Current status of mesenchymal stem/stromal cells for treatment of neurological diseases

Detalhes bibliográficos
Autor(a) principal: Soares, Milena B. P
Data de Publicação: 2022
Outros Autores: Gonçalves, Renata G. J, Vasques, Juliana F, Silva Junior, Almir J. da, Gubert, Fernanda, Santos, Girlaine Café, Santana, Thaís Alves de, Sampaio, Gabriela Louise Almeida, Silva, Daniela Nascimento, Dominici, Massimo, Otero, Rosalia Mendez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55140
Resumo: Departamento de Ciência e Tecnologia (DECIT/MS) do Ministério da Saúde. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
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spelling Soares, Milena B. PGonçalves, Renata G. JVasques, Juliana FSilva Junior, Almir J. daGubert, FernandaSantos, Girlaine CaféSantana, Thaís Alves deSampaio, Gabriela Louise AlmeidaSilva, Daniela NascimentoDominici, MassimoOtero, Rosalia Mendez2022-10-14T14:31:24Z2022-10-14T14:31:24Z2022SOARES, Milena B. P. et al. Current status of mesenchymal stem/stromal cells for treatment of neurological diseases. Frontiers in Molecular Neuroscience, v. 15, p. 1-36, 2022.1662-5099https://www.arca.fiocruz.br/handle/icict/5514010.3389/fnmol.2022.883378Departamento de Ciência e Tecnologia (DECIT/MS) do Ministério da Saúde. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Instituto SENAI de Sistemas Avançados de Saúde (CIMATEC ISI-SAS). Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Neurobiologia Celular e Molecular. Rio de Janeiro, RJ, Brasil / Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Neurobiologia Celular e Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Neurobiologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Instituto SENAI de Sistemas Avançados de Saúde (CIMATEC ISI-SAS). Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Instituto SENAI de Sistemas Avançados de Saúde (CIMATEC ISI-SAS). Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil / Instituto SENAI de Sistemas Avançados de Saúde (CIMATEC ISI-SAS). Centro Universitário SENAI/CIMATEC. Salvador, BA, Brasil.Department of Laboratory Medicine. Karolinska Institute. Stockholm, Sweden.University of Modena and Reggio Emilia. Division of Oncology. Laboratory of Cellular Therapy. Modena, Italy.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Neurobiologia Celular e Molecular. Rio de Janeiro, RJ, Brasil / Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Neurobiologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Neurological disorders include a wide spectrum of clinical conditions affecting the central and peripheral nervous systems. For these conditions, which affect hundreds of millions of people worldwide, generally limited or no treatments are available, and cell-based therapies have been intensively investigated in preclinical and clinical studies. Among the available cell types, mesenchymal stem/stromal cells (MSCs) have been widely studied but as yet no cell-based treatment exists for neurological disease. We review current knowledge of the therapeutic potential of MSC-based therapies for neurological diseases, as well as possible mechanisms of action that may be explored to hasten the development of new and effective treatments. We also discuss the challenges for culture conditions, quality control, and the development of potency tests, aiming to generate more efficient cell therapy products for neurological disorders.engFrontiers MediaMesenchymal Stem CellsExtracellular VesiclesRegenerative MedicineCell- and Tissue-Based TherapyNeuroprotectionCélulas-tronco mesenquimaisVesículas extracelularesMedicina regenerativaTerapia celularDoenças neurológicasNeuroproteçãoMesenchymal stem cellsExtracellular vesiclesRegenerative medicineCell therapyNeurological diseasesNeuroprotectionCélulas-Tronco MesenquimaisVesículas ExtracelularesMedicina RegenerativaDoenças do Sistema NervosoNeuroproteçãoCurrent status of mesenchymal stem/stromal cells for treatment of neurological diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55140/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSoares, Milena B. P. - Current Status of Mesenchymal.pdfSoares, Milena B. P. - Current Status of Mesenchymal.pdfapplication/pdf1161477https://www.arca.fiocruz.br/bitstream/icict/55140/2/Soares%2c%20Milena%20B.%20P.%20%20-%20Current%20Status%20of%20Mesenchymal.pdfbed86aacd4574c998e30a43789d35a9dMD52icict/551402023-03-15 14:32:50.927oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:50Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
title Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
spellingShingle Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
Soares, Milena B. P
Mesenchymal Stem Cells
Extracellular Vesicles
Regenerative Medicine
Cell- and Tissue-Based Therapy
Neuroprotection
Células-tronco mesenquimais
Vesículas extracelulares
Medicina regenerativa
Terapia celular
Doenças neurológicas
Neuroproteção
Mesenchymal stem cells
Extracellular vesicles
Regenerative medicine
Cell therapy
Neurological diseases
Neuroprotection
Células-Tronco Mesenquimais
Vesículas Extracelulares
Medicina Regenerativa
Doenças do Sistema Nervoso
Neuroproteção
title_short Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
title_full Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
title_fullStr Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
title_full_unstemmed Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
title_sort Current status of mesenchymal stem/stromal cells for treatment of neurological diseases
author Soares, Milena B. P
author_facet Soares, Milena B. P
Gonçalves, Renata G. J
Vasques, Juliana F
Silva Junior, Almir J. da
Gubert, Fernanda
Santos, Girlaine Café
Santana, Thaís Alves de
Sampaio, Gabriela Louise Almeida
Silva, Daniela Nascimento
Dominici, Massimo
Otero, Rosalia Mendez
author_role author
author2 Gonçalves, Renata G. J
Vasques, Juliana F
Silva Junior, Almir J. da
Gubert, Fernanda
Santos, Girlaine Café
Santana, Thaís Alves de
Sampaio, Gabriela Louise Almeida
Silva, Daniela Nascimento
Dominici, Massimo
Otero, Rosalia Mendez
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Milena B. P
Gonçalves, Renata G. J
Vasques, Juliana F
Silva Junior, Almir J. da
Gubert, Fernanda
Santos, Girlaine Café
Santana, Thaís Alves de
Sampaio, Gabriela Louise Almeida
Silva, Daniela Nascimento
Dominici, Massimo
Otero, Rosalia Mendez
dc.subject.mesh.en_US.fl_str_mv Mesenchymal Stem Cells
Extracellular Vesicles
Regenerative Medicine
Cell- and Tissue-Based Therapy
Neuroprotection
topic Mesenchymal Stem Cells
Extracellular Vesicles
Regenerative Medicine
Cell- and Tissue-Based Therapy
Neuroprotection
Células-tronco mesenquimais
Vesículas extracelulares
Medicina regenerativa
Terapia celular
Doenças neurológicas
Neuroproteção
Mesenchymal stem cells
Extracellular vesicles
Regenerative medicine
Cell therapy
Neurological diseases
Neuroprotection
Células-Tronco Mesenquimais
Vesículas Extracelulares
Medicina Regenerativa
Doenças do Sistema Nervoso
Neuroproteção
dc.subject.other.en_US.fl_str_mv Células-tronco mesenquimais
Vesículas extracelulares
Medicina regenerativa
Terapia celular
Doenças neurológicas
Neuroproteção
dc.subject.en.en_US.fl_str_mv Mesenchymal stem cells
Extracellular vesicles
Regenerative medicine
Cell therapy
Neurological diseases
Neuroprotection
dc.subject.decs.en_US.fl_str_mv Células-Tronco Mesenquimais
Vesículas Extracelulares
Medicina Regenerativa
Doenças do Sistema Nervoso
Neuroproteção
description Departamento de Ciência e Tecnologia (DECIT/MS) do Ministério da Saúde. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-14T14:31:24Z
dc.date.available.fl_str_mv 2022-10-14T14:31:24Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, Milena B. P. et al. Current status of mesenchymal stem/stromal cells for treatment of neurological diseases. Frontiers in Molecular Neuroscience, v. 15, p. 1-36, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55140
dc.identifier.issn.en_US.fl_str_mv 1662-5099
dc.identifier.doi.none.fl_str_mv 10.3389/fnmol.2022.883378
identifier_str_mv SOARES, Milena B. P. et al. Current status of mesenchymal stem/stromal cells for treatment of neurological diseases. Frontiers in Molecular Neuroscience, v. 15, p. 1-36, 2022.
1662-5099
10.3389/fnmol.2022.883378
url https://www.arca.fiocruz.br/handle/icict/55140
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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