Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways

Detalhes bibliográficos
Autor(a) principal: Oliveira, Maria Talita Pacheco de
Data de Publicação: 2019
Outros Autores: Coutinho, Diego de Sá, Souza, Éverton Tenório de, Guterres, Sílvia Stanisçuaski, Pohlmann, Adriana Raffin, Silva, Patricia Machado Rodrigues, Martins, Marco Aurélio, Bernardi, Andressa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40939
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
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spelling Oliveira, Maria Talita Pacheco deCoutinho, Diego de SáSouza, Éverton Tenório deGuterres, Sílvia StanisçuaskiPohlmann, Adriana RaffinSilva, Patricia Machado RodriguesMartins, Marco AurélioBernardi, Andressa2020-04-23T17:48:02Z2020-04-23T17:48:02Z2019OLIVEIRA, Maria Talita Pacheco de et al. Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways. International Journal of Nanomedicine, v. 14, p. 5215-5228, 2019.1176-9114https://www.arca.fiocruz.br/handle/icict/4093910.2147/IJN.S2006661178-2013engDove Medical PressBiodistribuiçãoEntrega de drogasEfeito anti-inflamatórioPortadores de lipídios nanoestruturadosBiodistributionDrug deliveryAnti-inflammatory effectNanostructured lipid carriersOrally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathwaysinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós-Graduação em Ciências Farammacêuticas. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Instituto de Química. Departamento de Química Orgânica. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Background: Resveratrol (RSV) has attracted interest as an alternative drug for the treatment of acute lung injury (ALI) and other pulmonary diseases, but its poor oral bioavailability is a limitation. In this study, we employed drug delivery nanotechnology to improve the stability, lung localization and efficacy of orally administered resveratrol to control lung damage leading to ALI. Methods and materials: RSV-loaded lipid-core nanocapsules (RSV-LNCs), prepared by interfacial deposition of biodegradable polymers, were given orally to A/J mice prior to lipopolysaccharide (LPS) intranasal instillation. Inflammatory changes, oxidative stress and lung tissue elastance were assessed 24 h after LPS challenge. Results: RSV-LNCs (5 mg/kg), given 1, 4, 6 or 12 h but not 24 h before provocation, inhibited LPS-induced leukocyte accumulation in the bronchoalveolar fluid (BALF), whereas unloaded nanocapsules (ULNCs) or free RSV (5 mg/kg) were ineffective. RSV-LNCs (2.5–10 mg/kg) but not ULNCs or RSV improved lung function and prevented total leukocyte and neutrophil accumulation equally in both BALF and lung tissue when given 4 h before LPS challenge. Similar findings were seen concerning the generation of a range of pro-inflammatory cytokines such as IL-6, KC, MIP-1α, MIP-2, MCP-1 and RANTES in lung tissue. In addition, only RSV-LNCs inhibited MDA levels and SOD activity in parallel with blockade of the ERK and PI3K/Akt pathways following LPS provocation. Conclusion: Nanoformulation of RSV in biodegradable oil-core polymers is an effective strategy to improve the anti-ALI activity of RSV, suggesting that the modified-release formulation of this plant polyphenol may be of great value in clinical conditions associated with ALI and respiratory failure.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40939/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarcoAMArtins_PMRSilva_etal_IOC_2019.pdfMarcoAMArtins_PMRSilva_etal_IOC_2019.pdfapplication/pdf2656934https://www.arca.fiocruz.br/bitstream/icict/40939/2/MarcoAMArtins_PMRSilva_etal_IOC_2019.pdff7fd61a724e0c49c34f94bd3bb42108fMD52TEXTMarcoAMArtins_PMRSilva_etal_IOC_2019.pdf.txtMarcoAMArtins_PMRSilva_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
title Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
spellingShingle Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
Oliveira, Maria Talita Pacheco de
Biodistribuição
Entrega de drogas
Efeito anti-inflamatório
Portadores de lipídios nanoestruturados
Biodistribution
Drug delivery
Anti-inflammatory effect
Nanostructured lipid carriers
title_short Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
title_full Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
title_fullStr Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
title_full_unstemmed Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
title_sort Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways
author Oliveira, Maria Talita Pacheco de
author_facet Oliveira, Maria Talita Pacheco de
Coutinho, Diego de Sá
Souza, Éverton Tenório de
Guterres, Sílvia Stanisçuaski
Pohlmann, Adriana Raffin
Silva, Patricia Machado Rodrigues
Martins, Marco Aurélio
Bernardi, Andressa
author_role author
author2 Coutinho, Diego de Sá
Souza, Éverton Tenório de
Guterres, Sílvia Stanisçuaski
Pohlmann, Adriana Raffin
Silva, Patricia Machado Rodrigues
Martins, Marco Aurélio
Bernardi, Andressa
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Maria Talita Pacheco de
Coutinho, Diego de Sá
Souza, Éverton Tenório de
Guterres, Sílvia Stanisçuaski
Pohlmann, Adriana Raffin
Silva, Patricia Machado Rodrigues
Martins, Marco Aurélio
Bernardi, Andressa
dc.subject.other.pt_BR.fl_str_mv Biodistribuição
Entrega de drogas
Efeito anti-inflamatório
Portadores de lipídios nanoestruturados
topic Biodistribuição
Entrega de drogas
Efeito anti-inflamatório
Portadores de lipídios nanoestruturados
Biodistribution
Drug delivery
Anti-inflammatory effect
Nanostructured lipid carriers
dc.subject.en.pt_BR.fl_str_mv Biodistribution
Drug delivery
Anti-inflammatory effect
Nanostructured lipid carriers
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-04-23T17:48:02Z
dc.date.available.fl_str_mv 2020-04-23T17:48:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Maria Talita Pacheco de et al. Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways. International Journal of Nanomedicine, v. 14, p. 5215-5228, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40939
dc.identifier.issn.pt_BR.fl_str_mv 1176-9114
dc.identifier.doi.none.fl_str_mv 10.2147/IJN.S200666
dc.identifier.eissn.none.fl_str_mv 1178-2013
identifier_str_mv OLIVEIRA, Maria Talita Pacheco de et al. Orally delivered resveratrol-loaded lipid-core nanocapsules ameliorate LPS-induced acute lung injury via the ERK and PI3K/Akt pathways. International Journal of Nanomedicine, v. 14, p. 5215-5228, 2019.
1176-9114
10.2147/IJN.S200666
1178-2013
url https://www.arca.fiocruz.br/handle/icict/40939
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40939/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/40939/2/MarcoAMArtins_PMRSilva_etal_IOC_2019.pdf
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