Hugo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Rodolfo
Luz, Paula M.
Wakimoto, Mayumi D.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Perazzo, Hugo
dc.subject.mesh.pt_BR.fl_str_mv Coronavirus Infections
topic Coronavirus Infections
SARS-CoV-2
Coronavirus
COVID-19
Diagnostic accuracy
Coronavirus Infections
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
Coronavirus
COVID-19
Diagnostic accuracy
dc.subject.decs.pt_BR.fl_str_mv Coronavirus Infections
description The authors declare no conflict of interest.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-04-27T14:53:44Z
dc.date.available.fl_str_mv 2020-04-27T14:53:44Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTRO, Rodolfo et al. COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil. The Brazilian Journal of Infectious Diseases, v. 968, p. 1-8, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40983
dc.identifier.issn.pt_BR.fl_str_mv 1413-8670
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.bjid.2020.04.003
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv CASTRO, Rodolfo et al. COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil. The Brazilian Journal of Infectious Diseases, v. 968, p. 1-8, 2020.
1413-8670
10.1016/j.bjid.2020.04.003
1678-4391
url https://www.arca.fiocruz.br/handle/icict/40983
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40983/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/40983/2/Castro_Rodolfo_et_al_INI_ENSP_2020.pdf
https://www.arca.fiocruz.br/bitstream/icict/40983/3/Castro_Rodolfo_et_al_INI_ENSP_2020.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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