Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults

Detalhes bibliográficos
Autor(a) principal: Noronha, Beatriz Prado
Data de Publicação: 2021
Outros Autores: Mambrini, Juliana Vaz de Melo, Torres, Karen Cecília Lima, Martins Filho, Olindo Assis, Carvalho, Andréa Teixeira de, Costa, Maria Fernanda Furtado Lima, Peixoto, Sérgio William Viana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51530
Resumo: René Rachou Institute. Oswaldo Cruz Foundation. Health Studies Center, Public Health and Aging. Belo Horizonte, MG, Brazil.
id CRUZ_6788c76798801ba3ce195bd34dc16a77
oai_identifier_str oai:www.arca.fiocruz.br:icict/51530
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Noronha, Beatriz PradoMambrini, Juliana Vaz de MeloTorres, Karen Cecília LimaMartins Filho, Olindo AssisCarvalho, Andréa Teixeira deCosta, Maria Fernanda Furtado LimaPeixoto, Sérgio William Viana2022-03-03T18:54:34Z2022-03-03T18:54:34Z2021NORONHA Beatriz Prado, et al. Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults. Exp Gerontol., v. 149, 111337, 2021. doi: 10.1016/j.exger.2021.111337.0531-5565https://www.arca.fiocruz.br/handle/icict/5153010.1016/j.exger.2021.111337engElsevier ScienceCytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adultsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRené Rachou Institute. Oswaldo Cruz Foundation. Health Studies Center, Public Health and Aging. Belo Horizonte, MG, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Health Studies Center, Public Health and Aging. Belo Horizonte, MG, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Integrated Research Group on Biomarkers. Belo Horizonte, MG, Brazil/José do Rosário Vellano University. Belo Horizonte, MG, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Integrated Research Group on Biomarkers. Belo Horizonte, MG, BrazilRené Rachou Institute. Oswaldo Cruz Foundation. Integrated Research Group on Biomarkers. Belo Horizonte, MG, BrazilRené Rachou Institute. Oswaldo Cruz Foundation. Health Studies Center, Public Health and Aging. Belo Horizonte, MG, Brazil.René Rachou Institute. Oswaldo Cruz Foundation. Health Studies Center, Public Health and Aging. Belo Horizonte, MG, Brazil/ Federal University of Minas Gerais, Nursing School, Department of Health Management. Belo Horizonte, MG, Brazil.Chronic infections, such as cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1), contribute to the inflammation process among older adults and are associated with the immunosenescence process. The aim was to identify the immunological profile associated with CMV and HSV-1 infections among older adults. This is a cross-sectional study, carried out with 1492 participants from the Bambuí Cohort Study of Aging - Minas Gerais, Brazil. For analysis purposes, we considered the presence of immunoglobulin G (IgG) for CMV and HSV-1 in the participants' serum, assessed by the enzyme-linked immunosorbent assay (ELISA); outcomes were defined by titration above the median (>160 UR/mL for HSV-1 and >399.5 U/mL for CMV). In order to assess the immunological profile, the following biomarkers were considered: IL-1beta, IL-10, IL-12, TNF, CXCL8, CXCL9, CXCL10, CCL2, CCL5, IL-6 and CRP; the first four being categorized as detectable levels or not, and the others using the Classification and Regression Tree (CART) method. The analysis was adjusted for sociodemographic variables, health behaviors and health conditions. The seroprevalence of anti CMV and anti HSV-1 antibodies was 99.4% and 97.0%, respectively. Higher concentrations of CXCL8 and CCL5 chemokines were associated with lower antibody titers for CMV, and higher concentrations of CXCL9, IL-6 and CRP were associated with higher levels of antibodies to CMV. Moreover, intermediate levels of CXCL10 were also associated with higher levels of antibodies to CMV. In HSV-1 infection, intermediate levels of CXCL9, CCL5 and IL-6 were less likely to have higher antibody titers for this infection. On the other hand, higher levels of CXCL10 and CRP were positively associated with higher antibody titers for HSV-1. The results describe important immunological changes and reinforce the potential effect of CMV and HSV-1 on the immunosenescence process.CytomegalovirusHerpes simplex virus type 1Immunological profileInflammationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51530/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCytomegalovirus and herpes simplex type...lder adults _ Elsevier Enhanced Reader.pdfCytomegalovirus and herpes simplex type...lder adults _ Elsevier Enhanced Reader.pdfapplication/pdf4623344https://www.arca.fiocruz.br/bitstream/icict/51530/2/Cytomegalovirus%20and%20herpes%20simplex%20type...lder%20adults%20_%20Elsevier%20Enhanced%20Reader.pdf1a2df0cdc155b79b67007b1963903eb5MD52icict/515302022-03-03 15:54:34.644oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-03-03T18:54:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
title Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
spellingShingle Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
Noronha, Beatriz Prado
Cytomegalovirus
Herpes simplex virus type 1
Immunological profile
Inflammation
title_short Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
title_full Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
title_fullStr Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
title_full_unstemmed Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
title_sort Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
author Noronha, Beatriz Prado
author_facet Noronha, Beatriz Prado
Mambrini, Juliana Vaz de Melo
Torres, Karen Cecília Lima
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Costa, Maria Fernanda Furtado Lima
Peixoto, Sérgio William Viana
author_role author
author2 Mambrini, Juliana Vaz de Melo
Torres, Karen Cecília Lima
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Costa, Maria Fernanda Furtado Lima
Peixoto, Sérgio William Viana
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Noronha, Beatriz Prado
Mambrini, Juliana Vaz de Melo
Torres, Karen Cecília Lima
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Costa, Maria Fernanda Furtado Lima
Peixoto, Sérgio William Viana
dc.subject.en.pt_BR.fl_str_mv Cytomegalovirus
Herpes simplex virus type 1
Immunological profile
Inflammation
topic Cytomegalovirus
Herpes simplex virus type 1
Immunological profile
Inflammation
description René Rachou Institute. Oswaldo Cruz Foundation. Health Studies Center, Public Health and Aging. Belo Horizonte, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-03-03T18:54:34Z
dc.date.available.fl_str_mv 2022-03-03T18:54:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NORONHA Beatriz Prado, et al. Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults. Exp Gerontol., v. 149, 111337, 2021. doi: 10.1016/j.exger.2021.111337.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51530
dc.identifier.issn.pt_BR.fl_str_mv 0531-5565
dc.identifier.doi.none.fl_str_mv 10.1016/j.exger.2021.111337
identifier_str_mv NORONHA Beatriz Prado, et al. Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults. Exp Gerontol., v. 149, 111337, 2021. doi: 10.1016/j.exger.2021.111337.
0531-5565
10.1016/j.exger.2021.111337
url https://www.arca.fiocruz.br/handle/icict/51530
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51530/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51530/2/Cytomegalovirus%20and%20herpes%20simplex%20type...lder%20adults%20_%20Elsevier%20Enhanced%20Reader.pdf
bitstream.checksum.fl_str_mv 9193a7c197bc67acd023525e72a03240
1a2df0cdc155b79b67007b1963903eb5
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324688681697280

Registros relacionados