Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.

Bibliographic Details
Main Author: Cotrim, Helma Pinchemel
Publication Date: 2009
Other Authors: Freitas, Luiz Antonio Rodrigues de, Alves, Erivaldo, Almeida, Alessandro de Moura, May, Daniel Simões, Caldwell, Stephen H.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/7812
Summary: Universidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, Brasil
id CRUZ_74f7c96770fc2d6a6d92240c8702ed4c
oai_identifier_str oai:www.arca.fiocruz.br:icict/7812
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Cotrim, Helma PinchemelFreitas, Luiz Antonio Rodrigues deAlves, ErivaldoAlmeida, Alessandro de MouraMay, Daniel SimõesCaldwell, Stephen H.2014-06-11T16:42:30Z2014-06-11T16:42:30Z2009COTRIM, H. P. et al. Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients. European Journal of Gastroenterology & Hepatology, v. 21, n. 9, p. 969-972, 2009.1473-568710.1097/MEG.0b013e328328f3echttps://www.arca.fiocruz.br/handle/icict/7812engLippincott Williams & WilkinsEffects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilCenter for the Surgical Treatment of Obesity. Salvador, BA, BrasilUniversidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, BrasilUniversidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, BrasilDivision of GI/Hepatology. University of Virginia. Charlottesville, USAOBJECTIVES: The effect of light-to-moderate alcohol consumption (LMAC) in nonalcoholic fatty liver disease (NAFLD) remains a controversial subject. The aim of this study was to evaluate the relationship between LMAC and the severity of NAFLD in morbidly obese patients. METHODS: We studied 132 patients undergoing liver biopsy during bariatric surgery. The patients were divided into three groups: G1: alcohol intake greater than 20 g/day and less than 40 g/day; G2: alcohol intake less than 20 g/day; G3: no alcohol intake. Insulin resistance was defined by the Homeostasis Model Assessment (>3). NAFLD was classified according to the Matteoni types: type I: steatosis alone; type II: steatosis with inflammation; types III-IV: steatosis with ballooning and/or fibrosis. RESULTS: The mean age was 37.3+/-11 years. Sixty-three percent were females and body mass index was 43.9+/-5.6 kg/m. G1, G2, and G3 included 19, 56, and 57 patients, respectively. Histological diagnoses classified by levels of alcohol were: G1: 10.5% normal liver, 89.5% type III or IV; G2: 10.7% normal liver, 1.8% type I or II, and 87.5% grade III or IV; G3: 10.5% normal liver, 3.5% type I or II, and 86% type III or IV (one had cirrhosis). The presence of IR was similar in moderate and no alcohol consumption (81.3 and 78.7%) but significantly less in the light consumption group (54%, P<0.05). CONCLUSION: The results suggest that LMAC may have a protection effect against IR in severely obese patients. However, it had no impact on the severity of activity and stage of liver disease.Alcoholic liver diseaseInsulin resistanceNonalcoholic fatty liver diseaseObesityConsumo de Bebidas Alcoólicas/efeitos adversosFígado Gorduroso/patologiaObesidade Mórbida/complicaçõesAdultoIdosoCirurgia BariátricaÍndice de Massa CorporalEstudos TransversaisFígado Gorduroso/quimioterapiaFemininoHumanosResistência à Insulina/fisiologiaMasculinoMeia-IdadeObesidade Mórbida/quimioterapiaAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCotrim HP Effects of light-to....pdfCotrim HP Effects of light-to....pdfapplication/pdf87293https://www.arca.fiocruz.br/bitstream/icict/7812/1/Cotrim%20HP%20Effects%20of%20light-to....pdff939fbfab25416e2ba3f949679789879MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7812/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCotrim HP Effects of light-to....pdf.txtCotrim HP Effects of light-to....pdf.txtExtracted texttext/plain21833https://www.arca.fiocruz.br/bitstream/icict/7812/5/Cotrim%20HP%20Effects%20of%20light-to....pdf.txt565cd78bb1d15aee2eef00cbe529c98bMD55THUMBNAILCotrim HP Effects of light-to....pdf.jpgCotrim HP Effects of light-to....pdf.jpgGenerated Thumbnailimage/jpeg2754https://www.arca.fiocruz.br/bitstream/icict/7812/4/Cotrim%20HP%20Effects%20of%20light-to....pdf.jpgf09de31b3734ef0d7615e7ed5c315f48MD54icict/78122023-03-15 14:33:23.05oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
title Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
spellingShingle Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
Cotrim, Helma Pinchemel
Alcoholic liver disease
Insulin resistance
Nonalcoholic fatty liver disease
Obesity
Consumo de Bebidas Alcoólicas/efeitos adversos
Fígado Gorduroso/patologia
Obesidade Mórbida/complicações
Adulto
Idoso
Cirurgia Bariátrica
Índice de Massa Corporal
Estudos Transversais
Fígado Gorduroso/quimioterapia
Feminino
Humanos
Resistência à Insulina/fisiologia
Masculino
Meia-Idade
Obesidade Mórbida/quimioterapia
Adulto Jovem
title_short Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
title_full Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
title_fullStr Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
title_full_unstemmed Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
title_sort Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
author Cotrim, Helma Pinchemel
author_facet Cotrim, Helma Pinchemel
Freitas, Luiz Antonio Rodrigues de
Alves, Erivaldo
Almeida, Alessandro de Moura
May, Daniel Simões
Caldwell, Stephen H.
