Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy

Detalhes bibliográficos
Autor(a) principal: Pirmez, Claude
Data de Publicação: 1990
Outros Autores: Oliveira Neto, Manoel Paes, Grimaldi Jr., Gabriel, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33564
Resumo: Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Pirmez, ClaudeOliveira Neto, Manoel PaesGrimaldi Jr., GabrielSavino, Wilson2019-06-18T17:42:42Z2019-06-18T17:42:42Z1990PIRMEZ, Claude et al. Immunopathology of american cutaneous leishmaniasis. Modulation of MHC class II gene products by Keratinocytes before and after glucantime therapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 2, p. 203-209, Apr./June 1990.0074-0276https://www.arca.fiocruz.br/handle/icict/3356410.1590/S0074-027619900002000111678-8060engFiocruz/IOCLeishmanioseQueratinócitosTerapia GlucamtimeLeishmaniasisKeratinocytesHLA-DRGlucamtime therapyImmunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Epidermal changes from 32 cutaneous and 3 mucosal American leishmaniasis (ACL) active lesions were studied for HLA-DR, -DP expression, Lanerhans cells and lymphocyte infiltration. In addition to a DR and DQ positivity at the surface of the cells of the inflammatory infiltrate, a strong reaction for DR antigens was detected on keratinocytes. Hyperplasia of Langerhans cells was present in al cutaneous lesions and epidermis was infiltrated by T lymphocytes. When healed lesions of 14 of these subjects were re-biopsied 1 to 12 months after the end of pentavalent antimonial therapy, MHC class antigens could no longer be seen on keratinocytes. Our data represrn evidence for hhe reversibility of the abnormal HLA-DR expression by keratinocytes in ACL after Glucantime therapy or spontaneous scar formation, demonstrating that this expresion is restricted to the period of active lesions. The present findings can be regarded as an indirect evidence that keratinocytes may be involved in the immunopathology of ACL.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33564/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdfWilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdfapplication/pdf1864157https://www.arca.fiocruz.br/bitstream/icict/33564/2/WilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdf86b0e8c79e3ba61ee022b8a6a368f54cMD52TEXTWilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdf.txtWilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdf.txtExtracted texttext/plain7https://www.arca.fiocruz.br/bitstream/icict/33564/3/WilsonSavino_GabrielGrimaldi_etal_IOC_1990.pdf.txt212b0306580d4f0044d18f9a3edcc832MD53icict/335642023-10-25 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dc.title.pt_BR.fl_str_mv Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
title Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
spellingShingle Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
Pirmez, Claude
Leishmaniose
Queratinócitos
Terapia Glucamtime
Leishmaniasis
Keratinocytes
HLA-DR
Glucamtime therapy
title_short Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
title_full Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
title_fullStr Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
title_full_unstemmed Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
title_sort Immunopathology of American Cutaneous Leishmaniasis, modulation of MHC Class II gene products by keratinocytes before and after glucantine therapy
author Pirmez, Claude
author_facet Pirmez, Claude
Oliveira Neto, Manoel Paes
Grimaldi Jr., Gabriel
Savino, Wilson
author_role author
author2 Oliveira Neto, Manoel Paes
Grimaldi Jr., Gabriel
Savino, Wilson
author2_role author
author
author
dc.contributor.author.fl_str_mv Pirmez, Claude
Oliveira Neto, Manoel Paes
Grimaldi Jr., Gabriel
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Queratinócitos
Terapia Glucamtime
topic Leishmaniose
Queratinócitos
Terapia Glucamtime
Leishmaniasis
Keratinocytes
HLA-DR
Glucamtime therapy
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Keratinocytes
HLA-DR
Glucamtime therapy
description Fundação Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 1990
dc.date.issued.fl_str_mv 1990
dc.date.accessioned.fl_str_mv 2019-06-18T17:42:42Z
dc.date.available.fl_str_mv 2019-06-18T17:42:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PIRMEZ, Claude et al. Immunopathology of american cutaneous leishmaniasis. Modulation of MHC class II gene products by Keratinocytes before and after glucantime therapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 2, p. 203-209, Apr./June 1990.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33564
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761990000200011
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv PIRMEZ, Claude et al. Immunopathology of american cutaneous leishmaniasis. Modulation of MHC class II gene products by Keratinocytes before and after glucantime therapy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 2, p. 203-209, Apr./June 1990.
0074-0276
10.1590/S0074-02761990000200011
1678-8060
url https://www.arca.fiocruz.br/handle/icict/33564
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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