Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.

Detalhes bibliográficos
Autor(a) principal: Santiago, Mittermayer Barreto
Data de Publicação: 2004
Outros Autores: Martinelli, Reinaldo, Reis, Mitermayer Galvão dos, Reis, Eliana Almeida Gomes, Ko, Albert Icksang, Fontes, Roberto Dias, Silva, Moacir Paranhos, Nascimento, Eliane Góes, Jesus, Rogério de, Pierangeli, Silvia, Espinola, Ricardo, Gharavi, Azzudin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7558
Resumo: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Núcleo de Reumatologia do Serviço de Clínica Médica. Salvador, BA, Brasil
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spelling Santiago, Mittermayer BarretoMartinelli, ReinaldoReis, Mitermayer Galvão dosReis, Eliana Almeida GomesKo, Albert IcksangFontes, Roberto DiasSilva, Moacir ParanhosNascimento, Eliane GóesJesus, Rogério dePierangeli, SilviaEspinola, RicardoGharavi, Azzudin2014-04-30T14:02:18Z2014-04-30T14:02:18Z2004SANTIAGO, M. B. et al. Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome. Clinical Rheumatology, v. 23, n. 6, p. 485-489, 2004.0770-3198https://www.arca.fiocruz.br/handle/icict/755810.1007/s10067-004-0924-5engClinical RheumatologyDiagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Núcleo de Reumatologia do Serviço de Clínica Médica. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilWeill Medical College. New York, NY, USACOAS/DST/SESAB. Salvador, BA, BrasilPIEJ/SESAB. Jequié, BrasilPIEJ/SESAB. Jequié, BrasilMorehouse School of Medicine. Atlanta, GA, USAMorehouse School of Medicine. Atlanta, GA, USAMorehouse School of Medicine. Atlanta, GA, USAThe objective of the present study was to analyse the performance of the tests for detection of anti-beta2 glycoprotein I (beta2 GP I) and anticardiolipin (aCL) antibodies for identification of clinical manifestations of the antiphospholipid syndrome (APS). Patients with systemic lupus erythematosus (SLE) as well as carriers of infectious diseases such as Kala-azar, syphilis and leptospirosis were studied. Particular interest was given to the presence of clinical complications related to APS. Anticardiolipin and anti-beta2 GP I antibodies were searched using an enzyme-linked immunosorbent assay (ELISA) assay. Clinical manifestations of APS were observed in 34 of the 152 patients (22.3%) with SLE and no patient with infectious disease had such manifestations. Antibodies to cardiolipin in moderate or high levels and anti-beta2 GP I were detected in 55 of 152 (36.1%) and 36 of 152 (23.6%) patients with SLE, respectively, and in 2 of 30 (6.6%) and 16 of 30 (53.3%) patients with Kala-azar, in 9 of 39 (23%) and 6 of 34 (17.6%) patients with leptospirosis, and 14 of 74 (18.9%) and 8 of 70 (11.4%) cases of syphilis, respectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and likelihood ratio (LR) of the anti-beta2 GP I test for the identification of the clinical manifestation of APS were, respectively, 29% [95% confidence interval (CI) = 24%-34%], 78% (95% CI = 73-83%), 15% (95% CI = 11-19%), 89% (95% CI = 85-93%) and 1.38. Regarding the aCL assay, the figure was 29% (95% CI = 24-34%), 76% (95% CI = 71-81%), 14% (95% CI = 10-18%), 89% (95% CI = 86-92%) and 1.26. As the validity and performance of the anti-beta2 GP I assay were similar to the aCL in demonstrating the presence of clinical phenomena associated with APS and due to the difficulties in performing as well as the lack of standardisation of the anti-beta2 GP I test, we suggest that the test for aCL should continue to be the first one performed when the presence of APS is suspectedAnticardiolipinAntiphospholipidDiagnostic testSystemic lupus erythematosusAnticorpos Anticardiolipina/imunologiaSíndrome Antifosfolipídica/sangueAnticorpos Anticardiolipina/sangueSíndrome Antifosfolipídica/diagnósticoGlicoproteínas/sangueAdultoSíndrome Antifosfolipídica/imunologiaEnsaio de Imunoadsorção EnzimáticaFemininoGlicoproteínas/imunologiaHumanosInfecção/sangueInfecção/diagnósticoLúpus Eritematoso Sistêmico/sangueLúpus Eritematoso Sistêmico/diagnósticoMasculinoMeia-Idadebeta 2-Glicoproteína Iinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSantiago MB Diagnostic performance....pdfSantiago MB Diagnostic performance....pdfapplication/pdf190420https://www.arca.fiocruz.br/bitstream/icict/7558/1/Santiago%20MB%20Diagnostic%20performance....pdf118a2e793499119adffba627c0dc74e2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7558/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSantiago MB Diagnostic performance....pdf.txtSantiago MB Diagnostic performance....pdf.txtExtracted texttext/plain21649https://www.arca.fiocruz.br/bitstream/icict/7558/5/Santiago%20MB%20Diagnostic%20performance....pdf.txtb04493aa94336d2f4e95b9e1bfc65b30MD55THUMBNAILSantiago MB Diagnostic performance....pdf.jpgSantiago MB Diagnostic performance....pdf.jpgGenerated Thumbnailimage/jpeg2328https://www.arca.fiocruz.br/bitstream/icict/7558/4/Santiago%20MB%20Diagnostic%20performance....pdf.jpge84386a87af7751802e9c0cdbc188a75MD54icict/75582023-03-15 14:33:17.88oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
title Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
spellingShingle Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
Santiago, Mittermayer Barreto
Anticardiolipin
Antiphospholipid
Diagnostic test
Systemic lupus erythematosus
Anticorpos Anticardiolipina/imunologia
Síndrome Antifosfolipídica/sangue
Anticorpos Anticardiolipina/sangue
Síndrome Antifosfolipídica/diagnóstico
Glicoproteínas/sangue
Adulto
Síndrome Antifosfolipídica/imunologia
Ensaio de Imunoadsorção Enzimática
Feminino
Glicoproteínas/imunologia
Humanos
Infecção/sangue
Infecção/diagnóstico
Lúpus Eritematoso Sistêmico/sangue
Lúpus Eritematoso Sistêmico/diagnóstico
Masculino
Meia-Idade
beta 2-Glicoproteína I
title_short Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
title_full Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
title_fullStr Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
title_full_unstemmed Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
title_sort Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome.