author_role author
author2 Freitas, Luiz Antonio Rodrigues de
Alves, Erivaldo
Almeida, Alessandro de Moura
May, Daniel Simões
Caldwell, Stephen H.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cotrim, Helma Pinchemel
Freitas, Luiz Antonio Rodrigues de
Alves, Erivaldo
Almeida, Alessandro de Moura
May, Daniel Simões
Caldwell, Stephen H.
dc.subject.en.pt_BR.fl_str_mv Alcoholic liver disease
Insulin resistance
Nonalcoholic fatty liver disease
Obesity
topic Alcoholic liver disease
Insulin resistance
Nonalcoholic fatty liver disease
Obesity
Consumo de Bebidas Alcoólicas/efeitos adversos
Fígado Gorduroso/patologia
Obesidade Mórbida/complicações
Adulto
Idoso
Cirurgia Bariátrica
Índice de Massa Corporal
Estudos Transversais
Fígado Gorduroso/quimioterapia
Feminino
Humanos
Resistência à Insulina/fisiologia
Masculino
Meia-Idade
Obesidade Mórbida/quimioterapia
Adulto Jovem
dc.subject.decs.pt_BR.fl_str_mv Consumo de Bebidas Alcoólicas/efeitos adversos
Fígado Gorduroso/patologia
Obesidade Mórbida/complicações
Adulto
Idoso
Cirurgia Bariátrica
Índice de Massa Corporal
Estudos Transversais
Fígado Gorduroso/quimioterapia
Feminino
Humanos
Resistência à Insulina/fisiologia
Masculino
Meia-Idade
Obesidade Mórbida/quimioterapia
Adulto Jovem
description Universidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2014-06-11T16:42:30Z
dc.date.available.fl_str_mv 2014-06-11T16:42:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COTRIM, H. P. et al. Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients. European Journal of Gastroenterology & Hepatology, v. 21, n. 9, p. 969-972, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7812
dc.identifier.issn.none.fl_str_mv 1473-5687
10.1097/MEG.0b013e328328f3ec
identifier_str_mv COTRIM, H. P. et al. Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients. European Journal of Gastroenterology & Hepatology, v. 21, n. 9, p. 969-972, 2009.
1473-5687
10.1097/MEG.0b013e328328f3ec
url https://www.arca.fiocruz.br/handle/icict/7812
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7812/1/Cotrim%20HP%20Effects%20of%20light-to....pdf
https://www.arca.fiocruz.br/bitstream/icict/7812/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/7812/5/Cotrim%20HP%20Effects%20of%20light-to....pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/7812/4/Cotrim%20HP%20Effects%20of%20light-to....pdf.jpg
bitstream.checksum.fl_str_mv f939fbfab25416e2ba3f949679789879
7d48279ffeed55da8dfe2f8e81f3b81f
565cd78bb1d15aee2eef00cbe529c98b
f09de31b3734ef0d7615e7ed5c315f48
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324661719662592

Similar Items