Detalhes bibliográficos
| Autor(a) principal: |
Vilela, Márcia Carvalho |
| Data de Publicação: |
2011 |
| Outros Autores: |
Campos, Roberta Dayrell de Lima,
Mansur, Daniel Santos,
Rodrigues, David Henrique,
Queiroz, Norinne Lacerda,
Lima, Graciela Kunrath,
Rachid, Milene Alvarenga,
Kroon, Erna Geessien,
Campos, Marco Antônio,
Teixeira, Antônio Lúcio |
| Tipo de documento: |
Artigo
|
| Idioma: |
eng |
| Título da fonte: |
Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: |
https://www.arca.fiocruz.br/handle/icict/9371
|
Resumo: |
Herpes simplex virus-1 (HSV-1) is a pathogen that may cause severe encephalitis in humans. In this study, we aimed to investigate the role of interleukin-4 (IL-4) in a model of HSV-1 brain infection. IL-4 knockout (IL-4-/-) and wild type (WT) C57BL/6 mice were inoculated with 104 plaque-forming units of HSV-1 by the intracranial route. Histopathologic analysis revealed a distinct profile of infiltrating cells at 3 days post-infection (dpi). Infected WT mice presented mononuclear inflammatory cells while IL-4-/- mice developed meningoencephalitis with predominance of neutrophils. IL-4-/- mice had diminished leukocyte adhesion at 3 dpi when compared to infected WT animals in intravital microscopy study. Conversely no differences were found in cerebral levels of CXCL1, CXCL9, CCL3, CCL5 and TNF-α between WT and IL-4-/- infected mice. IL-4 may play a role in the recruitment of cells into central nervous system in this acute model of severe encephalitis caused by HSV-1. |