Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory

Detalhes bibliográficos
Autor(a) principal: Santos, José Augusto Albuquerque
Data de Publicação: 2021
Outros Autores: Gomes, Keyla Nunes Farias, Lima, Lucas Vinicius, Faria, Robson Xavier
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50262
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil.
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spelling Santos, José Augusto AlbuquerqueGomes, Keyla Nunes FariasLima, Lucas ViniciusFaria, Robson Xavier2021-12-09T20:05:53Z2021-12-09T20:05:53Z2021SANTOS, José Augusto Albuquerque et al. Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory. Open Access Journal of Biomedical Science, v. 4, n. 6, p. 1208-1214, 2021.2690-487Xhttps://www.arca.fiocruz.br/handle/icict/5026210.38125/OAJBS.000333engBMCPlectranthus grandisEsquistossomíaseProdutos naturaisSchistosomíasisPlectranthus grandisNatural productsBioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratoryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Mestrado em Ciências Biológicas e Biotecnologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Escola Politécnica de Saúde Joaquim Venâncio. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil.The objective of this work was to test the bioactivity of the different extracts and fractions of the leaves of Plectranthus grandis and to determine their lethal concentrations on Biomphalaria glabrata. For the bioassays, seven crude extracts obtained in soxhlet extractor with organic solvents and five fractions were used by flash filtration chromatography. The bioassays were performed in 200mL glass and 24-well plates, using 1674 mollusks in the bioassays. The results showed that the 500mg/L beaker tests obtained 100% mortality rate for the crude extracts in hexane and dichloromethane and 93% for chloroform extract. In plaque tests, the dichloromethane extracts the lowest CL90 = 318mg/L. The mortality rate with the fractions was 100% at a concentration of 300mg/L. It was concluded that the tests performed on cups and plates showed significant results.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50262/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseAugustoSantos_etal_IOC_2021.pdfJoseAugustoSantos_etal_IOC_2021.pdfapplication/pdf879149https://www.arca.fiocruz.br/bitstream/icict/50262/2/JoseAugustoSantos_etal_IOC_2021.pdfa8c130186b8f70c23b90729752314924MD52icict/502622021-12-09 17:05:53.585oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-12-09T20:05:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory
title Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory
spellingShingle Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory
Santos, José Augusto Albuquerque
Plectranthus grandis
Esquistossomíase
Produtos naturais
Schistosomíasis
Plectranthus grandis
Natural products
title_short Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory
title_full Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory
title_fullStr Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory
title_full_unstemmed Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory
title_sort Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory
author Santos, José Augusto Albuquerque
author_facet Santos, José Augusto Albuquerque
Gomes, Keyla Nunes Farias
Lima, Lucas Vinicius
Faria, Robson Xavier
author_role author
author2 Gomes, Keyla Nunes Farias
Lima, Lucas Vinicius
Faria, Robson Xavier
author2_role author
author
author
dc.contributor.author.fl_str_mv Santos, José Augusto Albuquerque
Gomes, Keyla Nunes Farias
Lima, Lucas Vinicius
Faria, Robson Xavier
dc.subject.other.pt_BR.fl_str_mv Plectranthus grandis
Esquistossomíase
Produtos naturais
topic Plectranthus grandis
Esquistossomíase
Produtos naturais
Schistosomíasis
Plectranthus grandis
Natural products
dc.subject.en.pt_BR.fl_str_mv Schistosomíasis
Plectranthus grandis
Natural products
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-09T20:05:53Z
dc.date.available.fl_str_mv 2021-12-09T20:05:53Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, José Augusto Albuquerque et al. Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory. Open Access Journal of Biomedical Science, v. 4, n. 6, p. 1208-1214, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50262
dc.identifier.issn.pt_BR.fl_str_mv 2690-487X
dc.identifier.doi.none.fl_str_mv 10.38125/OAJBS.000333
identifier_str_mv SANTOS, José Augusto Albuquerque et al. Bioactivity of Plectranthus grandis (L.H. Cramer) R.H. Willemse Extracts on Biomphalaria glabrata (Say, 1818) in Laboratory. Open Access Journal of Biomedical Science, v. 4, n. 6, p. 1208-1214, 2021.
2690-487X
10.38125/OAJBS.000333
url https://www.arca.fiocruz.br/handle/icict/50262
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50262/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50262/2/JoseAugustoSantos_etal_IOC_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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