author Santiago, Mittermayer Barreto
author_facet Santiago, Mittermayer Barreto
Martinelli, Reinaldo
Reis, Mitermayer Galvão dos
Reis, Eliana Almeida Gomes
Ko, Albert Icksang
Fontes, Roberto Dias
Silva, Moacir Paranhos
Nascimento, Eliane Góes
Jesus, Rogério de
Pierangeli, Silvia
Espinola, Ricardo
Gharavi, Azzudin
author_role author
author2 Martinelli, Reinaldo
Reis, Mitermayer Galvão dos
Reis, Eliana Almeida Gomes
Ko, Albert Icksang
Fontes, Roberto Dias
Silva, Moacir Paranhos
Nascimento, Eliane Góes
Jesus, Rogério de
Pierangeli, Silvia
Espinola, Ricardo
Gharavi, Azzudin
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santiago, Mittermayer Barreto
Martinelli, Reinaldo
Reis, Mitermayer Galvão dos
Reis, Eliana Almeida Gomes
Ko, Albert Icksang
Fontes, Roberto Dias
Silva, Moacir Paranhos
Nascimento, Eliane Góes
Jesus, Rogério de
Pierangeli, Silvia
Espinola, Ricardo
Gharavi, Azzudin
dc.subject.en.pt_BR.fl_str_mv Anticardiolipin
Antiphospholipid
Diagnostic test
Systemic lupus erythematosus
Anticorpos Anticardiolipina/imunologia
Síndrome Antifosfolipídica/sangue
topic Anticardiolipin
Antiphospholipid
Diagnostic test
Systemic lupus erythematosus
Anticorpos Anticardiolipina/imunologia
Síndrome Antifosfolipídica/sangue
Anticorpos Anticardiolipina/sangue
Síndrome Antifosfolipídica/diagnóstico
Glicoproteínas/sangue
Adulto
Síndrome Antifosfolipídica/imunologia
Ensaio de Imunoadsorção Enzimática
Feminino
Glicoproteínas/imunologia
Humanos
Infecção/sangue
Infecção/diagnóstico
Lúpus Eritematoso Sistêmico/sangue
Lúpus Eritematoso Sistêmico/diagnóstico
Masculino
Meia-Idade
beta 2-Glicoproteína I
dc.subject.decs.pt_BR.fl_str_mv Anticorpos Anticardiolipina/sangue
Síndrome Antifosfolipídica/diagnóstico
Glicoproteínas/sangue
Adulto
Síndrome Antifosfolipídica/imunologia
Ensaio de Imunoadsorção Enzimática
Feminino
Glicoproteínas/imunologia
Humanos
Infecção/sangue
Infecção/diagnóstico
Lúpus Eritematoso Sistêmico/sangue
Lúpus Eritematoso Sistêmico/diagnóstico
Masculino
Meia-Idade
beta 2-Glicoproteína I
description Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Núcleo de Reumatologia do Serviço de Clínica Médica. Salvador, BA, Brasil
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2014-04-30T14:02:18Z
dc.date.available.fl_str_mv 2014-04-30T14:02:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTIAGO, M. B. et al. Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome. Clinical Rheumatology, v. 23, n. 6, p. 485-489, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7558
dc.identifier.issn.none.fl_str_mv 0770-3198
dc.identifier.doi.none.fl_str_mv 10.1007/s10067-004-0924-5
identifier_str_mv SANTIAGO, M. B. et al. Diagnostic performance of anti-beta2 glycoprotein I and anticardiolipin assays for clinical manifestations of the antiphospholipid syndrome. Clinical Rheumatology, v. 23, n. 6, p. 485-489, 2004.
0770-3198
10.1007/s10067-004-0924-5
url https://www.arca.fiocruz.br/handle/icict/7558
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Clinical Rheumatology
publisher.none.fl_str_mv Clinical Rheumatology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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