Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil

Detalhes bibliográficos
Autor(a) principal: Pereira, Felicidade Mota
Data de Publicação: 2019
Outros Autores: Almeida, Maria da Conceição Chagas de, Santos, Fred Luciano Neves, Carreiro, Roberto Perez, Silva, Carlos Gustavo Regis, Castro Filho, Bernardo Galvão, Grassi, Maria Fernanda Rios
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33128
Resumo: National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq), the National Foundation for the Development of Higher Education (Fundação Nacional para o Desenvolvimento do Ensino Superior-FUNDADESP), and the Foundation for Research Support of the State of Bahia (Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.
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spelling Pereira, Felicidade MotaAlmeida, Maria da Conceição Chagas deSantos, Fred Luciano NevesCarreiro, Roberto PerezSilva, Carlos Gustavo RegisCastro Filho, Bernardo GalvãoGrassi, Maria Fernanda Rios2019-05-17T13:31:24Z2019-05-17T13:31:24Z2019PEREIRA, Felicidade Mota et al. Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil. Frontiers in Microbiology, v. 10, p. 1-12, 2019.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/3312810.3389/fmicb.2019.01002National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq), the National Foundation for the Development of Higher Education (Fundação Nacional para o Desenvolvimento do Ensino Superior-FUNDADESP), and the Foundation for Research Support of the State of Bahia (Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Secretaria da Saúde do Estado da Bahia. Laboratório Central de Saúde Pública Prof. Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Epidemiologia Molecular e Bioestatística. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública, Salvador, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública, Salvador, Brasil.Background: Salvador, Bahia (northeastern Brazil), has been identified as the epicenter of Human T-cell leukemia virus Human T-cell leukemia virus (HTLV) type 1 infection in the country. This study aims to estimate the rate of HTLV infection and the geographical distribution of this virus in this state. Methods: All HTLV tests (chemiluminescence/ELISA assays/Western Blotting) performed in the Central Laboratory of Public Health of Bahia (LACEN) from 2004 to 2013 were included. Data was extracted from LACEN’s database using high volume extract, transformation and load throughput. Infection rate was expressed as the number of infected individuals per 100,000 inhabitants considering municipalities grouped in microregions and/or mesoregions as the unit of analysis. Results: A total of 233,876 individuals were evaluated. Individuals were from 394 out of 417 municipalities of Bahia (94.5%). HTLV chemiluminescence/ELISA assay was found to be reactive for 3,138 individuals from whom 2,323 had WB results (1,978 positives, 62 negative and 282 indeterminate). Out of 1978 reactive samples, 1,813 (91.7%) were positive for HTLV-1, 58 (2.9%) for HTLV-2 and 107 (5.4%) were for both HTLV-1 and HTLV-2. The cumulative mean rate of HTLV-positive cases in Bahia was 14.4 per 100,000 inhabitants. Three microregions presented rates >20 HTLVpositive cases/100,000 inhabitants: Barreiras (24.83 cases per 100,000 inhabitants), Salvador (22.90 cases per 100,000 inhabitants), and Ilhéus-Itabuna (22.60 cases per 100,000 inhabitants). Conclusion: HTLV infection is disseminated in the state of Bahia, with an overall moderate rate of infection. Further studies should be conducted to characterize the epidemiological and clinical profile of HTLV-infected individuals better and to propose effective prevention measures.engFrontiers MediaHTLVClustersEpidemiologiaBahiaDistribuição espacialHTLVClustersEpidemiologyBahiaSpatial distributionEvidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33128/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPereira FM Front Microbiol 2019.pdfPereira FM Front Microbiol 2019.pdfapplication/pdf7007856https://www.arca.fiocruz.br/bitstream/icict/33128/2/Pereira%20FM%20Front%20Microbiol%202019.pdfa686c7d8db23c266ba2dccc0a311bc2bMD52TEXTPereira 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dc.title.pt_BR.fl_str_mv Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
title Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
spellingShingle Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
Pereira, Felicidade Mota
HTLV
Clusters
Epidemiologia
Bahia
Distribuição espacial
HTLV
Clusters
Epidemiology
Bahia
Spatial distribution
title_short Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
title_full Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
title_fullStr Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
title_full_unstemmed Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
title_sort Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil
author Pereira, Felicidade Mota
author_facet Pereira, Felicidade Mota
Almeida, Maria da Conceição Chagas de
Santos, Fred Luciano Neves
Carreiro, Roberto Perez
Silva, Carlos Gustavo Regis
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
author_role author
author2 Almeida, Maria da Conceição Chagas de
Santos, Fred Luciano Neves
Carreiro, Roberto Perez
Silva, Carlos Gustavo Regis
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Felicidade Mota
Almeida, Maria da Conceição Chagas de
Santos, Fred Luciano Neves
Carreiro, Roberto Perez
Silva, Carlos Gustavo Regis
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
dc.subject.other.pt_BR.fl_str_mv HTLV
Clusters
Epidemiologia
Bahia
Distribuição espacial
topic HTLV
Clusters
Epidemiologia
Bahia
Distribuição espacial
HTLV
Clusters
Epidemiology
Bahia
Spatial distribution
dc.subject.en.pt_BR.fl_str_mv HTLV
Clusters
Epidemiology
Bahia
Spatial distribution
description National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq), the National Foundation for the Development of Higher Education (Fundação Nacional para o Desenvolvimento do Ensino Superior-FUNDADESP), and the Foundation for Research Support of the State of Bahia (Fundação de Amparo à Pesquisa do Estado da Bahia-FAPESB). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-05-17T13:31:24Z
dc.date.available.fl_str_mv 2019-05-17T13:31:24Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEREIRA, Felicidade Mota et al. Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil. Frontiers in Microbiology, v. 10, p. 1-12, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33128
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.pt_BR.fl_str_mv 10.3389/fmicb.2019.01002
identifier_str_mv PEREIRA, Felicidade Mota et al. Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil. Frontiers in Microbiology, v. 10, p. 1-12, 2019.
1664-302X
10.3389/fmicb.2019.01002
url https://www.arca.fiocruz.br/handle/icict/33128
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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