Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters

Detalhes bibliográficos
Autor(a) principal: Tanaka, Tayana Serpa Ortiz
Data de Publicação: 2022
Outros Autores: Cesar, Gabriela Alves, Rezende, Grazielli Rocha de, Puga, Marco Antonio Moreira, Weis-Torres, Sabrina Moreira dos Santos, Bandeira, Larissa Melo, Pompílio, Maurício Antônio, Croda, Julio, Guimarães, Monick Lindenmeyer Guimarães, Castro, Ana Rita Coimbra Motta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55118
Resumo: Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.
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spelling Tanaka, Tayana Serpa OrtizCesar, Gabriela AlvesRezende, Grazielli Rocha dePuga, Marco Antonio MoreiraWeis-Torres, Sabrina Moreira dos SantosBandeira, Larissa MeloPompílio, Maurício AntônioCroda, JulioGuimarães, Monick Lindenmeyer GuimarãesCastro, Ana Rita Coimbra Motta2022-10-12T12:13:59Z2022-10-12T12:13:59Z2022TANAKA, Tayana Serpa Ortiz et al. Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters. Viruses, v. 14, 1660, p. 1 - 15, July 2022.1999-4915https://www.arca.fiocruz.br/handle/icict/5511810.3390/v14081660engMDPIHIVPopulação vulnerávelEpidemiologia molecularMutações de resistência a medicamentosRede de transmissãoHIVVulnerable populationDrug resistance mutationsTransmission networkMolecular epidedmiologyMolecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clustersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil.Higher rates of human immunodeficiency virus (HIV) infection have been detected in prisoners when compared with the general population, but research into HIV molecular epidemiology and its transmission network has been lacking among them. Thus, this study aimed to verify potential HIV molecular transmission networks among prisoners. In addition, we aimed to describe the mutations related to antiretroviral resistance in these isolates. Thus, we conducted a cross-sectional survey from 2013 to 2018 in prisons in Central-Western Brazil, and the final sampling composed of 84 prisoners. Proviral DNA was extracted from each whole blood sample followed by amplification of the partial polymerase gene and sequencing. Forty-nine sequences (58.3%) were classified as subtype B, followed by C (14.3%), D, and F1 (2.4% each). A complex and dynamic HIV-1 epidemic is observed in the prisons, as 25% of the sequences were recombinant forms. We detected 15 HIV transmission clusters composed of at least two sequences, that included not only prisoners but also individuals from the general population from the same State with a variety of risk behaviors. Thirtytwo percent (32.0%) of treatment-experienced prisoners had at least one drug resistance mutation (DRM), while transmitted DRMs were found in 5.9% of the prisoners. We highlight the urgent need for routine surveillance of HIV-1 infection including resistance genotypic tests considering the high disease burden, risky behaviors inside prisons, and the dynamic relationship of prisoners with the outside community.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55118/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMonickGuimaraes_TayanaTanaka_etal_IOC_2022..pdfMonickGuimaraes_TayanaTanaka_etal_IOC_2022..pdfapplication/pdf1411373https://www.arca.fiocruz.br/bitstream/icict/55118/2/MonickGuimaraes_TayanaTanaka_etal_IOC_2022..pdf5bd36196c9855cdfcc7f7622129882b7MD52icict/551182023-09-04 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dc.title.en_US.fl_str_mv Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters
title Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters
spellingShingle Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters
Tanaka, Tayana Serpa Ortiz
HIV
População vulnerável
Epidemiologia molecular
Mutações de resistência a medicamentos
Rede de transmissão
HIV
Vulnerable population
Drug resistance mutations
Transmission network
Molecular epidedmiology
title_short Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters
title_full Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters
title_fullStr Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters
title_full_unstemmed Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters
title_sort Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters
author Tanaka, Tayana Serpa Ortiz
author_facet Tanaka, Tayana Serpa Ortiz
Cesar, Gabriela Alves
Rezende, Grazielli Rocha de
Puga, Marco Antonio Moreira
Weis-Torres, Sabrina Moreira dos Santos
Bandeira, Larissa Melo
Pompílio, Maurício Antônio
Croda, Julio
Guimarães, Monick Lindenmeyer Guimarães
Castro, Ana Rita Coimbra Motta
author_role author
author2 Cesar, Gabriela Alves
Rezende, Grazielli Rocha de
Puga, Marco Antonio Moreira
Weis-Torres, Sabrina Moreira dos Santos
Bandeira, Larissa Melo
Pompílio, Maurício Antônio
Croda, Julio
Guimarães, Monick Lindenmeyer Guimarães
Castro, Ana Rita Coimbra Motta
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tanaka, Tayana Serpa Ortiz
Cesar, Gabriela Alves
Rezende, Grazielli Rocha de
Puga, Marco Antonio Moreira
Weis-Torres, Sabrina Moreira dos Santos
Bandeira, Larissa Melo
Pompílio, Maurício Antônio
Croda, Julio
Guimarães, Monick Lindenmeyer Guimarães
Castro, Ana Rita Coimbra Motta
dc.subject.other.en_US.fl_str_mv HIV
População vulnerável
Epidemiologia molecular
Mutações de resistência a medicamentos
Rede de transmissão
topic HIV
População vulnerável
Epidemiologia molecular
Mutações de resistência a medicamentos
Rede de transmissão
HIV
Vulnerable population
Drug resistance mutations
Transmission network
Molecular epidedmiology
dc.subject.en.en_US.fl_str_mv HIV
Vulnerable population
Drug resistance mutations
Transmission network
Molecular epidedmiology
description Universidade Federal do Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-12T12:13:59Z
dc.date.available.fl_str_mv 2022-10-12T12:13:59Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TANAKA, Tayana Serpa Ortiz et al. Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters. Viruses, v. 14, 1660, p. 1 - 15, July 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55118
dc.identifier.issn.en_US.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v14081660
identifier_str_mv TANAKA, Tayana Serpa Ortiz et al. Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters. Viruses, v. 14, 1660, p. 1 - 15, July 2022.
1999-4915
10.3390/v14081660
url https://www.arca.fiocruz.br/handle/icict/55118
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55118/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55118/2/MonickGuimaraes_TayanaTanaka_etal_IOC_2022..pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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