Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon

Souza, Hugo Amorim dos Santos de; Escafa, Victor Fernandes; Blanco, Carolina Moreira; Baptista, Carolina Moreira; Barros, Jenifer Peixoto; Riccio, Evelyn Ketty Pratt; Rodrigues, Aline Beatriz Mello; Melo, Gisely Cardoso de; Lacerda, Marcus Vinícius Guimarães de; Souza, Rodrigo Medeiros de; Lima Junior, Josué da Costa; Guimarães, Ana Carolina Ramos; Mota, Fabio Faria da; Silva, João Hermínio Martins da; Ribeiro, Cláudio Tadeu Daniel; Pratt-Riccio, Lilian Rose; Totino, Paulo Renato Rivas

Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal:	Souza, Hugo Amorim dos Santos de
Data de Publicação:	2021
Outros Autores:	Escafa, Victor Fernandes, Blanco, Carolina Moreira, Baptista, Carolina Moreira, Barros, Jenifer Peixoto, Riccio, Evelyn Ketty Pratt, Rodrigues, Aline Beatriz Mello, Melo, Gisely Cardoso de, Lacerda, Marcus Vinícius Guimarães de, Souza, Rodrigo Medeiros de, Lima Junior, Josué da Costa, Guimarães, Ana Carolina Ramos, Mota, Fabio Faria da, Silva, João Hermínio Martins da, Ribeiro, Cláudio Tadeu Daniel, Pratt-Riccio, Lilian Rose, Totino, Paulo Renato Rivas
Tipo de documento:	Artigo
Idioma:	por
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/47887
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Souza, Hugo Amorim dos Santos deEscafa, Victor FernandesBlanco, Carolina MoreiraBaptista, Carolina MoreiraBarros, Jenifer PeixotoRiccio, Evelyn Ketty PrattRodrigues, Aline Beatriz MelloMelo, Gisely Cardoso deLacerda, Marcus Vinícius Guimarães deSouza, Rodrigo Medeiros deLima Junior, Josué da CostaGuimarães, Ana Carolina RamosMota, Fabio Faria daSilva, João Hermínio Martins daRibeiro, Cláudio Tadeu DanielPratt-Riccio, Lilian RoseTotino, Paulo Renato Rivas2021-06-27T18:30:17Z2021-06-27T18:30:17Z2021SOUZA, Hugo Amorim dos Santos de et al. Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e200584, 6 p, May 2021.0074-0276https://www.arca.fiocruz.br/handle/icict/4788710.1590/0074-027602005841678-8060porFundação Oswaldo Cruz. Instituto Oswaldo Cruz.P. vivaxDiversidade genéticaPlasmodium vivax metacaspase 1Plasmodium vivax metacaspase 1MetacaspaseGenetic diversityP. vivaxPlasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz.. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, Laboratório de Genômica Funcional e Bioinformática, Rio de Janeiro, RJ, Brasil.Universidade do Estado do Amazonas. Manaus, AM, Brasil / Fundação de Medicina Tropical Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil.Fundação de Medicina Tropical Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas and Maria Deane. Manaus, AM, Brasil.Universidade Federal do Acre. Centro de Pesquisa em Doenças Infecciosas. Centro Multidisciplinar. Rio Branco, AC, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Eusébio, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.In the present study, we investigated the genetic diversity of Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain in two municipalities of the main malaria hotspot in Brazil, i.e., the Juruá Valley, and observed complete sequence identity among all P. vivax field isolates and the Sal-1 reference strain. Analysis of PvMCA1 catalytic domain in different P. vivax genomic sequences publicly available also revealed a high degree of conservation worldwide, with very few amino acid substitutions that were not related to putative histidine and cysteine catalytic residues, whose involvement with the active site of protease was herein predicted by molecular modeling. The genetic conservation presented by PvMCA1 may contribute to its eligibility as a druggable target candidate in vivax malaria.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47887/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHugoASouza_PauloRTotino_etal_IOC_2021.pdfHugoASouza_PauloRTotino_etal_IOC_2021.pdfapplication/pdf2106676https://www.arca.fiocruz.br/bitstream/icict/47887/2/HugoASouza_PauloRTotino_etal_IOC_2021.pdf4cb749afd58c69d3df633f7f38f57138MD52TEXTHugoASouza_PauloRTotino_etal_IOC_2021.pdf.txtHugoASouza_PauloRTotino_etal_IOC_2021.pdf.txtExtracted texttext/plain28006https://www.arca.fiocruz.br/bitstream/icict/47887/3/HugoASouza_PauloRTotino_etal_IOC_2021.pdf.txt615ae3319d59c15aa1071d00d8a4cd6cMD53icict/478872022-06-24 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dc.title.pt_BR.fl_str_mv	Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
