Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/52463 |
Resumo: | Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. |
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Miyasaki, Dayane MayumiSenegaglia, Alexandra CristinaMoura, Sérgio Adriane Bezerra deLeitolis, AmandaCapriglione, Luiz Guilherme AchcarFracaro, LetíciaLeite, Lidiane Maria BoldriniUtumi, Paulo HenriqueFragoso, Felipe Yukio IshikawaMeyer, FernandoCorrea, AlejandroBrofman, Paulo Roberto Slud2022-04-29T18:13:45Z2022-04-29T18:13:45Z2022MIYASAKI, Dayane Mayumi et al. Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: a comparative preclinical analysis. Scientific Reports, v. 23, n. 2521, p. 1–20, 2022.1422-0067https://www.arca.fiocruz.br/handle/icict/5246310.3390/ijms23052521porMDPITreatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil.Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Norte. Campus Universitário Lagoa Nova. Departamento de Morfologia. Natal, RN, Brasil.Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil.Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil.Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil.Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil.Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil.Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil.Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil.Chronic kidney disease (CKD) is characterized by structural abnormalities and the progressive loss of kidney function. Extracellular vesicles (EVs) from human umbilical cord tissue (hUCT)-derived mesenchymal stem cells (MSCs) and expanded human umbilical cord blood (hUCB)- derived CD133+ cells (eCD133+ ) maintain the characteristics of the parent cells, providing a new form of cell-free treatment. We evaluated the effects of EVs from hUCT-derived MSCs and hUCB-derived CD133+ cells on rats with CDK induced by an adenine-enriched diet. EVs were isolated by ultracentrifugation and characterized by nanoparticle tracking analysis (NTA) and electron microscopy. The animals were randomized and divided into the MSC-EV group, eEPC-EV group and control group. Infusions occurred on the seventh and 14th days after CKD induction. Evaluations of kidney function were carried out by biochemical and histological analyses. Intense labeling of the α-SMA protein was observed when comparing the control with MSC-EVs. In both groups treated with EVs, a significant increase in serum albumin was observed, and the increase in cystatin C was inhibited. The results indicated improvements in renal function in CKD, demonstrating the therapeutic potential of EVs derived from MSCs and eCD133+ cells and suggesting the possibility that in the future, more than one type of EV will be used concurrently.Chronic Kidney DiseaseExtracellular VesiclesMesenchymal Stem CellsEndothelial Progenitor CellsAdenineFallo Renal CrónicoVesículas ExtracelularesCélulas Madre MesenquimatosasCélulas Progenitoras EndotelialesAdeninaDéfaillance rénale chroniqueVésicules extracellulairesCellules souches mésenchymateusesProgéniteurs endothéliauxAdénineFalência Renal CrônicaVesículas ExtracelularesCélulas-Tronco MesenquimaisCélulas Progenitoras EndoteliaisAdeninainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis |
title |
Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis |
spellingShingle |
Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis Miyasaki, Dayane Mayumi Chronic Kidney Disease Extracellular Vesicles Mesenchymal Stem Cells Endothelial Progenitor Cells Adenine Fallo Renal Crónico Vesículas Extracelulares Células Madre Mesenquimatosas Células Progenitoras Endoteliales Adenina Défaillance rénale chronique Vésicules extracellulaires Cellules souches mésenchymateuses Progéniteurs endothéliaux Adénine Falência Renal Crônica Vesículas Extracelulares Células-Tronco Mesenquimais Células Progenitoras Endoteliais Adenina |
title_short |
Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis |
title_full |
Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis |
title_fullStr |
Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis |
title_full_unstemmed |
Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis |
title_sort |
Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: A comparative preclinical analysis |
author |
Miyasaki, Dayane Mayumi |
author_facet |
Miyasaki, Dayane Mayumi Senegaglia, Alexandra Cristina Moura, Sérgio Adriane Bezerra de Leitolis, Amanda Capriglione, Luiz Guilherme Achcar Fracaro, Letícia Leite, Lidiane Maria Boldrini Utumi, Paulo Henrique Fragoso, Felipe Yukio Ishikawa Meyer, Fernando Correa, Alejandro Brofman, Paulo Roberto Slud |
author_role |
author |
author2 |
Senegaglia, Alexandra Cristina Moura, Sérgio Adriane Bezerra de Leitolis, Amanda Capriglione, Luiz Guilherme Achcar Fracaro, Letícia Leite, Lidiane Maria Boldrini Utumi, Paulo Henrique Fragoso, Felipe Yukio Ishikawa Meyer, Fernando Correa, Alejandro Brofman, Paulo Roberto Slud |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Miyasaki, Dayane Mayumi Senegaglia, Alexandra Cristina Moura, Sérgio Adriane Bezerra de Leitolis, Amanda Capriglione, Luiz Guilherme Achcar Fracaro, Letícia Leite, Lidiane Maria Boldrini Utumi, Paulo Henrique Fragoso, Felipe Yukio Ishikawa Meyer, Fernando Correa, Alejandro Brofman, Paulo Roberto Slud |
dc.subject.en.pt_BR.fl_str_mv |
Chronic Kidney Disease Extracellular Vesicles Mesenchymal Stem Cells Endothelial Progenitor Cells Adenine |
topic |
Chronic Kidney Disease Extracellular Vesicles Mesenchymal Stem Cells Endothelial Progenitor Cells Adenine Fallo Renal Crónico Vesículas Extracelulares Células Madre Mesenquimatosas Células Progenitoras Endoteliales Adenina Défaillance rénale chronique Vésicules extracellulaires Cellules souches mésenchymateuses Progéniteurs endothéliaux Adénine Falência Renal Crônica Vesículas Extracelulares Células-Tronco Mesenquimais Células Progenitoras Endoteliais Adenina |
dc.subject.es.pt_BR.fl_str_mv |
Fallo Renal Crónico Vesículas Extracelulares Células Madre Mesenquimatosas Células Progenitoras Endoteliales Adenina |
dc.subject.fr.pt_BR.fl_str_mv |
Défaillance rénale chronique Vésicules extracellulaires Cellules souches mésenchymateuses Progéniteurs endothéliaux Adénine |
dc.subject.decs.pt_BR.fl_str_mv |
Falência Renal Crônica Vesículas Extracelulares Células-Tronco Mesenquimais Células Progenitoras Endoteliais Adenina |
description |
Pontificia Universidade Católica do Paraná. Faculdade de Medicina. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-04-29T18:13:45Z |
dc.date.available.fl_str_mv |
2022-04-29T18:13:45Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MIYASAKI, Dayane Mayumi et al. Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: a comparative preclinical analysis. Scientific Reports, v. 23, n. 2521, p. 1–20, 2022. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/52463 |
dc.identifier.issn.pt_BR.fl_str_mv |
1422-0067 |
dc.identifier.doi.none.fl_str_mv |
10.3390/ijms23052521 |
identifier_str_mv |
MIYASAKI, Dayane Mayumi et al. Treatment of chronic kidney disease with extracellular vesicles from mesenchymal stem cells and CD133+ expanded cells: a comparative preclinical analysis. Scientific Reports, v. 23, n. 2521, p. 1–20, 2022. 1422-0067 10.3390/ijms23052521 |
url |
https://www.arca.fiocruz.br/handle/icict/52463 |
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por |
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openAccess |
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MDPI |
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MDPI |
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