Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus

Detalhes bibliográficos
Autor(a) principal: Moura, Carlos Geraldo Guerreiro de
Data de Publicação: 2009
Outros Autores: Lima, Isabella, Barbosa, Lúcio Macedo, Athanazio, Daniel Abensur, Reis, Eliana Almeida Gomes, Reis, Mitermayer Galvão dos, Burlingame, Rufus W., Santiago, Mittermayer Barreto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7517
Resumo: Hospital Santo Antônio. Escola Bahiana de Medicina e Saude Publica. Salvador, BA, Brasil.
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spelling Moura, Carlos Geraldo Guerreiro deLima, IsabellaBarbosa, Lúcio MacedoAthanazio, Daniel AbensurReis, Eliana Almeida GomesReis, Mitermayer Galvão dosBurlingame, Rufus W.Santiago, Mittermayer Barreto2014-04-14T17:10:50Z2014-04-14T17:10:50Z2009MOURA, C. G. et al. Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus. Journal of Clinical Laboratory Analisis, v. 23, p. 19-23, 2009.1098-2825https://www.arca.fiocruz.br/handle/icict/751710.1002/jcla.20280engWiley PeriodicalsAnti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Santo Antônio. Escola Bahiana de Medicina e Saude Publica. Salvador, BA, Brasil.Hospital do Santa Izabel. Serviço de Reumatologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.INOVA Diagnostics Inc. San Diego, Califórnia, USA.Escola Bahiana de Medicina e Saúde Publica. Serviço de Reumatologia do Hospital do Santa Izabel. Salvador, BA, Brasil.BACKGROUND: Anti-C1q antibodies have been described in systemic lupus erythematosus (SLE) as well as in other connective tissue diseases. They have been considered as a marker for disease activity and presence of nephritis. OBJECTIVE: The aim of this study was to determine the prevalence of anti-C1q antibodies in Brazilian lupus patients as well as analyze their association with different clinical and serologic parameters. METHODS: Sera from 81 SLE patients, based on the American College of Rheumatology (ACR) criteria, were collected from a lupus referral outpatient clinic in Salvador, Brazil. Antibodies to C1q were detected by an enzyme-linked immunoassay (ELISA) kit and antibodies to other cellular antigens identified by indirect immunofluorescence on HEp-2 cell substrate (ANA), or Crithidia luciliae (dsDNA), and to nucleosome by ELISA. A cutoff of 20 U was established for anti-C1q and anti nucleosome assays. RESULTS: Anti-C1q antibodies were detected in 39.5% (32/81) of SLE sera. The presence of anti-C1q antibodies was associated with proteinuria (P=0.028) but not with other laboratory or clinical features, such as anti nucleosome or anti-dsDNA antibodies, hematuria, urinary casts or renal failure, leukopenia, pericarditis, pleuritis, malar rash, seizures, and psychosis. There was a positive correlation between the titers of anti-C1q antibodies and the systemic lupuis erythematosus disease activity index (SLEDAI) score (r=0.370; P=0.001). CONCLUSION: This study in Brazilian SLE patients confirms previous findings of the association of anti-C1q antibodies with nephritis and disease activity.AutoantibodiesAnti-C1q antibodiesSystemic lupus erythematosusNephritisAutoanticorpos/análiseComplemento C1q/imunologiaLúpus Eritematoso Sistêmico/imunologiaNefrite/imunologiaAdultoBrasilEstudos TransversaisFemininoTécnica Indireta de Fluorescência para AnticorpoHumanosMasculinoMeia-IdadeEstatísticas não Paramétricasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMOURA CG Anti-C1q antibodies....pdfMOURA CG Anti-C1q antibodies....pdfapplication/pdf94099https://www.arca.fiocruz.br/bitstream/icict/7517/1/MOURA%20CG%20Anti-C1q%20antibodies....pdf0897d957ab43e924c753c192c9e53a07MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7517/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMOURA CG Anti-C1q antibodies....pdf.txtMOURA CG Anti-C1q antibodies....pdf.txtExtracted texttext/plain19110https://www.arca.fiocruz.br/bitstream/icict/7517/5/MOURA%20CG%20Anti-C1q%20antibodies....pdf.txt6a1abe771921d34ac91871d134c8e77dMD55THUMBNAILMOURA CG Anti-C1q antibodies....pdf.jpgMOURA CG Anti-C1q antibodies....pdf.jpgGenerated Thumbnailimage/jpeg1992https://www.arca.fiocruz.br/bitstream/icict/7517/4/MOURA%20CG%20Anti-C1q%20antibodies....pdf.jpgb39d0f9c60b3fd0475930c841d3ab0f8MD54icict/75172023-03-15 14:33:03.986oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
title Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
spellingShingle Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
Moura, Carlos Geraldo Guerreiro de
Autoantibodies
Anti-C1q antibodies
Systemic lupus erythematosus
Nephritis
Autoanticorpos/análise
Complemento C1q/imunologia
Lúpus Eritematoso Sistêmico/imunologia
Nefrite/imunologia
Adulto
Brasil
Estudos Transversais
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Humanos
Masculino
Meia-Idade
Estatísticas não Paramétricas
title_short Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
title_full Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
title_fullStr Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
title_full_unstemmed Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
title_sort Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus
author Moura, Carlos Geraldo Guerreiro de
author_facet Moura, Carlos Geraldo Guerreiro de
Lima, Isabella
Barbosa, Lúcio Macedo
Athanazio, Daniel Abensur
Reis, Eliana Almeida Gomes
Reis, Mitermayer Galvão dos
Burlingame, Rufus W.
Santiago, Mittermayer Barreto
author_role author
author2 Lima, Isabella
Barbosa, Lúcio Macedo
Athanazio, Daniel Abensur
Reis, Eliana Almeida Gomes
Reis, Mitermayer Galvão dos
Burlingame, Rufus W.
Santiago, Mittermayer Barreto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura, Carlos Geraldo Guerreiro de
Lima, Isabella
Barbosa, Lúcio Macedo
Athanazio, Daniel Abensur
Reis, Eliana Almeida Gomes
Reis, Mitermayer Galvão dos
Burlingame, Rufus W.
Santiago, Mittermayer Barreto
dc.subject.en.pt_BR.fl_str_mv Autoantibodies
Anti-C1q antibodies
Systemic lupus erythematosus
Nephritis
topic Autoantibodies
Anti-C1q antibodies
Systemic lupus erythematosus
Nephritis
Autoanticorpos/análise
Complemento C1q/imunologia
Lúpus Eritematoso Sistêmico/imunologia
Nefrite/imunologia
Adulto
Brasil
Estudos Transversais
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Humanos
Masculino
Meia-Idade
Estatísticas não Paramétricas
dc.subject.decs.pt_BR.fl_str_mv Autoanticorpos/análise
Complemento C1q/imunologia
Lúpus Eritematoso Sistêmico/imunologia
Nefrite/imunologia
Adulto
Brasil
Estudos Transversais
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Humanos
Masculino
Meia-Idade
Estatísticas não Paramétricas
description Hospital Santo Antônio. Escola Bahiana de Medicina e Saude Publica. Salvador, BA, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2014-04-14T17:10:50Z
dc.date.available.fl_str_mv 2014-04-14T17:10:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MOURA, C. G. et al. Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus. Journal of Clinical Laboratory Analisis, v. 23, p. 19-23, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7517
dc.identifier.issn.none.fl_str_mv 1098-2825
dc.identifier.doi.pt_BR.fl_str_mv 10.1002/jcla.20280
identifier_str_mv MOURA, C. G. et al. Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus. Journal of Clinical Laboratory Analisis, v. 23, p. 19-23, 2009.
1098-2825
10.1002/jcla.20280
url https://www.arca.fiocruz.br/handle/icict/7517
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Wiley Periodicals
publisher.none.fl_str_mv Wiley Periodicals
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
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