Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus

Detalhes bibliográficos
Autor(a) principal: Santos, Ana Paula dos
Data de Publicação: 2005
Outros Autores: Bertho, Alvaro Luiz, Dias, Daniela Capuzzo, Santos, Jaciara Ramos, Marcovistz, Rugimar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37446
Resumo: Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil.
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spelling Santos, Ana Paula dosBertho, Alvaro LuizDias, Daniela CapuzzoSantos, Jaciara RamosMarcovistz, Rugimar2019-11-28T13:34:33Z2019-11-28T13:34:33Z2005SANTOS, Ana Paula dos et al. Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 3, p. 331-337, May 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/3744610.1590/s0074-027620050003000211678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Febre AmarelaVacinaCitometria de fluxoAnticorpos neutralizantesSubconjuntos de linfócitosYellow feverVaccineFlow cytometryNeutralizing antibodiesLymphocyte subsetsLymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil.In this study the kinetics of humoral and cellular immune responses in first-time vaccinees and re-vaccinees with the yellow fever 17DD vaccine virus was analyzed. Flow cytometric analyses were used to determine percentual values of T and B cells in parallel to the yellow fever neutralizing antibody production. All lymphocyte subsets analyzed were augmented around the 30th post vaccination day, both for first-time vaccinees and re-vaccinees. CD3+ T cells increased from 30.8% (SE +/- 4%) to 61.15% (SE +/- 4.2%), CD4+ T cells from 22.4% (SE +/- 3.6%) to 39.17% (SE +/- 2%) with 43% of these cells corresponding to CD4+CD45RO+ T cells, CD8+ T cells from 15.2% (SE +/- 2.9%) to 27% (SE +/- 3%) with 70% corresponding to CD8+CD45RO+ T cells in first-time vaccinees. In re-vaccinees, the CD3+ T cells increased from 50.7% (SE +/- 3%) to 80% (SE +/- 2.3%), CD4+ T cells from 24.9% (SE +/- 1.4%) to 40% (SE +/- 3%) presenting a percentage of 95% CD4+CD45RO+ T cells, CD8+ T cells from 19.7% (SE +/- 1.8%) to 25% (SE +/- 2%). Among CD8+CD38+ T cells there could be observed an increase from 15 to 41.6% in first-time vaccinees and 20.7 to 62.6% in re-vaccinees. Regarding neutralizing antibodies, the re-vaccinees presented high titers even before re-vaccination. The levels of neutralizing antibodies of first-time vaccinees were similar to those presented by re-vaccinees at day 30 after vaccination, indicating the success of primary vaccination. Our data provide a basis for further studies on immunological behavior of the YF 17DD vaccine.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37446/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJaciaraRamos_AlvaroBertho_etal_IOC_2005.pdfJaciaraRamos_AlvaroBertho_etal_IOC_2005.pdfapplication/pdf249028https://www.arca.fiocruz.br/bitstream/icict/37446/2/JaciaraRamos_AlvaroBertho_etal_IOC_2005.pdf1b8458b7ca216f02f62f536bcc52ba4fMD52TEXTJaciaraRamos_AlvaroBertho_etal_IOC_2005.pdf.txtJaciaraRamos_AlvaroBertho_etal_IOC_2005.pdf.txtExtracted texttext/plain27220https://www.arca.fiocruz.br/bitstream/icict/37446/3/JaciaraRamos_AlvaroBertho_etal_IOC_2005.pdf.txt2fda852eb6b809b28b3e014caa4b3e4aMD53icict/374462019-12-02 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dc.title.pt_BR.fl_str_mv Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
title Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
spellingShingle Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
Santos, Ana Paula dos
Febre Amarela
Vacina
Citometria de fluxo
Anticorpos neutralizantes
Subconjuntos de linfócitos
Yellow fever
Vaccine
Flow cytometry
Neutralizing antibodies
Lymphocyte subsets
title_short Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
title_full Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
title_fullStr Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
title_full_unstemmed Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
title_sort Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus
author Santos, Ana Paula dos
author_facet Santos, Ana Paula dos
Bertho, Alvaro Luiz
Dias, Daniela Capuzzo
Santos, Jaciara Ramos
Marcovistz, Rugimar
author_role author
author2 Bertho, Alvaro Luiz
Dias, Daniela Capuzzo
Santos, Jaciara Ramos
Marcovistz, Rugimar
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos, Ana Paula dos
Bertho, Alvaro Luiz
Dias, Daniela Capuzzo
Santos, Jaciara Ramos
Marcovistz, Rugimar
dc.subject.other.pt_BR.fl_str_mv Febre Amarela
Vacina
Citometria de fluxo
Anticorpos neutralizantes
Subconjuntos de linfócitos
topic Febre Amarela
Vacina
Citometria de fluxo
Anticorpos neutralizantes
Subconjuntos de linfócitos
Yellow fever
Vaccine
Flow cytometry
Neutralizing antibodies
Lymphocyte subsets
dc.subject.en.pt_BR.fl_str_mv Yellow fever
Vaccine
Flow cytometry
Neutralizing antibodies
Lymphocyte subsets
description Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-11-28T13:34:33Z
dc.date.available.fl_str_mv 2019-11-28T13:34:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Ana Paula dos et al. Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 3, p. 331-337, May 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37446
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762005000300021
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SANTOS, Ana Paula dos et al. Lymphocyte subset analyses in healthy adults vaccinated with yellow fever 17DD virus. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 3, p. 331-337, May 2005.
0074-0276
10.1590/s0074-02762005000300021
1678-8060
url https://www.arca.fiocruz.br/handle/icict/37446
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/37446/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/37446/3/JaciaraRamos_AlvaroBertho_etal_IOC_2005.pdf.txt
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