Left atrial and left ventricular diastolic function in chronic Chagas disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35727 |
Resumo: | 2020-09-20 |
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Nascimento, Cesar Augusto S.Gomes, Victor Augusto M.Silva, Sabrina K.Santos, Carla Renata F.Chambela, Mayara C.Madeira, Fabiana S.Holanda, Marcelo T.Brasil, Pedro Emmanuel A. A.Sousa, Andrea S.Xavier, Sergio S.Hasslocher-Moreno, Alejandro MarcelCunha, Ademir B.Saraiva, Roberto M.2019-09-20T14:43:20Z2019-09-20T14:43:20Z2013NASCIMENTO, Cesar Augusto S. et al. Left atrial and left ventricular diastolic function in chronic Chagas disease. Journal of the American Society of Echocardiography, v. 26, n. 12, p. 1424-1433, Dec. 2013.0894-7317https://www.arca.fiocruz.br/handle/icict/3572710.1016/j.echo.2013.08.0181097-6795engElsevierLeft atrial and left ventricular diastolic function in chronic Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-09-20Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background: Left atrial (LA) and left ventricular (LV) diastolic function analysis can yield new strategies to recognize early cardiac involvement and prognostic indicators in Chagas disease. Methods: Patients with Chagas disease with the indeterminate (n= 69) or with the cardiac form (32 with changes limited to electrocardiography [stage A], 25 with changes in LV systolic function but no heart failure [HF; stage B], and 26 with HF) underwent evaluation of LV diastolic function (mitral inflow, pulmonary vein flow,color M-mode echocardiography, and tissue Doppler analysis), and LA function by three-dimensional echocardiography and strain analysis and were prospectively followed for the occurrence of clinical events. Echocardiograms were also obtained from 32 controls. Results: LV diastolic dysfunction was gradually more prevalent and severe across groups from patients with the indeterminate form of Chagas disease to patients with HF. Tissue Doppler was the best tool to demonstrate the worsening of LV diastolic function across the groups (E' velocity: controls, 12.662.3 cm/sec;patients with the indeterminate form, 12.163.1 cm/sec; stage A, 10.362.9 cm/sec; stage B, 8.362.8 cm/sec; patients with HF, 5.661.9;P< .0001). Although maximum LA volume was increased only in pa-tients with HF, minimum LA volume (controls, 862 mL/m2; patients with the indeterminate form, 862 mL/m2; stage A, 963 mL/m2; stage B, 1164 mL/m2; patients with HF, 27617 mL/m2;P< .0001) and precontraction LA volume (controls, 1163 mL/m2; patients with the indeterminate form, 1263 mL/m2; stage A, 1364 mL/m2; stage B, 1665 mL/m2; patients with HF, 32619 mL/m2;P< .0001) were increased in all cardiacform groups. LA conductive function was depressed in all cardiac form groups, while LA contractile functionwas depressed only in patients with HF. Cox proportional-hazards regression analysis revealed that end-systolic LV diameter (hazard ratio, 1.6; 95% confidence interval, 0.9–2.8;P= .09), E' velocity (hazard ratio,0.5; 95% confidence interval, 0.3–0.8;P= .001), and peak negative global LA strain (hazard ratio, 1.21;95% confidence interval, 1.02–1.4;P= .03), were independent predictors of clinical events.Conclusions:LV diastolic dysfunction was found in all forms of chronic Chagas disease, including those without LV systolic dysfunction. LV diastolic dysfunction may contribute to changes in LA volume and conductive function found in early stages of the cardiac form. Both LV diastolic function and LA contractile function were independent predictors of clinical events.Two-dimensional strainLeft atrial functionLeft ventricular diastolic functionReal-time three-dimensional echocardiographyChagas diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35727/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Nascimento_cesar_etal_INI_2013.pdfve_Nascimento_cesar_etal_INI_2013.pdfapplication/pdf655968https://www.arca.fiocruz.br/bitstream/icict/35727/2/ve_Nascimento_cesar_etal_INI_2013.pdfea1df233e7cf00d758cfac3533aeb58bMD52TEXTve_Nascimento_cesar_etal_INI_2013.pdf.txtve_Nascimento_cesar_etal_INI_2013.pdf.txtExtracted texttext/plain52543https://www.arca.fiocruz.br/bitstream/icict/35727/3/ve_Nascimento_cesar_etal_INI_2013.pdf.txt551c7c57246ddff763efeed6da50743aMD53icict/357272023-03-08 09:43:50.493oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-08T12:43:50Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Left atrial and left ventricular diastolic function in chronic Chagas disease |