title	Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
spellingShingle	Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon Souza, Hugo Amorim dos Santos de P. vivax Diversidade genética Plasmodium vivax metacaspase 1 Plasmodium vivax metacaspase 1 Metacaspase Genetic diversity P. vivax
title_short	Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
title_full	Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
title_fullStr	Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
title_full_unstemmed	Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
title_sort	Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
author	Souza, Hugo Amorim dos Santos de
author_facet	Souza, Hugo Amorim dos Santos de Escafa, Victor Fernandes Blanco, Carolina Moreira Baptista, Carolina Moreira Barros, Jenifer Peixoto Riccio, Evelyn Ketty Pratt Rodrigues, Aline Beatriz Mello Melo, Gisely Cardoso de Lacerda, Marcus Vinícius Guimarães de Souza, Rodrigo Medeiros de Lima Junior, Josué da Costa Guimarães, Ana Carolina Ramos Mota, Fabio Faria da Silva, João Hermínio Martins da Ribeiro, Cláudio Tadeu Daniel Pratt-Riccio, Lilian Rose Totino, Paulo Renato Rivas
author_role	author
author2	Escafa, Victor Fernandes Blanco, Carolina Moreira Baptista, Carolina Moreira Barros, Jenifer Peixoto Riccio, Evelyn Ketty Pratt Rodrigues, Aline Beatriz Mello Melo, Gisely Cardoso de Lacerda, Marcus Vinícius Guimarães de Souza, Rodrigo Medeiros de Lima Junior, Josué da Costa Guimarães, Ana Carolina Ramos Mota, Fabio Faria da Silva, João Hermínio Martins da Ribeiro, Cláudio Tadeu Daniel Pratt-Riccio, Lilian Rose Totino, Paulo Renato Rivas
author2_role	author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Souza, Hugo Amorim dos Santos de Escafa, Victor Fernandes Blanco, Carolina Moreira Baptista, Carolina Moreira Barros, Jenifer Peixoto Riccio, Evelyn Ketty Pratt Rodrigues, Aline Beatriz Mello Melo, Gisely Cardoso de Lacerda, Marcus Vinícius Guimarães de Souza, Rodrigo Medeiros de Lima Junior, Josué da Costa Guimarães, Ana Carolina Ramos Mota, Fabio Faria da Silva, João Hermínio Martins da Ribeiro, Cláudio Tadeu Daniel Pratt-Riccio, Lilian Rose Totino, Paulo Renato Rivas
dc.subject.other.pt_BR.fl_str_mv	P. vivax Diversidade genética Plasmodium vivax metacaspase 1
topic	P. vivax Diversidade genética Plasmodium vivax metacaspase 1 Plasmodium vivax metacaspase 1 Metacaspase Genetic diversity P. vivax
dc.subject.en.pt_BR.fl_str_mv	Plasmodium vivax metacaspase 1 Metacaspase Genetic diversity P. vivax
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.
publishDate	2021
dc.date.accessioned.fl_str_mv	2021-06-27T18:30:17Z
dc.date.available.fl_str_mv	2021-06-27T18:30:17Z
dc.date.issued.fl_str_mv	2021
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	SOUZA, Hugo Amorim dos Santos de et al. Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e200584, 6 p, May 2021.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/47887
dc.identifier.issn.pt_BR.fl_str_mv	0074-0276
dc.identifier.doi.none.fl_str_mv	10.1590/0074-02760200584
dc.identifier.eissn.none.fl_str_mv	1678-8060
identifier_str_mv	SOUZA, Hugo Amorim dos Santos de et al. Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e200584, 6 p, May 2021. 0074-0276 10.1590/0074-02760200584 1678-8060
url	https://www.arca.fiocruz.br/handle/icict/47887
dc.language.iso.fl_str_mv	por
language	por
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/47887/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/47887/2/HugoASouza_PauloRTotino_etal_IOC_2021.pdf https://www.arca.fiocruz.br/bitstream/icict/47887/3/HugoASouza_PauloRTotino_etal_IOC_2021.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon

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