Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55247 |
Resumo: | National Institutes of Allergy and Infectious Diseases |
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Sobral, LucianaArriaga, María B.Souza, Alexandra B.Pereira, Mariana AraújoDuarte, Beatriz BarretoSales, CaioRocha, Michael S.Benjamin, AlineMoreira, Adriana S. R.Oliveira, Jamile G. deCarvalho, Anna CristinaGomes, Renata SpenerFigueiredo, Marina C.Cavalcante, SolangeDurovni, BetinaSilva, José R. Lapa eKritski, Afrânio L.Rolla, Valeria C.Sterling, Timothy R.Santos, Marcelo CordeiroAndrade, Bruno B.2022-10-23T19:36:10Z2022-10-23T19:36:10Z2022SOBRAL, Luciana et al. Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study. The Lancet, v. 15, p. 1-13, Nov. 2022.0140-6736https://www.arca.fiocruz.br/handle/icict/5524710.1016/j. lana.2022.1003581474-547XNational Institutes of Allergy and Infectious DiseasesCentro Universitário Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Perú.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Boca do Acre, AM, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Atenção à Saúde São Francisco de Assis. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Atenção à Saúde São Francisco de Assis. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil.Prefeitura da Cidade do Rio de Janeiro. Secretaria Municipal de Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Atenção à Saúde São Francisco de Assis. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Boca do Acre, AM, Brasil / Universidade do Estado do Amazonas. Boca do Acre, AM, Brasil.Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases Nashville, TN, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Prefeitura da Cidade do Rio de Janeiro. Secretaria Municipal de Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Atenção à Saúde São Francisco de Assis. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil / Prefeitura da Cidade do Rio de Janeiro. Secretaria Municipal de Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Atenção à Saúde São Francisco de Assis. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Atenção à Saúde São Francisco de Assis. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases Nashville, TN, USA.Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Boca do Acre, AM, Brasil / Universidade Nilton Lins. Manaus, AM, Brasil.Centro Universitário Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases Nashville, TN, USA.Background: Approximately 10% of the global tuberculosis (TB) burden is in children. Identification, diagnosis, and early treatment of Mycobacterium tuberculosis infection (TBI) is critical to prevent progression to TB in children. The risk of TB, including severe disease, is highest in children <5 years old. We evaluated the cascade of TBI care among child and adolescent TB contacts to identify factors associated with losses in the cascade. Methods: Close contacts ≤ 18 years old of pulmonary TB patients enrolled between 2015 and 2019 in a multi-centre Brazilian cohort were followed for up to 24 months and classified according to age groups: <5 years, 5−9 years, 10−14 years and 15−18 years. Data on clinical investigation, radiographic examination, IGRA testing at baseline and 6 months, initiation and completion of TB preventive treatment (TPT) were collected. Multivariable regression analyses identified factors associated with TBI and losses in the cascade of care in children and adolescents. Findings: Among 1795 TB contacts initially identified, 530 (29·5%) were ≤18 years old. Losses for all steps in the cascade were especially high in children <5 years old (88%) because at this age all contacts are recommended to initiate TPT. As a proportion of all children, completion of TPT was low (between 10% and 13%) in all age-groups. Furthermore, multivariable regression revealed that younger age of contacts and TB index cases who were female, had pulmonary cavities, and persistent cough were independently associated with losses in the cascade of care among persons ≤18 years old. Interpretation: Losses in the TBI cascade were the highest among children <5 years, which was the group at highest risk for TB among the four age groups. The findings highlight the need to improve screening, initiation, and completion of TPT of young children who are close contacts of people with TB in Brazil.engElsevierDeterminants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLatent tuberculosisContactPediatricTBI cascadeChildreninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.en_US.fl_str_mv |
Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study |
| title |
Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study |
| spellingShingle |
Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study Sobral, Luciana Latent tuberculosis Contact Pediatric TBI cascade Children |
| title_short |
Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study |
| title_full |
Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study |
| title_fullStr |
Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study |
| title_full_unstemmed |
Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study |
| title_sort |
Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study |
| author |
Sobral, Luciana |
| author_facet |
Sobral, Luciana Arriaga, María B. Souza, Alexandra B. Pereira, Mariana Araújo Duarte, Beatriz Barreto Sales, Caio Rocha, Michael S. Benjamin, Aline Moreira, Adriana S. R. Oliveira, Jamile G. de Carvalho, Anna Cristina Gomes, Renata Spener Figueiredo, Marina C. Cavalcante, Solange Durovni, Betina Silva, José R. Lapa e Kritski, Afrânio L. Rolla, Valeria C. Sterling, Timothy R. Santos, Marcelo Cordeiro Andrade, Bruno B. |
| author_role |
author |
| author2 |
Arriaga, María B. Souza, Alexandra B. Pereira, Mariana Araújo Duarte, Beatriz Barreto Sales, Caio Rocha, Michael S. Benjamin, Aline Moreira, Adriana S. R. Oliveira, Jamile G. de Carvalho, Anna Cristina Gomes, Renata Spener Figueiredo, Marina C. Cavalcante, Solange Durovni, Betina Silva, José R. Lapa e Kritski, Afrânio L. Rolla, Valeria C. Sterling, Timothy R. Santos, Marcelo Cordeiro Andrade, Bruno B. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sobral, Luciana Arriaga, María B. Souza, Alexandra B. Pereira, Mariana Araújo Duarte, Beatriz Barreto Sales, Caio Rocha, Michael S. Benjamin, Aline Moreira, Adriana S. R. Oliveira, Jamile G. de Carvalho, Anna Cristina Gomes, Renata Spener Figueiredo, Marina C. Cavalcante, Solange Durovni, Betina Silva, José R. Lapa e Kritski, Afrânio L. Rolla, Valeria C. Sterling, Timothy R. Santos, Marcelo Cordeiro Andrade, Bruno B. |
| dc.subject.en.en_US.fl_str_mv |
Latent tuberculosis Contact Pediatric TBI cascade |
| topic |
Latent tuberculosis Contact Pediatric TBI cascade Children |
| dc.subject.en.none.fl_str_mv |
Children |
| description |
National Institutes of Allergy and Infectious Diseases |
| publishDate |
2022 |
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2022-10-23T19:36:10Z |
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2022-10-23T19:36:10Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SOBRAL, Luciana et al. Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study. The Lancet, v. 15, p. 1-13, Nov. 2022. |
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https://www.arca.fiocruz.br/handle/icict/55247 |
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0140-6736 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j. lana.2022.100358 |
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1474-547X |
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SOBRAL, Luciana et al. Determinants of losses in the tuberculosis infection cascade of care among children and adolescent contacts of pulmonary tuberculosis cases: a brazilian multi-centre longitudinal study. The Lancet, v. 15, p. 1-13, Nov. 2022. 0140-6736 10.1016/j. lana.2022.100358 1474-547X |
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https://www.arca.fiocruz.br/handle/icict/55247 |
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eng |
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openAccess |
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Elsevier |
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Elsevier |
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