| title |
Left atrial and left ventricular diastolic function in chronic Chagas disease |
| spellingShingle |
Left atrial and left ventricular diastolic function in chronic Chagas disease Nascimento, Cesar Augusto S. Two-dimensional strain Left atrial function Left ventricular diastolic function Real-time three-dimensional echocardiography Chagas disease |
| title_short |
Left atrial and left ventricular diastolic function in chronic Chagas disease |
| title_full |
Left atrial and left ventricular diastolic function in chronic Chagas disease |
| title_fullStr |
Left atrial and left ventricular diastolic function in chronic Chagas disease |
| title_full_unstemmed |
Left atrial and left ventricular diastolic function in chronic Chagas disease |
| title_sort |
Left atrial and left ventricular diastolic function in chronic Chagas disease |
| author |
Nascimento, Cesar Augusto S. |
| author_facet |
Nascimento, Cesar Augusto S. Gomes, Victor Augusto M. Silva, Sabrina K. Santos, Carla Renata F. Chambela, Mayara C. Madeira, Fabiana S. Holanda, Marcelo T. Brasil, Pedro Emmanuel A. A. Sousa, Andrea S. Xavier, Sergio S. Hasslocher-Moreno, Alejandro Marcel Cunha, Ademir B. Saraiva, Roberto M. |
| author_role |
author |
| author2 |
Gomes, Victor Augusto M. Silva, Sabrina K. Santos, Carla Renata F. Chambela, Mayara C. Madeira, Fabiana S. Holanda, Marcelo T. Brasil, Pedro Emmanuel A. A. Sousa, Andrea S. Xavier, Sergio S. Hasslocher-Moreno, Alejandro Marcel Cunha, Ademir B. Saraiva, Roberto M. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nascimento, Cesar Augusto S. Gomes, Victor Augusto M. Silva, Sabrina K. Santos, Carla Renata F. Chambela, Mayara C. Madeira, Fabiana S. Holanda, Marcelo T. Brasil, Pedro Emmanuel A. A. Sousa, Andrea S. Xavier, Sergio S. Hasslocher-Moreno, Alejandro Marcel Cunha, Ademir B. Saraiva, Roberto M. |
| dc.subject.en.pt_BR.fl_str_mv |
Two-dimensional strain Left atrial function Left ventricular diastolic function Real-time three-dimensional echocardiography Chagas disease |
| topic |
Two-dimensional strain Left atrial function Left ventricular diastolic function Real-time three-dimensional echocardiography Chagas disease |
| description |
2020-09-20 |
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2013 |
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2013 |
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2019-09-20T14:43:20Z |
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2019-09-20T14:43:20Z |
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info:eu-repo/semantics/article |
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NASCIMENTO, Cesar Augusto S. et al. Left atrial and left ventricular diastolic function in chronic Chagas disease. Journal of the American Society of Echocardiography, v. 26, n. 12, p. 1424-1433, Dec. 2013. |
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https://www.arca.fiocruz.br/handle/icict/35727 |
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0894-7317 |
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10.1016/j.echo.2013.08.018 |
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1097-6795 |
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NASCIMENTO, Cesar Augusto S. et al. Left atrial and left ventricular diastolic function in chronic Chagas disease. Journal of the American Society of Echocardiography, v. 26, n. 12, p. 1424-1433, Dec. 2013. 0894-7317 10.1016/j.echo.2013.08.018 1097-6795 |
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Elsevier |
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